Kerstin Wilhelm-Jüngling
Prof. Dr. Kerstin Wilhelm-Jüngling
  • Institut für Neurovaskuläre Zellbiologie
Research topics
  • vascular biology
  • cell metabolism
  • adipose tissue
Endothelial cells (ECs) are the smallest functional unit of blood and lymphatic vessels. ECs regulate new vessel growth during health and disease. Blood ECs coordinate nurturing of perivascular tissues, while lymphatic ECs regulate fluid homeostasis and immune cell transport. With the development of single cell sequencing, ECs were recognized to be heterogenous within an organism, building organ-specific vasculatures. My research focusses on the metabolic peculiarities of blood and lymphatic ECs in different vascular beds. In particular, I am interested how ECs use their metabolism to communicate with neighboring organ-specific cells and how they thereby control organ function. It has been shown that ECs can influence organ function by secreting molecules, also known as (lymph)angiocrine signaling. The aim of my group is to characterize the organ-specific EC secretome influencing organ physiology and to delineate how disturbed (lymph)angiocrine signaling leads to disease.
Selected publications

Wilhelm K, Happel K, Eelen G, Schoors S, Oellerich MF, Lim R, Zimmermann B, Aspalter IM, Franco CA, Boettger T, Braun T, Fruttiger M, Rajewsky K, Keller C, Brüning JC, Gerhardt H, Carmeliet P, Potente M (2016) FOXO1 couples metabolic activity and growth state in the vascular endothelium. Nature 529(7585):216-20.

Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, De Smet F, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, Simons M (2017) FGF-dependent metabolic control of vascular development. Nature 545(7653):224-228.

Helker CSM, Eberlein J, Wilhelm K, Sugino T, Malchow J, Schuermann A, Baumeister S, Kwon HB, Maischein HM, Potente M, Herzog W, Stanier DYR (2020) Apelin drives vascular endothelial cells towards a pro-angiogenic stage. elife 9:e55589.

Kerstin Wilhelm-Jüngling
Prof. Dr. Kerstin Wilhelm-Jüngling
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