Stefanie Heilmann-Heimbach
PD Dr. Stefanie Heilmann-Heimbach
  • Institut für Humangenetik, Universitätsklinikum Bonn
Research topics
  • human genetics
  • male-pattern hair loss
  • multifactorial diseases
My work concentrates on research into the genetic causes of multifactorial diseases. In particular, I focus on the genetic and biological causes of male-pattern baldness, where my research group is one of the world's leading groups in this field. Our investigation of large-scale genetic dataset and the integration of these association data with data on mRNA and microRNA expression from relevant tissues has led to the identification of numerous genes and pathways that are likely to contribute to hair loss in men. I continue to be interested in how these findings can be leveraged to improve prediction and therapy for baldness as well as to understand the shared genetic basis between hair loss and other human traits and dieses. In addition, as head of the Core Facility Next Generation Sequencing I have a great interest in high-throughput sequencing technologies and their application to investigate different omics levels.
Selected publications

Henne SK, Aldisi R, Sivalingam S, Hochfeld LM, Borisov O, Krawitz PM, Maj C, Nöthen MM, Heilmann-Heimbach S (2023) Analysis of 72,469 UK Biobank exomes links rare variants to male-pattern hair loss. Nat Commun. 14(1):5492.

Hochfeld LM, Bertolini M, Broadley D, Botchkareva NV, Betz RC, Schoch S, Nöthen MM, Heilmann-Heimbach S (2021) Evidence for a functional interaction of WNT10A and EBF1 in male-pattern baldness. PLoS One. 16(9):e0256846.

Heilmann-Heimbach S, Herold C, Hochfeld LM, Hillmer AM, Nyholt DR, Hecker J, Javed A, Chew EG, Pechlivanis S, Drichel D, Heng XT, Del Rosario RC, Fier HL, Paus R, Rueedi R, Galesloot TE, Moebus S, Anhalt T, Prabhakar S, Li R, Kanoni S, Papanikolaou G, Kutalik Z, Deloukas P, Philpott MP, Waeber G, Spector TD, Vollenweider P, Kiemeney LA, Dedoussis G, Richards JB, Nothnagel M, Martin NG, Becker T, Hinds DA, Nöthen MM. (2017) Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness. Nat Commun. 8:14694.

Heilmann S, Drichel D, Clarimon J, Fernández V, Lacour A, Wagner H, Thelen M, Hernández I, Fortea J, Algret M, Blesa R, Mauleón A, Roca MR, Kornhuber J, Peters P, Heun R, Föhlich L, Hüll M, Heneka MT, Rüther E, Riedel-Heller S, Scherer M, Wiltfang J, Jessen F, Becker T, Tárraga L, Boada M, Maier W, Lleó A, Ruiz A, Nöthen MM, Ramirez A (2015) PLD3 in non-familial Alzheimer’s disease. Nature 520(7545):E3-5.

Stefanie Heilmann-Heimbach
PD Dr. Stefanie Heilmann-Heimbach
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