Gabriele Bierbaum
Apl.-Prof. Dr. Gabriele Bierbaum
  • Institut für Med. Mikrobiologie, Immunologie und Parasitologie (IMMIP)
Research topics
  • antibiotic resistance
  • bacterial kinases
Our projects cover several aspects of the growing problem of antibiotic resistance. We are especially interested in the evolution of resistance with a focus on the role of bacterial histidine kinases. These kinases are able to respond to environmental signals and activate regulatory proteins, that in turn mediate adaptation of the cell to the current conditions. Some kinases are able to sense the presence of antibiotics or antibiotic stress and activate resistance mechanisms. We also focus on new therapeutic agents that inhibit these kinases. In addition, we analyze the dissemination of antibiotic resistant bacteria in the environment and the role that environmental/antibiotic stress plays in the evolution of resistance and the selection of resistant bacteria. Furthermore, we analyze the microbiomes in taphonomy studies in cooperation with the paleontologists of the University of Bonn.
Selected publications

Monk IR, Shaikh N, Begg SL, Gajdiss M, Sharkey LKR, Lee JYH, Pidot SJ, Seemann T, Kuiper M, Winnen B, Hvorup R, Collins BM, Bierbaum G, Udagedara SR, Morey JR, Pulyani N, Howden BP, Maher MJ, McDevitt CA, King GF, Stinear TP. (2019) Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus. Nat Commun. 10(1):3067.

Kehl K, Schallenberg A, Szekat C, Albert C, Sib E, Exner M, Zacharias N, Schreiber C, Parčina M, Bierbaum G. (2022) Dissemination of carbapenem resistant bacteria from hospital wastewater into the environment. Sci Total Environ. 806:151339.

Hardt P, Engels I, Rausch M, Gajdiss M, Ulm H, Sass P, Ohlsen K, Sahl HG, Bierbaum G, Schneider T, Grein F. (2017) The cell wall precursor lipid II acts as a molecular signal for the Ser/Thr kinase PknB of Staphylococcus aureus. Int J Med Microbiol. 307:1-10.

Gäb F, Ballhaus C, Stinnesbeck E, Kral AG, Janssen K, Bierbaum G. (2020) Experimental taphonomy of fish - role of elevated pressure, salinity and pH. Sci Rep.10(1):7839.

Gabriele Bierbaum
Apl.-Prof. Dr. Gabriele Bierbaum
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