Stefanie Kürten
Prof. Dr. Stefanie Kürten
  • Anatomisches Institut/Neuroanatomie
Research topics
  • Multiple Sclerosis
  • B-cells
  • biomarkers
Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system (CNS) and the most frequent neurological disease in young adults, leading to irreversible clinical deficits and premature retirement. On the one hand, my group focuses on the contribution of B cells and autoantibodies to the immunopathology of MS. Next to understanding the mechanisms of B cell-driven disease, we aim to develop novel therapeutic options and biomarkers for patients with MS. On the other hand, we are concerned with developing strategies to promote neuroregeneration and remyelination in the CNS.
Selected publications

Tacke S, Braune S, Rovituso DM, Ziemssen T, Lehmann PV, Dikow H, Bergmann A, Kuerten S (2021) B-cell activity predicts response to glatiramer acetate and interferon in relapsing-remitting MS. Neurol Neuroimmunol Neuroinflamm

Kuerten S, Lanz TV, Lingampalli N, Lahey LJ, Kleinschnitz C, Mäurer M, Schroeter M, Braune S, Ziemssen T, Ho PP, Robinson WH, Steinman L (2020) Autoantibodies against CNS antigens in a subset of B cell-dominant multiple sclerosis patients. Proc Natl Acad Sci U S A 117(35):21512-21518

Wunsch M, Jabari S, Voussen B, Enders M, Srinivasan S, Cossais F, Wedel T, Boettner M, Schwarz A, Weyer L, Göcer O, Schroeter M, Maeurer M, Woenckhaus M, Pollok K, Radbruch H, Klotz L, Scholz C, Nickel J, Friebe A, Addicks K, Ergün S, Lehmann PV, Kuerten S (2017) The enteric nervous system is a potential autoimmune target in multiple sclerosis. Acta Neuropathol 134(2):281-295

Schampel A, Volovitch O, Koeniger T, Scholz C, Jörg S, Linker RA, Wischmeyer E, Wunsch M, Hell JW, Ergün S, Kuerten S (2017) Nimodipine fosters remyelination in a mouse model of multiple sclerosis and induces microglia-specific apoptosis. Proc Natl Acad Sci U S A, 114(16):E3295-E3304

Stefanie Kürten
Prof. Dr. Stefanie Kürten
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