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Marc Hübner
Prof. Dr. Marc Hübner

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Affiliations
  • Institut für Med. Mikrobiologie, Immunologie und Parasitologie (IMMIP)
Research topics
  • tropical medicine
  • filariasis
The focus of my lab is the identification and preclinical testing of new therapies against parasitc helminths, which is done in close collaboration with partners from industry and non-profit organizations. Furthermore, my lab studies protective immune responses against filariae, especially the protective role of eosinophils and the contribution of extracellular DNA traps (ETosis). Finally, I am interested in the filarial immunomodulation and its beneficial impact on life-style diseases such as diet-induced insulin resistance. For our research we use the Litomosoides sigmodontis animal model and conduct studies with filariasis patients with partners in Cameroon.
Selected publications

Scheunemann JF, Risch F, Reichwald JJ, Lenz B, Neumann AL, Garbe S, Frohberger SJ, Koschel M, Ajendra J, Rothe M, Latz E, Coch C, Hartmann G, Schumak B, Hoerauf A, Hübner MP (2023) Potential of Nucleic Acid Receptor Ligands to Improve Vaccination Efficacy against the Filarial Nematode Litomosoides sigmodontis. Vaccines 11.

Ehrens A, Lenz B, Neumann AL, Giarrizzo S, Reichwald JJ, Frohberger SJ, Stamminger W, Buerfent BC, Fercoq F, Martin C, Kulke D, Hoerauf A, Hübner MP (2021) Microfilariae Trigger Eosinophil Extracellular DNA Traps in a Dectin-1-Dependent Manner. Cell reports 34:108621.

Hübner MP, Townson S, Gokool S, Tagboto S, Maclean MJ, Verocai GG, Wolstenholme AJ, Frohberger SJ, Hoerauf A, Specht S, Scandale I, Harder A, Glenschek-Sieberth M, Hahnel SR, Kulke D (2021) Evaluation of the in vitro susceptibility of various filarial nematodes to emodepside. Int J Parasitol Drugs Drug Resist 17:27-35.

Hübner MP, Martin C, Specht S, Koschel M, Dubben B, Frohberger SJ, Ehrens A, Fendler M, Struever D, Mitre E, Vallarino-Lhermitte N, Gokool S, Lustigman S, Schneider M, Townson S, Hoerauf A, Scandale I (2020) Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro. PLoS Negl Trop Dis 14:e0008427.

Marc Hübner
Prof. Dr. Marc Hübner

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