Research Profile: Top-Level Research

A receding hairline, a total loss of hair from the crown, and ultimately, the classical horseshoe-shaped pattern of baldness: Previous research into male pattern hair loss, also termed androgenetic alopecia, has implicated multiple common genetic variants. Human geneticists from the University Hospital of Bonn (UKB) and by the Transdisciplinary Research Unit "Life & Health" of the University of Bonn have now performed a systematic investigation of the extent to which rare genetic variants may also contribute to this disorder. For this purpose, they analyzed the genetic sequences of 72,469 male participants from the UK Biobank project. The analyses identified five significantly associated genes, and further corroborated genes implicated in previous research. The results have now been published in the prestigious scientific journal Nature Communications.

The mathematician Prof. Dr. Angkana Rüland from the Hausdorff Center for Mathematics (HCM) Cluster of Excellence at the University of Bonn is to be presented with the illustrious New Horizons Prize for her outstanding work on applied analysis. The high-caliber $100,000 award is conferred by the Breakthrough Prize Foundation. The 35-year-old researcher and University of Bonn alumna was only appointed to one of its prestigious Hausdorff Chairs at the start of the year. In her research, she draws inspiration from problems encountered in the natural sciences.

Every year some 75,000 people die from bacterial blood poisoning, or sepsis, in Germany alone. Survivors of sepsis often struggle with secondary and concomitant conditions due to the resulting impairment of the immune system, the so called “Immunesuppression”. The International Center for Clinical Research (ICRC) at St. Anne's University Hospital (FNUSA) Brno (Czech Republic) has founded the research consortium “BEATSep”. HORIZON EUROPA is funding it with around 6,9 million euros over the next five years. The project aims to study the cellular and molecular mechanisms causing the immune suppression in sepsis survivors. Prof. Dr. Bernardo S. Franklin, Institute for Innate Immunity of the University Hospital Bonn and member of the ImmunoSensation2 Cluster of Excellence of the University of Bonn, is involved in the project. He receives about 800,000 euros from the EU funding.

Farmers usually plant so-called cover crops after harvesting their main crop in the Fall. This prevents erosion of the soil and nutrient leaching. The roots of these crops also stabilize the structure of the soil. It had been assumed up to now that a mixture of different cover crops would result in particularly intensive rooting. However, a recent study carried out by the University of Bonn, University of Kassel and University of Göttingen found only limited evidence that this is the case. Instead, mixed cover crops grow thinner roots than when just one single type of cover crop is planted. This result was unexpected. It documents how little is currently understood about the interactions between plant roots. The study was published in the magazine “Plant and Soil.”

Projects that reduce deforestation often sell carbon credits - for instance, to consumers purchasing airline tickets. However, over 90 percent of these project credits do not actually offset greenhouse gas emissions. This is the conclusion of a study conducted by the Vrije Universiteit Amsterdam (Netherlands), the University of Bonn, the University of Cambridge (United Kingdom) and the European Forest Institute in Barcelona (Spain). It was carried out on an exemplary basis for 26 projects in six countries. The results have now been published in the renowned journal Science.

More and more bacterial pathogens are developing resistance. There is an increasing risk that common drugs will no longer be effective against infectious diseases. That is why scientists around the world are searching for new effective substances. Researchers from the University of Bonn, the German Center for Infection Research (DZIF), Utrecht University (Netherlands), Northeastern University in Boston (USA) and the company NovoBiotic Pharmaceuticals in Cambridge (USA) now have discovered and deciphered the mode of action of a new antibiotic. Clovibactin is derived from a soil bacterium. This antibiotic is highly effective at attacking the cell wall of bacteria, including many multi-resistant “superbugs.” The results have now been published in the renowned journal “Cell.” 

In the recently published Shanghai Academic Ranking of World Universities (ARWU), the University of Bonn has ranked as one of Germany’s top four universities and in the top ten EU-wide, taking 67th place in the list of the world’s leading universities. Bonn thus moved up nine slots since last year on the worldwide ranking list.

A novel catalysis scheme enables chemical reactions that were previously virtually impossible. The method developed at the University of Bonn is also environmentally friendly and does not require rare and precious metals. The researchers recorded the exact course of the catalysis in a kind of high-speed film. They did this using special lasers that can make processes visible that last only fractions of a billionth of a second. The results allow them to further optimize the catalyst. They have been published in the international edition of the renowned journal “Angewandte Chemie.”