Research and Teaching at the University of Bonn

A receding hairline, a total loss of hair from the crown, and ultimately, the classical horseshoe-shaped pattern of baldness: Previous research into male pattern hair loss, also termed androgenetic alopecia, has implicated multiple common genetic variants. Human geneticists from the University Hospital of Bonn (UKB) and by the Transdisciplinary Research Unit "Life & Health" of the University of Bonn have now performed a systematic investigation of the extent to which rare genetic variants may also contribute to this disorder. For this purpose, they analyzed the genetic sequences of 72,469 male participants from the UK Biobank project. The analyses identified five significantly associated genes, and further corroborated genes implicated in previous research. The results have now been published in the prestigious scientific journal Nature Communications.

The mathematician Prof. Dr. Angkana Rüland from the Hausdorff Center for Mathematics (HCM) Cluster of Excellence at the University of Bonn is to be presented with the illustrious New Horizons Prize for her outstanding work on applied analysis. The high-caliber $100,000 award is conferred by the Breakthrough Prize Foundation. The 35-year-old researcher and University of Bonn alumna was only appointed to one of its prestigious Hausdorff Chairs at the start of the year. In her research, she draws inspiration from problems encountered in the natural sciences.

Every year some 75,000 people die from bacterial blood poisoning, or sepsis, in Germany alone. Survivors of sepsis often struggle with secondary and concomitant conditions due to the resulting impairment of the immune system, the so called “Immunesuppression”. The International Center for Clinical Research (ICRC) at St. Anne's University Hospital (FNUSA) Brno (Czech Republic) has founded the research consortium “BEATSep”. HORIZON EUROPA is funding it with around 6,9 million euros over the next five years. The project aims to study the cellular and molecular mechanisms causing the immune suppression in sepsis survivors. Prof. Dr. Bernardo S. Franklin, Institute for Innate Immunity of the University Hospital Bonn and member of the ImmunoSensation2 Cluster of Excellence of the University of Bonn, is involved in the project. He receives about 800,000 euros from the EU funding.

Farmers usually plant so-called cover crops after harvesting their main crop in the Fall. This prevents erosion of the soil and nutrient leaching. The roots of these crops also stabilize the structure of the soil. It had been assumed up to now that a mixture of different cover crops would result in particularly intensive rooting. However, a recent study carried out by the University of Bonn, University of Kassel and University of Göttingen found only limited evidence that this is the case. Instead, mixed cover crops grow thinner roots than when just one single type of cover crop is planted. This result was unexpected. It documents how little is currently understood about the interactions between plant roots. The study was published in the magazine “Plant and Soil.”