Michael Famulok
Prof. Michael Famulok
  • Life and Medical Sciences Institute (LIMES)
  • Faculty of Mathematics and Natural Sciences
Research topics
  • DNA Nanotechnology
  • Aptamer research
  • Chemical biology
DNA nanotechnology seeks to create synthetic functional entities inspired by nature. Interlocked DNA structures like rotaxanes and catenanes are possible versatile building blocks for such DNA machines, as they equip construction units with moving parts to build functional DNA machines that can perform specific tasks. An important step in controlling functionality is the ability to switch between different states of the DNA nanostructure. To this end, we are developing molecular switching elements that trigger specifically controllable structural rearrangements by light irradiation, toehold-extended nucleotides, or aptamer-mediated ligand binding, thereby conferring defined and controllable functionality to the DNA machine.
Selected publications

Valero J, Pal N, Dhakal S, Walter NG, Famulok M. (2018) A bio-hybrid DNA rotor-stator nanoengine that moves along predefined tracks. Nat Nanotechnol. 13, 496-503. doi: 10.1038/s41565-018-0109-z.

Yu Z, Centola M, Valero J, Matthies M, Šulc P, Famulok M. (2021) A Self-Regulating DNA Rotaxane Linear Actuator Driven by Chemical Energy. J Am Chem Soc. 143: 13292-13298. doi: 10.1021/jacs.1c06226.

Centola M, Poppleton E, Centola M, Valero J, Šulc P, Famulok M. (2021) A rhythmically pulsing leaf-spring nanoengine that drives a passive follower. BioRxiv. doi: https://doi.org/10.1101/2021.12.22.473833.


Michael Famulok
Prof. Michael Famulok
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