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Tanja Schneider
© Tanja Schneider
Prof. Dr. Tanja Schneider

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Zugehörigkeiten
  • Medizinische Fakultät
  • Institut für Pharmazeutische Mikrobiologie
Forschungsschwerpunkte
  • Antibiotic Mechanisms and Resistance
  • Novel Antibiotics
  • Antibiotic Screening
The Schneider group studies the bacterial cell envelope as a target for (new) antibiotics. Much of our current research focuses on the elucidation of molecular mechanisms of action and resistance of (new) antibiotics and the identification & characterization of novel antibacterial targets. Pivotal to these efforts is to understand the biology beyond a given target as well as its integration into the cellular network. Current research interests: Mode of action studies on novel antibiotics (e.g. teixobactin, plectasin, lipopeptides) Antibiotic resistance mechanisms Identification of new antibiotic targets and screening Investigations on cell envelope biosynthesis in S. aureus, particularly peptidoglycan, wall teichoic acid and capsule biosynthesis Regulation of cell envelope biosynthesis and modification.
Ausgewählte Publikationen

1. Lewis K, Lee RE, Brötz-Oesterhelt H, Hiller S, Rodnina MV, Schneider T, Weingarth M, Wohlgemuth I. Sophisticated natural products as antibiotics. Nature. 2024. 632(8023):39-49.

2. Shukla R, Peoples AJ, Ludwig KC, Maity S, Derks MGN, De Benedetti S, Krueger AM, Vermeulen BJA, Harbig T, Lavore F, Kumar R, Honorato RV, Grein F, Nieselt K, Liu Y, Bonvin AMJJ, Baldus M, Kubitscheck U, Breukink E, Achorn C, Nitti A, Schwalen CJ, Spoering AL, Ling LL, Hughes D, Lelli M, Roos WH, Lewis K, Schneider T*, Weingarth M*. An antibiotic from an uncultured bacterium binds to an immutable target. Cell. 2023. 186(19):4059-4073.e27. * corresponding author

3. Schneider, T.; Kruse, T., Wimmer, R.; Wiedemann, I.; Sass, V., Pag, U.; Jansen, A.; Nielsen, A.K.; Mygind, P.H.; Raventós, D.S.; Neve, S.; Ravn, B.; Bonvin, A.M.J.J.; De Maria, L; Andersen, A.S.; Gammelgaard, L.K.; Sahl, H.-G.; Kristensen, H-H. Plectasin, a fungal defensin, targets the bacterial cell wall precursor lipid II. Science. 2010, 328,1168-1172. DOI: 10.1126/science.1185723

Tanja Schneider
© Tanja Schneider
Prof. Dr. Tanja Schneider

Webseite

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