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Welcome to the DFG Research Unit 854



 Post-Genomic Strategies for New Antibiotic Drugs and Targets


FOR 854 Titelbild

Antibiotic activity testing  -  Cell wall biosynthesis blocked in a staphylococcal cell  -  Structure of the antibiotic hormaomycin  -  Genome of Pseudomonas fluorescens Pf5   (figure legend from left to right) 


News - University of Bonn (Pressemitteilung): Forscher entdecken neuartiges Antibiotikum



Our collaborative research unit is a consortium of 8 individual projects with the objective to investigate promising new antibiotic compounds, molecular mechanisms and targets using post-genome era strategies. Our aims are to 


  • identify new antibiotic compounds through genome mining and generate structural variants through engineering of biosynthetic pathways and mutasynthesis


  • study new natural compounds as to their molecular mechanisms of action


  • investigate in detail molecular targets as to new aspects of antibiotic mechanisms and innovative therapeutic strategies.



Prof. Dr. Hans-Georg Sahl
Institute of Medical Microbiology, Immunology and Parasitology (IMMIP)
Pharmaceutical Microbiology
Universität Bonn
Meckenheimer Allee 168
53115 Bonn
Tel: +49 (0)228 73 5272; Fax: +49 (0)228 73 5267