Jun.-Prof. Patrycja Kielb

Argelander Professorship for Biohybrid Research

Research professorship in the Transdicplinary Research Area „Building Blocks of Matter and fundamental Interactions (Matter)“ of the University of Bonn.

© Bialek/Uni Bonn

BioSpectroElectrochemistry of natural and artificial metaloproteins

Parycja Kielb and her team aim at exploring how nature performs complicated redox reactions constituting key processes in the environment and life, like biomass  degradation and or cellular respiration. At the heart of such processes  are often redox biocatalytic metalloproteins which present the main  inspiration for our mechanistic investigations. The research team wants to understand how they can harness and further engineer the unrivaled efficiency of such natural biological systems towards the development of artificial biohybrid systems applicable in bioelectronic devices.

Methodologically, they employ the combination of experimental techniques including advanced Raman spectroscopy, electrochemistry, and protein engineering. Specifically, surface-enhanced resonance Raman spectro-electrochemistry allows them to correlate the structural information of the molecule interfaced on electrodes with its redox functionality.

Avatar Kielb

Junior Prof. Dr. Patrycja Kielb

Argelander-Professorship for Biohybrid Research, CIPTC, TRA Matter. Photo Copyright: Volker Lannert/Uni Bonn


Patrycja Kielb studied Molecular Biophysics at Jagiellonian University, Krakow, Poland which she completed with a Master Degree in 2012. Before finishing her Master’s, she performed various reserach internships: (i) at the Insittute of Catalysis and Physical Chemistry of Interfaces, Polish Academy of Sciences, Krakow, Poland and (ii) at Institute of Chemistry and Biology in Lisbon, Portugal as an Erasmus Scholar. After these research experiences, she became passionate about exploring the mechanistic details of catalytic reactions in natural systems. She continued to investigate these topics as a PhD Scholar of Excellence Cluster of Unifying Concepts in Catalysis (UniCat) at TU Berlin under supervision of Prof. Dr. Inez Weidinger and Prof. Dr. Peter Hildebrandt (Biophysical Chemistry). In this time, she explored redox properties and structure-function relationship of various heme-containing bio- and molecular catalysts which she defended in 2017 with summa cum laude. After her PhD, she joined the group of Prof. Harry B. Gray (Bioinorganic Chemistry) as a postdoc where she investigated the role of protein matrix in supporting redox reactions in metalloprotiens on the example of Cu-containing enzyme. In 2020, she returned to Germany for her 2nd postdoc at University of Potsdam with JProf. D. Henrike Müller-Werkmeister (Physical Chemistry). Shortly after that, in 2021 she started her independent group at the University of Bonn.


  • Electron transfer via coupled Tyr/Trp networks in metalloenzymes
  • Unraveling the molecular mechanism of O2-converting copper-containing enzymes
  • Rational design of artificial copper/heme-containing biocatalysts
  • UV/Vis Raman spectro-electrochemistry – method development



  • Advanced Physical Chemistry (obligatory module for MSc Chemistry)
  • Biophysical Chemistry (elective module for MSc Chemistry)

2021: Argelander Professorship for BioSpectroElectrochemistry, University of Bonn
2020 - 202: Postdoc, University of Potsdam, Group of H. Müller-Werkmeister 
2017 - 2019: Postdoc, California Institute of Technology, Pasadena, USA, Group of Harry Gray and Jay Winkler
2013 - 2017: PhD in Biophysical Chemistry, Technical University  Berlin, Group of Inez Weidinger and Peter Hildebrandt
2007 - 2012: M. Sc. in Biophysics (integrated with Bachelor Degree), Jagiellonian University, Krakow, Poland

Third-Party Funded Projects

DAAD Collaborative grant with France PROCOPE



DFG Major Research Instrumentation Grant for Raman Spectrometer



Global Cooperation Network Grant between University of St. Andrews and University of Bonn



Postdoc Bridge Fellowship, University of Potsdam


02/2020 – 07/2020


Best Poster Presentation Award



Awarded at:

16th European Conference on the Spectroscopy of Biological Molecules, Bochum, Germany


Does tyrosine protect S. coelicolor laccase from oxidative degradation or act as an extended catalytic site?

Kielb*, Teutloff, Bittl, Gray*, Winkler*

J. Phys. Chem. B. 126, 7943-7949 (2022).

Switchable redox chemistry of hexameric Tyrosine-coordinated heme protein.

Kielb, Utesch, Kozuch, Jeoung, Dobbek, Mroginski, Hildebrandt, Weidinger*

J. Phys. Chem. B. 121:3955-3964 (2017).

Spectroscopic observation of calcium-induced reorientation of cellobiose dehydrogenase immobilized on electrodes and ist effect on electrocatalytic activity.

Kielb, Sezer, Katz, Lopez, Schulz, Gorton, Ludwig, Wollenberger, Zebger, Weidinger*

ChemPhysChem 16(9):1960-1968 (2015).

Further information

Clausius Professorship

You  may also be interested in reading about the Clausius Professorship for Computational Quantum Field Theory.

TRA Matter

Understanding the formation of complex structures based on the fundamental building blocks of matter and their interactions.

Research profile

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