en
Reinhard Bauer
PD Dr. Reinhard Bauer

Website

Affiliations
  • Life & Medical Sciences Institute (LIMES)
Research topics
  • energy homeostasis
  • lipid metabolism
  • neurodevelopment
We want to elucidate on a molecular basis how changes of energy homeostasis affect development (neurodevelopment) and transition to pathological phenotypes. Studies on enzymes in the ceramide-synthesizing pathway indicate that it serves as an important sensor of the lipid status. We identified the Drosophila Ceramide Synthase (CerS) enzyme Schlank as transcriptional regulator sensing lipid levels and transducing the information to the level of gene expression via its homeodomain. , Our research focus is on the role of CerS and its signaling networks for obesity and in neurodevelopment (neurodegeneration) in combination with gap junctions. To address our questions we use the genetic model system fruit fly in combination with FACS sorting, protein- and lipid-biochemistry, cell biology, as well as microscopic techniques.
Selected publications

Sociale M, Wulf AL, Breiden B, Klee K, Thielisch M, Eckardt F, Sellin J, Bülow MH, Löbbert S, Weinstock N, Voelzmann A, Schultze J, Sandhoff K, *Bauer R (2018). Ceramide Synthase Schlank Is a Transcriptional Regulator Adapting Gene Expression to Energy Requirements. Cell Rep. 22: 967-978

Voelzmann A, Wulf AL, Eckardt F, Thielisch M, Brondolin M, Pesch YY, Sociale M, *Hoch M, *Bauer R. (2016) Nuclear Drosophila CerS Schlank regulates lipid homeostasis via the homeodomain, independent of the lag1p motif. FEBS Lett. 590: 971-981

*Bauer R , Voelzmann A, Breiden B, Schepers U, Farwanah H, Hahn I, Eckardt F, Sandhoff K, Hoch, M (2009) Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila. EMBO J. 28: 3706-3716

Löer B, Bauer R, Bornheim R, Grell J, Kremmer, K, Kolanus W & Hoch M (2008), A pivotal role of the NHL-domain protein Wech for the integrin-cytoskeleton link. Nat Cell Biol. 10: 422-128

Reinhard Bauer
PD Dr. Reinhard Bauer

Website

-