Dirk Menche
Prof. Dr. Dirk Menche
  • Kekulé-Institut für Organische Chemie und Biochemie
  • Faculty of Mathematics and Natural Sciences
Research topics
  • Total synthesis of complex natural products
  • Synthetic method development
  • Structure-activity relationships
The research interests of our group are centred around natural products chemistry, ranging from natural product isolation and structure elucidation to total synthesis, as well as structure-activity studies and novel synthetic methodologies. We are particularly interested in complex polyketides and in recent years we have assigned the full 3D architecture of several complex and often highly active representatives, developed tailored preparative procedures that enabled elaborate and often first total syntheses of the parent natural products as well as designed analogues thereof that retained potent biological profiles.
Selected publications

Göricke B, Bieber MF, Mohr KE, Menche D (2019) Stereochemical Determination of Tuscolid/Tuscorons and Total Synthesis of Tuscoron D and E: Insights into the Tuscolid/Tuscoron Rearrangement. Angew Chem Int Ed Engl 58(37):13019-13023.

Herkommer D, Thiede S, Wosniok PR, Dreisigacker S, Tian M, Debnar T, Irschik H, Menche D (2015) Stereochemical determination of the leupyrrins and total synthesis of leupyrrin A1. J Am Chem Soc 137(12):4086-9.

Essig S, Bretzke S, Müller R, Menche D (2012) Full stereochemical determination of ajudazols A and B by bioinformatics gene cluster analysis and total synthesis of ajudazol B by an asymmetric ortholithiation strategy. J Am Chem Soc 134(47):19362-5.

Dirk Menche
Prof. Dr. Dirk Menche
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