Christoph Wilhelm
Prof. Dr. Christoph Wilhelm
  • Institut für klinische Chemie und klinische Pharmakologie, Universitätsklinikum Bonn
Research topics
  • innate lymphoid cells
  • chronic inflammation
Long-term experience in the research of a unique group of immune cells termed innate lymphoid cells (ILC). My scientific focus is to understand how these cells protect the body’s barrier sites such as the lung, skin and gut and to understand how exogenous and endogenous metabolites control the function of ILC in health and disease. The overall aim of this research is to understand the link between westernization and the growing health problem of chronic inflammatory conditions such as asthma and inflammatory bowl disease (IBD).
Selected publications

Karagiannis F, Kharabi Masouleh S, Wunderling K, Surendar J, Schmitt V, Kazakov A, Michla M, Hölzel M, Thiele C & Wilhelm C. Lipid droplet formation drives pathogenic type 2 innate lymphoid cells in airway inflammation. Immunity 2020.

Wilhelm C*#, Harrison OJ1#, Pelletier M, Spencer SP, Urban JF Jr, Ploch M, Ramalingam TR, Siegel R, Belkaid Y*. Critical role of fatty acid metabolism in ILC2 mediated barrier protection during malnutrition and helminth infection. J Exp Med 2016. *Corresponding authors, # equal contribution

Spencer SP*, Wilhelm C*, Yang Q, Hall JA, Bouladoux N, Boyd A, Nutman TB, Urban JF Jr, Wang J, Ramalingam TR, Bhandoola A, Wynn TA, Belkaid Y. Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity. Science 2014 *Primary authors contributed equally to this work.

Wilhelm C, Hirota K, Stieglitz B, Van Snick J, Tolaini M, Lahl K, Sparwasser T, Helmby H and Stockinger B. An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nature immunology 2011.

Christoph Wilhelm
Prof. Dr. Christoph Wilhelm
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