Christa E. Müller
Prof. Dr. Christa E. Müller
TRA Steering Committee
  • Pharmazeutisches Institut
Research topics
  • membrane proteins
  • G-protein-coupled receptors
  • chemical analytics
  • medicinal chemistry
My research focus is on medicinal chemistry of membrane proteins. We are interested in purinergic receptors and related G protein-coupled orphan receptors including G proteins, as well as ectonucleotidases involved in purinergic signal transduction. A broad spectrum of methods is utilized for our research projects including chemical synthesis of bioactive molecules and labelled compounds (molecular probes), (bio)analytical studies, assay development, structure analysis of drug-protein complexes, in vitro pharmacology, and molecular biology. In vivo studies of our compounds are performed in collaboration with colleagues in biology and medicine. My group runs two platforms, a chemical analytics platform with a focus on quantitative analysis, and a compound library with a unique collection of small synthetic molecules and natural products.
Selected publications

Zhang K et al. (2014) Structure of the human P2Y12 receptor in complex with an antithrombotic drug. Nature 509:115-118.

Bhattarai, S et al. (2015) a,β-Methylene-ADP (AOPCP) derivatives and analogues: development of potent and selective ecto-5’-nucleotidase (CD73) inhibitors. J Med Chem 58:6248-6263.

Claff T et al. (2019) Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists. Sci. Adv. 5(11):eaax9115. doi: 10.1126/sciadv.aax9115.

Kuschak M et al. (200) Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics and identify small molecule inhibitors. Br J Pharmacol 177:1898-1916.

Christa E. Müller
Prof. Dr. Christa E. Müller
TRA Steering Committee
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