Sabine Krabbe
Dr. Sabine Krabbe
  • Deutsches Zentrum für Neurodegenerative Erkrankungen e. V. (DZNE)
Research topics
  • learning
  • decision making
  • Parkinson's Disease
Our research group is interested in the neural circuit mechanisms mediating adaptive learning and state-dependent decision-making in health and disease. To understand how neuronal networks integrate internal states with environmental cues to gate adequate behavioral output, we comprehensively map the functional diversity of defined cell types – ranging from the precise connectivity and molecular profiles of individual neurons to the activity patterns of large neuronal populations during a variety of behavioral tasks. To this end, we combine state-of-the-art circuit neuroscience tools such as in vivo deep-brain calcium imaging in behaving mice with opto- and pharmacogenetics, anatomical tracings as well as electrophysiological, molecular and histological techniques.
Selected publications

Wang Y, Krabbe S, Eddison M, Henry FE, Fleishman G, Lemire AL, Wang L, Korff W, Tillberg PW, Lüthi A, Sternson SM (2023). Multimodal mapping of cell types and projections in the central nucleus of the amygdala. Elife Jan 20;12.

Krabbe S*, Paradiso E*, D’Aquin S, Bitterman Y, Courtin J, Xu C, Yonehara K, Markovic M, Eichlisberger T, Müller C, Gründemann J, Ferraguti F, Lüthi A (2019). Adaptive disinhibitory gating by VIP interneurons permits associative learning. Nature Neuroscience 22(11):1834-1843.

Vogel E*, Krabbe S*, Gründemann J, Wamsteeker Cusulin JI, Lüthi A (2016). Projection-specific dynamic regulation of inhibition in amygdala micro-circuits. Neuron 91(3):644-51.

Krabbe S, Duda J, Schiemann J, Poetschke C, Schneider G, Kandel ER, Liss B, Roeper J, Simpson EH (2015). Increased dopamine D2 receptor activity in the striatum alters the firing pattern of dopamine neurons in the ventral tegmental area. PNAS 112(12):E1498-506.

Sabine Krabbe
Dr. Sabine Krabbe
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