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Hubert Schorle
© UKB
Prof. Dr. Hubert Schorle

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Affiliations
  • Pathologie, Universitätsklinikum Bonn
Research topics
  • genetics and epigenetics of germ cell tumors
The research centers around germ cell development and germ cell tumors. As such, we are using germ cell tumor lines to test novel therapy approaches as well as gene-editing in mice to delete genes which are specifically expressed during spermatogenesis. We contribute to the understanding of tumor treatment and enrich the knowledge about genes involved in male fertility.
Selected publications

Funke K, Einsfelder U, Hansen A, Arévalo L, Schneider S, Nettersheim D, Stein V, Schorle H. Genome-scale CRISPR screen reveals neddylation to contribute to cisplatin resistance of testicular germ cell tumours. Br J Cancer. 2023 Jun;128(12):2270-2282. doi: 10.1038/s41416-023-02247-5. Epub 2023 Apr 6. PMID: 37024667

Arévalo L, Merges GE, Schneider S, Oben FE, Neumann IS, Schorle H. Loss of the cleaved-protamine 2 domain leads to incomplete histone-to-protamine exchange and infertility in mice. PLoS Genet. 2022 Jun 28;18(6):e1010272. doi: 10.1371/journal.pgen.1010272. eCollection 2022 Jun. PMID: 35763544

Merges GE, Meier J, Schneider S, Kruse A, Fröbius AC, Kirfel G, Steger K, Arévalo L, Schorle H. Loss of Prm1 leads to defective chromatin protamination, impaired PRM2 processing, reduced sperm motility and subfertility in male mice. Development. 2022 Jun 15;149(12):dev200330. doi: 10.1242/dev.200330. Epub 2022 Jun 20. PMID: 35608054

Langkabel J, Horne A, Bonaguro L, Holsten L, Hesse T, Knaus A, Riedel Y, Becker M, Händler K, Elmzzahi T, Bassler K, Reusch N, Yeghiazarian LH, Pecht T, Saglam A, Ulas T, Aschenbrenner AC, Kaiser F, Kubaczka C, Schultze JL, Schorle H. Induction of Rosette-to-Lumen stage embryoids using reprogramming paradigms in ESCs. Nat Commun. 2021 Dec 16;12(1):7322. doi: 10.1038/s41467-021-27586-w. PMID: 34916498

Hubert Schorle
© UKB
Prof. Dr. Hubert Schorle

Website

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