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Gregor Hagelüken
PD Dr. Gregor Hagelüken

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Affiliations
  • Institut für Strukturbiologie
Research topics
  • immunity
  • infection
  • structural biology
I am a structural biologist interested in the structure and function of membrane transporters and proteins that are related to infection and immunity. A main focus of my group is the uptake of sialic acid by pathogenic bacteria such as Haemophilus influenzae. These bacteria employ a special class of membrane transporters, so called TRAP transporters to scavenge sialic acid from the host organism. H. influenzae and other pathogens incorporate the imported sialic acid into their surface lipopolysaccharides in order to hide from our innate immune response. My group uses X-ray crystallography, a range of biophysical techniques as well as cryo EM to unravel the molecular details behind biological processes.
Selected publications

Rouillon C, Schneberger N, Chi H, Blumenstock K, Da Vela S, Ackermann K, Moecking J, Peter MF, Boenigk W, Seifert R, Bode BE, Schmid-Burgk J-L, Svergun D, Geyer M, White MF and Hagelueken G, "Antiviral signaling by a cyclic nucleotide activated CRISPR protease." Nature (2023) 614:168-174, doi:10.1038/s41586-022-05571-7.

Peter MF, Ruland JA, Depping P, Schneberger N, Severi E, Moecking J, Gatterdam K, Tindall S, Durand A, Heinz V, Siebrasse J-P, Koenig P-A, Geyer M, Ziegler C, Kubitscheck U, Thomas GH and Hagelueken G, "Structural and mechanistic analysis of a tripartite ATP-independent periplasmic TRAP transporter", Nat. Commun. (2022) 13:4471 doi:10.1038/s41467-022-31907-y.

M.F. Peter, C. Gebhardt, J. Glaenzer, N. Schneberger, M. de Boer, G.H. Thomas, T. Cordes, G. Hagelueken, "Triggering closure of a sialic acid TRAP transporter substrate binding protein through binding of natural and artificial substrates", JMB, 2021, https://doi.org/10.1016/j.jmb.2020.166756

G. Hagelueken, B.R. Clarke, H. Huang, A. Tuukkanen, I. Danciu, D.I. Svergun, R. Hussain, H. Liu, C. Whitfield, J.H. Naismith, "A coiled-coil domain acts as a molecular ruler to regulate O-antigen chain length in lipopolysaccharide", Nat. Struct. Mol. Biol. 2015, 22, 50-56. doi: 10.1038/nsmb.2935.

Gregor Hagelüken
PD Dr. Gregor Hagelüken

Website

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