Oliver Dominik Caspari
Dr. Oliver Dominik Caspari
  • Institut für Mikrobiologie und Biotechnologie
Research topics
  • chloroplast protein import
  • green algae
  • symbiosis
The research focus is on understanding and changing close dependencies between microbiological entities. This involves the interaction of microbes in symbiotic relationships, but the main focus is on endosymbiotic organelles (i.e. chloroplasts and mitochondria) and their embedding within eukaryotic cells. The photosynthetic green microalga Chlamydomonas reinhardtii is our most important model system. Our current research focuses on the mechanism and evolution of protein import into chloroplasts. Analogously, we are investigating whether protein import can be generated in the model bacterium Escherichia coli. Protein import in bacteria is expected to provide a new way to establish dependencies between interacting microbial species. Methodologically, fluorescence microscopy, biochemical and molecular approaches, physiological measurements and experimental evolution are being used.
Selected publications

Caspari OD, Garrido C, Law CO, Choquet Y, Wollman FA, Lafontaine I (2023) Converting antimicrobial into targeting peptides reveals key features governing protein import into mitochondria and chloroplasts. Plant Comm 4:100555.

Caspari OD (2022) Transit Peptides Often Require Downstream Unstructured Sequence for Efficient Chloroplast Import in Chlamydomonas reinhardtii. Front Plant Sci 13:825797.

Garrido C*, Caspari OD*, Choquet Y, Wollman FA, Lafontaine I (2020) Evidence supporting an antimicrobial origin of targeting peptides to endosymbiotic organelles. Cells 9:1795. *equal contributions

Caspari OD, Meyer MT, Tolleter D, Wittkopp TM, Cunniffe NJ, Lawson T, Grossman AR, Griffiths H (2017) Pyrenoid loss in Chlamydomonas reinhardtii causes limitations in CO2 supply, but not thylakoid operating efficiency. J Exp Bot 68:3903-3913.

Oliver Dominik Caspari
Dr. Oliver Dominik Caspari
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