Thomas Becker
Prof. Dr. Thomas Becker
  • Institut für Biochemie und Molekularbiologie
Research topics
  • protein transport
  • mitochondria
Mitochondria import more than 99% of their proteins that are produced as precursors on cytosolic ribosomes. The translocase of the outer membrane (TOM complex) forms the entry gate for almost all mitochondrial precurcor proteins. Subsequently, dedicated protein translocases sort the proteins into the mitochondrial subcompartment. We investigate control that monitor and adapt protein transport into mitochondria to meet cellular requirements.
Selected publications

Mårtensson CU, Priesnitz C, Song J, Ellenrieder L, Doan KN, Boos F, Floerchinger A, Zufall N, Oeljeklaus S, Warscheid B, Becker T (2019) Mitochondrial protein translocation-associated degradation. Nature 569:679-683.

Ellenrieder L, Dieterle MP, Doan KN, Mårtensson CU, Floerchinger A, Campo ML, Pfanner N, Becker T (2019) Dual role of mitochondrial porin in metabolite transport across the outer membrane and protein transfer to inner membrane. Mol Cell 73: 1056-1057.

Ellenrieder L, Opalinski L, Becker L, Krüger V, Mirus O, Straub SP, Ebell K, Flinner N, Stiller SB, Guiard B, Meisinger C, Wiedemann N, Schleiff E, Wagner R, Pfanner N, Becker T (2016) Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10. Nat Commun 7:13021.

Qiu J, Wenz, LS, Zerbes RM, Oeljeklaus S, Bohnert M, Stroud DA, Wirth C, Ellenrieder L, Thornton N, Kutik S, Wiese S, Schulze-Specking A, Zufall N, Chacinska A, Guiard B, Hunte C, Warscheid B, van der Laan M, Pfanner N, Wiedemann N, Becker T (2013) Coupling of mitochondrial import and export translocases by receptor-mediated supercomplex formation. Cell 154:596-608.

Thomas Becker
Prof. Dr. Thomas Becker
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