Life and Health - Transdisciplinary Research Area (TRA) University of Bonn
Life exists in complex structures, from the smallest molecules that interact with each other to the interplay of various organisms in ecological systems. Understanding the complexity of life is therefore one of the most fascinating research topics. If researchers decipher the mechanisms underlying life, this will provide the basis for a better understanding of diseases and the development of new therapies. In a lively research environment and together with the Cluster of Excellence "ImmunoSensation2", the Transdisciplinary Research Area "Life and Health" of the University of Bonn focuses on comprehending life - from the level of the tiniest particles to the interaction of complex systems with the environment. One of the main objectives is the development of new strategies to improve and maintain health.
Research Professorships of the Transdisciplinary Research Area
Hertz Chair for Artificial Intelligence and Neuroscience
Prof. Dr. Dr. Dominik Bach
Dominik Bach establishs a new focus at the interface between neuroscience, psychiatry and computer science in TRA Life and Health.
Argelander Professorship for Organoids and Chemical Biology
Jun.-Prof. Dr. Elena Reckzeh
Elena Reckzeh combines chemical biology with organoid research to further develop the area of 'Construction' in TRA Life and Health's research profile.
Argelander Professorship for Organoid Biology
Jun.-Prof. Dr. Ana Ivonne Vazquez-Armendariz
Ana Ivonne Vazquez-Armendariz adds a new area of focus to TRA Life and Health's research profile 'Construction & Deconstruction of Life' with her expertise on lung organoids.
Our members
Our members are professors and group leaders of the University of Bonn and cooperating Bonn institutions from medicine, life sciences, pharmacy, nutrition research, mathematics, computer science and other fields.
Become TRA member!
As TRA member, you will have access to TRA funding and opportunities for networking beyond the borders of your own discipline.
Bonn Organoid Day - June 18, 2024
With around 70 participants and more than 40 active contributions (short talks and flash talks), the first “Bonn Organoid Day” has been a big success! Scientists of all career levels with interest in organoid techniques discussed about a wide range of application fields for research questions in many different tissues/organs (tonsil, kidney, skin, bone, gut, lung, brain, retina, adipose tissue and more). The program also included presentations on more overarching topics such as ethical frontiers in organoid research, state-of-the-art microscopy techniques, mathematical modelling or services provided by the cell reprogramming core facility. The event ended with drinks and more discussions during a nice barbecue and after the thunderstorms had finally cleared away, we could even sit outside.
Please save the date for the Bonn Organoid Symposium: 6 November 2024.
Observing the brain in extreme situations
Hertz professor Dominik Bach and his team want to decipher how the brain works and analyze human behavior in extreme situations. For this purpose, test subjects are confronted with simulated external threats, such as a bear attack, with the help of VR goggles.
Circuits for Survival - Inaugural Symposium on September 26, 2022
To celebrate the inaugural lecture of the Hertz Chair for "Artificial Intelligence and Neuroscience", Prof. Dr. Dr. Dominik Bach, TRA Life and Health hosted a scientific symposium on 26.09.2022.
Interdisciplinary hands-on workshop “Machine Learning” March 19 + 20, 2024
Around 60 post-docs and doctoral students from the transdisciplinary research areas “Matter”, “Modelling”, “Life and Health” and the “Bonner Forum Biomedizin” (BFB) took part in this year's interdisciplinary hands-on workshop “Machine Learning”. At the two-day workshop, early career scientists gained insights into machine learning and its theoretical concepts. On the second day, presentations by Dr Maria Mircea, Dr Kim Nicoli and Dr Jens Tillmann provided insights into the application of machine learning in various research areas. The event concluded with a small networking session for mutual exchange about what the participants had learnt and their research.
Impression: Bonn Conference on Mathematical Life Sciences 2023
Bonn Conference on Mathematical Life Sciences - a huge success!
More than 200 scientists discussed at the four-day symposium of TRAs "Modelling" and "Life and Health" as well as Clusters of Excellence HCM and ImmunoSensation2 the current state of the research activities and potential future development in the field of mathematical modelling in the life sciences.
David Fußhöller (ImmunoSensation/UKB) presents a short video of the event.
Clubs
Mathematical Life Sciences (MaLiS) Club
The "MaLiS" Club meets regularly to discuss ongoing projects around mathematical questions in medicine and life sciences.
Next talk: Nov. 8, 2024
Bonn Organoid Club
The "Bonn Organoid Club" is a forum for interested researchers to exchange expertise and reagents on organoid models in biomedical research.
Next talk: Sep.10, 2024
Spatial Biology Club Bonn
The "Spatial Biology Club Bonn" aims to foster collaboration and knowledge-sharing among Bonn scientists engaged in or exploring spatial-omics.
Overview on talks and events
Bonner Forum Biomedizin provides an overview about talks, seminars, workshops with topics related to "Life and Health".
Would you like to announce an event? Please send an e-mail to talks@uni-bonn.de.
Contact
Dr. Meike Brömer
Whether or not a person becomes seriously ill with COVID-19 depends, among other things, on genetic factors. With this in mind, researchers from the University Hospital Bonn (UKB) and the University of Bonn, in cooperation with other research teams from Germany, the Netherlands, Spain and Italy, investigated a particularly large group of affected individuals. They confirmed the central and already known role of the TLR7 gene in severe courses of the disease in men, but were also able to find evidence for a contribution of the gene in women. In addition, they were able to show that genetic changes in three other genes of the innate immune system contribute to severe COVID-19. The results have now been published in the journal "Human Genetics and Genomics Advances".
The majority of rare diseases have a genetic cause. The underlying genetic alteration can be found more and more easily, for example by means of exome sequencing (ES), leading to a molecular genetic diagnosis. ES is an examination of all sections of our genetic material (DNA) that code for proteins. As part of a Germany-wide multicenter study, ES data was collected from 1,577 patients and systematically evaluated. This made it possible to diagnose a total of 499 patients, with 34 patients showing new, previously unknown genetic diseases. The study thus makes a significant contribution to the initial description of new diseases. In addition, software based on the use of artificial intelligence (AI) was used for the first time on a broad scale to support clinical diagnosis. The "GestaltMatcher" AI system can assist in the assessment of facial features with regard to the classification of congenital genetic syndromes. The results of the study, in which 16 universities and university hospitals were involved, including the University of Bonn, have now been published in the renowned journal "Nature Genetics".
New research by the University Hospital Bonn (UKB) in cooperation with the University of Bonn has shown for the first time that certain early changes in patients with age-related macular degeneration (AMD) can lead to a measurable local loss of vision. This discovery could help to improve the treatment and monitoring of this eye disease in older patients, which otherwise slowly leads to central blindness, and to test new therapies.
Researchers at the University of Bonn have isolated a DNA molecule that is suitable for combating allergic contact dermatitis in mice. What is known as an aptamer binds to certain immune system messenger substances, rendering them ineffective. This even works if the active ingredient is applied to the skin in the form of an ointment. The working groups involved hope that aptamer creams such as this could also be suitable for treating other skin conditions. The results have now been published in the journal Molecular Therapies - Nucleic Acids.