Günter Mayer
Prof. Günter Mayer
  • Life and Medical Sciences Institute (LIMES)
  • Faculty of Mathematics and Natural Sciences
Research topics
  • Aptamers
  • Optogenetics
  • Targeted therapies
We address the following research questions: How can aptamer technology be used to understand biological phenomena? How can nucleic acids be exploited as drugs or drug targets to develop novel diagnostic and therapeutic applications? What are the underlying principles of nucleic acid evolution in the test tube and how can these be employed to generate novel compounds? To address these and other questions, we utilize in vitro selection procedures, in combination with chemical, biochemical, immunological, neurological and molecular cell biology techniques. Our overall goal is to develop molecular tools that alllow us to investigate biological systems with high precision. These tools also represent the foundation for implementing novel diagnostic and therapeutic strategies.
Selected publications

Pfeiffer F, Tolle F, Rosenthal M, Brändle G, Ewers J, Mayer G. (2018) Identification and characterization of nucleobase-modified aptamers by click-SELEX. Nat. Protocols. 13:1153-1180.

Pilsl S, Morgan C, Choukeife M, Möglich A, Mayer G. (2020) Optoribogenetic control of regulatory RNA molecules. Nat Commun. 11, 4825.

Weber AM, Kaiser J, Ziegler T, Pilsl S, Renzl C, Sixt L, Pietruschka G, Moniot S, Kakoti A, Juraschitz M, Schrottke S, Lledo Bryant L, Steegborn C, Bittl R, Mayer G, Möglich A. (2019) A blue light receptor that mediates RNA binding and translational regulation. Nat Chem Biol. 15, 1085–1092.

Günter Mayer
Prof. Günter Mayer
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