Lino Teichmann
Dr. Lino Teichmann
  • Medizinische Klinik und Poliklinik III, Universitätsklinikum Bonn
Research topics
  • innate immunity
  • immune signaling
My group is studying the mechanisms how activation of innate immune sensors in chronic diseases such as systemic lupus erythematosus (SLE), ANCA-associated vasculitis (AAV) and myeloproliferative neoplasms (MPN) induces sterile inflammation and drives disease development. In previous work we could demonstrate that in SLE dendritic cells are critical for augmenting but not initiating disease, defined the specific contributions of B cell- and dendritic cell-intrinsic TLR-MyD88 signaling to self-reactive B and T cell stimulation in SLE, and revealed how intercellular cGAMP transmission contributes to tissue inflammation in Trex1-associated autoimmunity.
Selected publications

Teichmann LL, Cullen JL, Kashgarian M, Dong C, Craft J, Shlomchik MJ (2015) Local Triggering of the ICOS Coreceptor by CD11c(+) Myeloid Cells Drives Organ Inflammation in Lupus. Immunity 42:552–565.

Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA (2014) Development and function of human innate immune cells in a humanized mouse model. Nat Biotechnol 32:364–372.

Teichmann LL, Schenten D, Medzhitov R, Kashgarian M, Shlomchik MJ (2013) Signals via the Adaptor MyD88 in B Cells and DCs Make Distinct and Synergistic Contributions to Immune Activation and Tissue Damage in Lupus. Immunity 38:528–540.

Teichmann LL, Ols ML, Kashgarian M, Reizis B, Kaplan DH, Shlomchik MJ (2010) Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damage. Immunity 33:967–978.

Lino Teichmann
Dr. Lino Teichmann
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