Paolo Salomoni
Prof. Dr. Paolo Salomoni
  • Deutsches Zentrum für Neurodegenerative Erkrankungen e. V. (DZNE)
Research topics
  • chromatin dynamics
  • neurodegenerative diseases
  • epigenomics
  • ageing
Since 2017, Paolo Salomoni is heading the Nuclear Function group at the German Center for Neurodegenerative Diseases (DZNE). The main remit of his laboratory is investigating chromatin dynamics in homeostatic as well as pathological conditions, with emphasis on the brain and the innate immune system. More recent work focuses on the role of intrinsic immunity mechanisms controlling accessibility to endogenous retroelements in the genome and how disruption of such mechanisms contributes to inflamm-aging and age-associated conditions. His work carries multiple implications ranging from understanding disease etiology to the identification of chromatin vulnerabilities that could be exploited for development of new treatments. His studies comprise mouse models, patient-derived material and state-of-the art (epi)genomics, the latter supported by strong bioinformatics/computational biology core.
Selected publications

Pathania M, De Jay N, Maestro N, ….. Kleinman C, Jabado N*, Salomoni P*. H3.3K27M cooperates with p53 loss and PDGFRA gain in mouse embryonic neural progenitor cells to induce invasive high-grade gliomas (2017). Cancer Cell, 13;32(5):684-700.e9. doi: 10.1016/j.ccell.2017.09.014. *Joint corresponding.

Amodeo V, Deli A, Betts J,…., Nicotera P, Michod D, Brandner S, Salomoni P. A PML/Slit axis controls physiological cell migration and cancer invasion in the CNS. Cell Reports. 2017 20:411-426. doi: 10.1016/j.celrep.2017.06.047. Cover article

Michod D, Bartesaghi S, Khelifi A, Bellodi C, Berliocchi L, Nicotera P, Salomoni P. (2012). Calcium-dependent dephosphorylation of the histone chaperone DAXX regulates H3.3 loading and transcription upon neuronal activation. Neuron, 74 (1), 122-135. doi:10.1016/j.neuron.2012.02.021

Regad T, Bellodi C, Nicotera P, Salomoni P (2009). The tumor suppressor Pml regulates cell fate in the developing neocortex.. Nat Neurosci, 12 (2), 132-140. doi:10.1038/nn.2251

Paolo Salomoni
Prof. Dr. Paolo Salomoni
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