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Dirk Baumjohann
© J. Saba
Prof. Dr. Dirk Baumjohann

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Affiliations
  • Medizinische Klinik und Poliklinik III, Universitätsklinikum Bonn
Research topics
  • immunology
  • T-helper cells
CD4-positive T helper cells orchestrate the cellular and humoral immune response to various pathogens, including viruses, bacteria, fungi, and parasites. T follicular helper (Tfh) cells provide help to B cells for efficient antibody production during infection or vaccination. However, dysregulated Tfh cells can also cause autoimmunity and allergies. Interestingly, depending on the context, Tfh cell frequencies have been correlated with either positive or negative outcomes of various tumor entities. Tfh cells have also emerged as central intermediaries of other T helper cell-mediated immune responses that involve the generation of certain effector and memory T helper cell populations, a topic that we are studying in the lab utilizing sophisticated in vivo models and various patient cohorts.
Selected publications

Huber JE, Ahlfeld J, Scheck MK, Zaucha M, Witter K, Lehmann L, Karimzadeh H, Pritsch M, Hoelscher M, von Sonnenburg F, Dick A, Barba-Spaeth G, Krug AB, Rothenfußer S, Baumjohann D (2020) Dynamic changes in circulating T follicular helper cell composition predict neutralising antibody responses after yellow fever vaccination. Clin Transl Immunology 9:e1129.

Schmidt A, Huber JE, Sercan Alp Ö, Gürkov R, Reichel CA, Herrmann M, Keppler OT, Leeuw T, Baumjohann D (2020) Human adenoid tissue-based ex vivo culture systems reveal anti-inflammatory drug effects on T and B cells. EBioMedicine 53:102684.

Baumjohann D, Kageyama R, Clingan JM, Morar MM, Patel S, de Kouchkovsky D, Bannard O, Bluestone JA, Matloubian M, Ansel KM, Jeker LT (2013) The microRNA cluster miR-17~92 promotes TFH cell differentiation and represses subset-inappropriate gene expression. Nat Immunol 14:840-848.

Baumjohann D, Preite S, Reboldi A, Ronchi F, Ansel KM, Lanzavecchia A, Sallusto F (2013) Persistent antigen and germinal center B cells sustain T follicular helper cell responses and phenotype. Immunity 38:596–1605.

Dirk Baumjohann
© J. Saba
Prof. Dr. Dirk Baumjohann

Website

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