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Oliver Brüstle
Prof. Dr. Oliver Brüstle
TRA Steering Committee

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Affiliations
  • Institut für Rekonstruktive Neurobiologie, Universitätsklinikum Bonn
Research topics
  • stem cells
  • cell reprogramming
Our work focuses on the use of human pluripotent stem cells for neuroregeneration and CNS disease modeling. To that end we employ classic iPSC reprogramming and neural differentiation, transcription factor-based forward programming and direct somatic cell fate conversion. Neuronal and glial subtypes are used to devise new transplant strategies and to study mechanisms underlying neurodegenerative and neuropsychiatric diseases in 2D and 3D cell culture models.
Selected publications

Flitsch, L.J., Laupman, K.E., Brüstle, O. (2020) Transcription factor-based fate specification and forward programming for neural regeneration. Front Cell Neurosci. 14:121. doi.org/10.3389/fncel.2020.00121.

Sheng, C., Jungverdorben, J., Wiethoff, H., Lin, Q., Flitsch, L.J., Eckert, D., Hebisch, H., Fischer, J., Kesavan, J., Weykopf, B., Schneider, L., Holtkamp, D., Beck, H., Till, A., Wüllner, U., Ziller, M.J., Wagner, W., Peitz, M., Brüstle, O. (2018) A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation Nat Commun. 29:4047. doi: 10.1038/s41467-018-06398-5.

Doerr, J., Schwarz, M.K., Wiedermann, D., Leinhaas, A., Jakobs, A., Schloen, F., Schwarz, I., Diedenhofen, M., Braun, N.C., Koch, P., Peterson, D.A., Kubitscheck, U., Hoehn, M., Brüstle, O. (2017) Whole-brain 3D mapping of human neural transplant innervation. Nat Commun. 8:14162. doi: 10.1038/ncomms14162.

Ladewig, J., Koch, P., Brüstle, O. (2014) Auto-attraction of neural precursors and their neuronal progeny impairs neuronal migration. Nature Neuroscience 17(1):24-26. doi: 10.1038/nn.3583.

Oliver Brüstle
Prof. Dr. Oliver Brüstle
TRA Steering Committee

Website

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