EU Research Projects of the University of Bonn

Research at the University of Bonn includes cooperation with excellent international partners, which is why participation in the EU research framework program Horizon Europe is of great importance.

Collaborative Projects (Coordinator)

Here you can find an overview of the EU collaborative projects that are coordinated by researchers at the University of Bonn.

EU collaborative projects coordinated by the University of Bonn

Law in crisis - Judicial Cultures of Independence and their meaning for the Rule of Law Compliance: Law in crisis

Koordinator
Prof. Dr. jur. Dr. h.c. Werner Gephart
Käte Hamburger Kolleg "Recht als Kultur"
Adenaueralle 131
53113 Bonn

Abstract
Judicial independence in the EU faces structural and cultural pressures that endanger its identity as a community of law. In several Member States, politicised appointments, selective disciplinary measures and unequal access to justice undermine court legitimacy and public trust. The EU-funded Law in crisis project examines judicial independence not only as a constitutional principle but also as an institution rooted in Europe’s diverse legal traditions. Combining comparative legal analysis with empirical indicators, it develops an interdisciplinary framework assessing how independence, impartiality and integrity work in practice. By integrating legal, cultural and societal dimensions, the project identifies blind spots in existing monitoring tools. Its main output – the Judicial Cultures Toolkit – supports institutional self-assessment and strengthens EU rule of law policy and judicial reform.

Funding programme
Horizon Europe: Culture, creativity and society

Duration
01.09.2026 - 31.08.2029

MRDetCon - "Mutual Recognition and Detention Conditions"

Coordinator
Prof. Dr. Martin Böse
Lehrstuhl für Strafrecht und Strafprozessrecht sowie Internationales und Europäisches Strafrecht
Adenauerallee 24-42
53113 Bonn

Abstract
The project aims at contributing to a more effective and coherent application of cooperation instruments where bad detention
conditions are an issue. Ever since the Aranyosi and Căldăraru judgment (CJEU, judgment of 5 April 2016, Joined Cases C-404/15 &
C-659/15 PPU, ECLI:EU:C:2016:198), bad detention conditions can render the European arrest warrant (EAW), but also the mutual
recognition of judgments imposing custodial sentences (FD 2008/909/JHA) ineffective and – given the uneven interpretation of the
aforementioned judgment in the Member States - incoherent.
The project focuses on the specific objective to analyse the practical application of the relevant cooperation instruments (including
measures not involving deprivation of liberty, e.g. transfer of proceedings) in the Member States and to identify defects in the EU and
national legal framework and suboptimal application in practice and to put forward solutions and best practices to remedy these
defects.
Work plan
The work plan provides for the following activities: formulating and answering a questionnaire, drafting and discussion of country
reports, holding meetings with the national academic researchers (NARs) and members of the Sounding Board (SB), final research
report (including recommendations and best practices), e-learning-proposals, European Symposium.
Expected results
• better decisions in the given circumstances of the case, with due regard to the fundamental rights of the person concerned;
• a more proportionate use of the instruments (preferably a non-custodial instrument is applied);
• a reduction of delays, extra efforts and extra costs inherent in application of the two-step test;
• prevention of impunity as much as possible;
• in the end, a strengthening of mutual trust between the competent authorities of the MSs
Benefitting (impact)
• issuing and executing authorities of all MS;
• defence counsels, suspects and convicted persons;
• MS/EU legislator.

Funding programme
Justice Programme

Duration
01.05.2026 - 30.04.2028

ALPHA-FIT - Slowing cognitive decline in alpha-synucleinopathies by enhancing physical activity

Coordinator
PD Dr. Michael Sommerauer
Center for Neurology, Department of Parkinson, Sleep and Movement Disorders
Venusberg-Campus 1
53127 Bonn

Abstract
a-synucleinopathies represent the second most common neurodegenerative disorders. Adding to motor deterioration, cognitive decline is a key element of their non-motor symptom complex. Early detection and intervention to halt accelerated brain-ageing are critical yet unmet needs in these disorders. Optimizing lifestyle factors in individuals with isolated REM sleep behaviour disorder (iRBD) holds great potential as iRBD signals an early stage of an a-synucleinopathy, representing an ideal therapeutic window for prevention strategies.

Specifically, increasing physical activity has shown beneficial effects on various outcomes including preservation of cognitive function in the context of neurodegenerative processes. We will apply a novel strategy to increase physical activity by a remotely applied motivational, gamification-based smartphone app, which has already been established in pilot trials and proven to be both feasible and effective.

Taking advantage of easy application for long-term uses and the large existing cohorts within our consortium, we will conduct a multicentre, randomized, double-blind, active-controlled trial on more than 250 individuals with iRBD evaluating the efficacy of this motivational app to ameliorate cognitive decline over a one-year period. Adding to classic neuropsychological cognitive testing as our primary outcome, we will assess MRI and blood-based markers of brain-ageing. For evaluation of a broader application, we will also test our gamification smartphone app in healthy elderly without known risk-factors for accelerated brain-ageing.

Our study may tremendously change the perspective on early disease detection as a disease-modification intervention will become available, being easy to apply and at low risk for side effects. In addition, we will leverage the mechanistic aspects on how increased physical activity influences brain health and gain insights into the generalizability of our approach for a broader application.

Funding programme
ERA4Health Partnership

Duration
01.04.2025 - 31.03.2028

STRATEGIC - Sustainable eTHics Review of digital heAlth Technology dEsiGn In sub sahara AfriCa

Coordinator
Prof. Dr. Dirk Lanzerath
Deutsches Referenzzentrum für Ethik in den Biowissenschaften
Bonner Talweg 57
53113 Bonn

Abstract

The STRATEGIC project aims to co-create responsible research and innovation approach that aligns with social-cultural values, principles, contexts, needs and interests in SSA and implement capacity development plans that can strengthen the ethics and regulatory capacity to ensure responsible digital health technologies for clinical research and practice. The project will involve SSA and EU partners and stakeholders and co-create functional resources, such as the STRATEGIC training materials. The urgency of strengthening ethics and legal infrastructure for digital health technologies in SSA is due to the increasing integration of digital technologies into clinical research and practice and the potential negative impacts of these systems on patients, communities and society. While most countries in the Global North have recognised the importance of responsible digital health technologies, the ethics and regulatory capacities for addressing the ethical and legal risks of these technologies are still lacking in SSA. The overarching aim of the STRATEGIC project is to co-create a theoretically strong, empirically supported and widely consulted responsible research and innovation approach and capacity development plan and materials that can strengthen relevant ethics and regulatory institutions for clinical research and practice in SSA. It will identify and map the existing ethical and legal infrastructure in SSA, highlighting the gaps and needs; use these insights to co-create an RRI approach and co-develop and implementing trainings that will also be interested into existing training infrastructure and network. It will also establish sustainable e-community that exist beyond the project. Methodologies to be used include, stakeholder engagement and co-creation strategies such as focus groups, consensus workshops and roundtable discussions.

Funding programme
Horizon Europe

Duration
01.04.2024 - 31.03.2027

RE4GREEN - "Research Ethics and integrity for the GREEN transition"

Coordinator
Prof. Dr. Dirk Lanzerath
Deutsches Referenzzentrum für Ethik in den Biowissenschaften
Bonner Talweg 57
53113 Bonn

Abstract

There is growing awareness of the importance of having all sectors of society adapt to face a range of global environmental and climate challenges, taking into account intergenerational justice. These challenges require developing an encompassing framework for research and innovation (R&I) to address environmental and climate ethics and integrity issues, which relate not only to R&I involving potentially significant environmental and climate repercussions (e.g., R&I in the area of electro-magnetic fields), but also R&I specifically aiming to develop knowledge and technologies to address environmental and climate challenges (e.g., geoengineering or biotechnology in food systems). RE4GREEN’s main goal is to contribute to a European Research Area (ERA) ethics and integrity framework for research and innovation activities designed to support the transition to a sustainable economy and society as envisioned by the European Green Deal. While R&I has too often been part of the problem of environmental degradation and biodiversity loss, a central pillar of the European Green Deal and associated legislation is to promote new technologies and sustainable solutions to reach net zero emissions in the EU by 2050, and advance a range of other climate and environmental objectives. Based on a bottom-up approach that uses the social lab methodology to reflect diverse stakeholder expertise, RE4GREEN will develop operational research ethics and integrity guidelines, recommendations and training materials and programmes for researchers, ethics and integrity experts and advisors and ethics review boards to make sure R&I activities more holistically contribute solutions toward the Green Transition.

Funding programme
Horizon Europe

Duration
01.02.2024 - 31.01.2027

eWHORM - "enabling the WHO-Roadmap 2023"

Coordinator
Prof. Dr. Marc Hübner
Institut für Medizinische Mikrobiologie, Immunologie und Parasitologie
Universitätsklinikum Bonn
Venusberg - Campus 1
53127 Bonn

Abstract

We will establish for the first time in NTDs an adaptive clinical trial platform and improve clinical research infrastructure in four SSA countries. A drug acting safely on multiple helminths species would be a major leap to tackle NTDs and enable the WHO RoadMap (eWHORM). The cheap and freely-accessible pan-nematode drug oxfendazole (OXF) has such potential. Given the limited portfolio of anthelmintic drug candidates, eWHORM will assess its efficacy in an adaptive clinical trial for simultaneous evaluation against onchocerciasis, loiasis, mansonellosis and trichuriasis. Thus not only the largest group of NTDs, but also diseases that are not (yet) listed will be adressed. This design significantly reduces patient numbers, development time-frames and enables treatment of co-infections. Combined with our highly sensitive molecular tests, we provide a patient-centric approach providing tools for targeted treatment (test and treat) and precision mapping for elimination programs. Strengthening of early career scientists in SSA in all aspects of clinical trial conduct and research including data management, simulation and statistical analysis, will be fostered by introducing a master and PhD program, a mentorship program as well as several webinars. An open-source virtual training and assessment tool for diagnosis of NTDs
will complement the knowledge transfer to remote areas in SSA. The consortium encompasses an interdisciplinary partnership from eight different countries (Germany, the Netherlands, Austria, Switzerland, Cameroon, Gabon, Tanzania, and DRC). Each group brings unique knowhow and recognized complementary experience to the project to ensure sustainable capacity building within SSA countries. Through joint development of – and training in – modern, regulatory clinical trial conduct, adaptive clinical trial design and state-of-theart diagnostics, we will strengthen SSA researchers and clinicians to respond to persisting and future health challenges.

Funding programme
Horizon Europe

Duration
01.04.2023 - 31.03.2028

Collaborative Projects (Partner)

Researchers of the University of Bonn are also involved in numerous EU collaborative research projects as partners. Find out more about the various projects here.

EU collaborative projects in which the University of Bonn is a partner

BRICKS - BRICKS: Building Robotic Intelligence and Modular Construction Kit System

Partner
Prof. Dr. Sven Behnke
Insitute of Computer Science -
Department VI - Inteligent Systems and Robotics
Friedrich-Hirzebruch-Allee 8
53115 Bonn

Abstract
The construction sector faces urgent challenges, including labour shortages, low productivity, high accident costs, and sustainability pressures. BRICKS addresses these through a novel approach to faster, safer, and more efficient construction based on advanced robotic systems, digitally enabled building components, data-driven planning, intelligent control, and coordinated multi-agent operation. The BRICKS methodology brings together complementary innovations in construction system design, robotic assembly, digital workflow integration, adaptive autonomy, and human-robot collaboration. It will enable reliable handling and assembly of modular building elements, flexible robotic operation across different construction conditions, and continuous alignment between design intent and on-site execution. The approach also supports robust perception, adaptive decision-making, and coordinated task execution in complex and changing environments, while ensuring safe interaction with human workers. Together, these advances will establish a scalable and flexible construction ecosystem targeting high-risk, high-reward innovation. BRICKS’s disruptive approach redefines on-site building design and assembly to ensure interoperability, adaptability, safety, and efficiency. The integrated ecosystem will be validated at TRL4 through compatible pilots, showcasing autonomous multi-robot-human assembly using a construction kit specifically conceived for robotic deployment.

Funding programm
Horizon Europe: EIC- Pathfinder Challenge

Coordinator
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

Duration
01.11.2026 - 30.04.2030

HADRON-2030 - "Access to physics with hadrons at the frontier of knowledge : fundamental research and applications"

Partner
Prof. Dr. Bernhard Ketzer
Prof. Dr. Carsten Urbach
Helmholtz-Institut für Strahlen- und Kernphysik
Nußallee 14-16
53115 Bonn

Prof. Dr. Klaus Desch
Physikalisches Institut
Käthe-Kümmel-Straße 1
53115 Bonn

Abstract
The strong interaction is one of the cornerstones of the Standard Model (SM) of particle physics, and its experimental and theoretical
study attracts an active community of about 2.500 researchers in Europe. The list of open fundamental questions at the frontier of our
current knowledge in the strong interaction is very rich. It includes (i) the structure of hadrons (ii) exotic hadron states, (iii) properties
of dense quark matter, (iv) hot and dense quark-gluon plasma, and (v) precision tests of the SM in the quest for physics beyond the SM.
Such research topics are studied with particle accelerators from very low energies up to the high energies in the multi-TeV regime at
the LHC. The consortium includes 15 transnational facilities located in Europe and United States out of which 3 are ESFRI landmark
infrastructures. It includes also 6 Virtual Access infrastructures and 49 academic or research organizations. HADRON-2030 aims at
critically advancing our fundamental understanding of the strong interaction by offering Transnational Access (TA) to flagship facilities
and by coherent development of the research resources, thereby increasing knowledge exchange between EU groups and maximising
scientific progress. The project also exploits the innovation potential in applied research by engaging with EU industry for the production
of detector systems and by developing applications beyond fundamental physics, e.g. for medical imaging. HADRON-2030 will lead to
enhanced coordination within the European hadron, nuclear and particle physics communities, leveraging EU and national resources. The
project will explore the limits of our current understanding of the strong interaction and hadrons, develop novel detector technologies, and
will provide access to the world-class infrastructure, benefiting thousands of researchers participating in ongoing and future fundamental
physics projects, and contributing to maintaining Europe's leadership in the field.

Funding Programme
Horizon Europe

Coordinator
CENTRA NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS

Duration
01.10.2026 - 30.09.2030

EUcanAI - European Unified Cancer diagnostics and treatment AI agent  

Partner
Prof. Dr. Philipp Vollmuth
Klinik für Neuroralogie
Venusberg-Campus 1
53127 Bonn

Abstract
The EUcanAI project pioneers a new paradigm for clinical management of central nervous system (CNS) cancers by creating a modular, agentic Generative AI ecosystem that unifies diagnosis and treatment into an integrated continuum of care. Current workflows in neuro-oncology are fragmented, slow, and highly dependent on individual expertise, leading to variable outcomes. EUcanAI transforms this landscape by developing interoperable AI agents that interact across three technological domains: (i) multimodal integration through an orchestration agent capable of synthesising clinical, imaging, histopathological and molecular data into transparent tumour board recommendations; (ii) medical data augmentation via generative models that produce synthetic MRI sequences, FFPE-quality histology from frozen sections, and rare diagnostic scenarios for model training and benchmarking; and (iii) knowledge representation and reasoning frameworks aligned with WHO CNS tumour classifications, ensuring transparent provenance, reproducibility, and explainable decision support.
The consortium unites 13 leading institutions across 3 EU Member States (Germany, Austria, Denmark), 1 Associated Partner (Korea), and 1 international collaborator (WHO-IARC), ensuring regional diversity, complementary expertise, and global external validation. This partnership enables access to the largest harmonised CNS tumour datasets in Europe (>10,000 cases) and world-class clinical infrastructures for multi-centre validation.
Through staged retrospective and prospective studies, EUcanAI will deliver clinically validated, human-in-the-loop AI systems supporting every step of CNS cancer care—from patient history extraction to intraoperative diagnostics and therapeutic planning. By embedding regulatory compliance with the EU AI Act, MDR and GDPR from inception, EUcanAI ensures trustworthy, sovereign and clinically adoptable AI.

Funding programme
Horizon Europe: EIC- Pathfinder Challenges

Coordinator
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG

Duration
01.09.2026 - 31.08.2030

Incognito Justice - Incognito Justice: How Party Anonymity Impacts Judicial Independence and the Rule of Law

Partner
Jun.-Prof. Dr. Svenja Hippel
CASTLE - Center for Advanced Studies in Law and Economics
Adenauerallee 24-42
53113 Bonn

Abstract
Open justice is a fundamental principle of democratic governance. Across the European Union, however, courts often anonymise litigants’ names. This practice is usually framed as a trade-off between privacy and transparency. The EU-funded Incognito Justice project challenges this view by examining how judicial anonymisation affects independence, accountability, consistency and public trust. Combining comparative legal analysis, computational methods and behavioural experiments amongst the public, judiciaries and the media, it investigates whether anonymity protects judges from external pressures or, by reducing scrutiny, allows bias to influence decisions. As the first comprehensive interdisciplinary assessment of judicial anonymisation, the project will provide evidence to inform European policy while deepening understanding of a procedural practice with significant implications for the rule of law.

Funding programme
Horizon Europe: Curlture, creativity and inclusive society

Coordinator
THE HEBREW UNIVERSITY OF JERUSALEM

Duration
01.09.2026 - 31.08.2029

SOILBIOMASS+ - Co-creating Sustainable Biomass Production and Soil Health Restoration for Diverse European Lansdcapes

Partner
Prof. Dr. Eike Luedeling
INRES - Horticultural Sciences
Auf dem Hügel 6
53121 Bonn

Abstract
SOILBIOMASS+ will accelerate Europe’s transition to sustainable biomass production systems that enhance soil health and climate resilience. In line with the EU Mission “A Soil Deal for Europe,” the project will co-design, test and validate land management practices, modelling tools and decision-support systems that enable farmers, foresters, landowners and policy-makers to make informed choices balancing productivity, environmental goals and socio-economic viability. The consortium brings together a strong Multi-Actor network of universities, research organisations, SMEs, NGOs and land managers, and directly embeds nine Living Labs (LLs) and Demonstration Sites (DSs) across eight European countries. These sites cover Europe’s main pedo-climatic zones and land-use types, including arable land, agroforestry, forestry, and peatlands, providing long-term datasets, real-world testing and active stakeholder communities. This ensures that project outcomes will be scientifically sound, socially relevant and scalable. The methodology combines three pillars: (i) evidence generation through improved indicators, scenario modelling and EU-scale mapping; (ii) co-design and validation of practices, value chains and business cases in LLs and DSs with systematic stakeholder engagement; and (iii) deployment and scaling through decision-support tools, policy recommendations and cross-fertilisation with other Mission Soil initiatives (e.g. LILAS4SOILS, AI4SoilHealth). Expected impacts include new approaches for sustainable biomass and soil management tailored to local contexts, validated tools for monitoring and informed decision-making, strengthened value chains, and a science–policy dialogue for soil health and bioeconomy strategies. By bridging evidence, practice, and policy, SOILBIOMASS+ will contribute to Mission Soil targets, the Green Deal, and the Circular Bioeconomy, while empowering farmers, land managers, and foresters as agents of change.

Funding programme
Horizon Europe: Food, Bioeconom Natural Resources, Agriculture and Environment - Mission Soil

Coordinator
THE UNIVERSITY OF READING

Duration
01.09.2026 - 31.08.2030

AccordiAgriScienceFM - AI Foundation Models in Agricultural Sciences  on-Title

Partner
Prof. Dr. Ines Danquah
Hertz-Professorin "Innovation for Planetary Health" in der TRA Sustainable Futures
Center for Development Research (ZEF)
Genscherallee 3
53113 Bonn

Abstract
The IRIS Africa project aims to bridge the gap in Generative AI (GenAI) adoption across Africa, focusing on empowering rural populations, women, and youth through tailored AI solutions in agriculture and healthcare. By developing context-specific Large Language Models (LLMs) and risk-classification algorithms, IRIS will enhance local capacities in addressing challenges such as food insecurity and limited healthcare access, which are exacerbated by climate change and socio-economic barriers.

The project will leverage the existing EU-based LLM models MINERVA and BABELNET and adapt them to the African context through co-design with local communities, ensuring linguistic and cultural relevance. The use of these models and a risk classification algorithm will be tested through two key use cases: Continuous Glucose Monitoring (CGM) in Ghana and livestock insurance in Kenya, targeting areas with the highest need for scalable, AI-driven solutions. In collaboration with local universities, NGOs, International Research Center and SMEs, IRIS will ensure that these AI tools are not only technically sound but also accessible and trusted by the communities they aim to serve.

A key objective is to foster sustainable local innovation ecosystems, including the establishment of living labs and engagement of private investors and VC to support for African start-ups, by integrating technical support mechanisms and subcontracting of local SMEs. Through these activities, IRIS will promote knowledge transfer between Africa and Europe, facilitating long-term, self-sustaining AI capabilities. The project also aims to develop policy recommendations that will support the scaling of GenAI technologies, aligning with EU and African Union frameworks for sustainable development.

IRIS will contribute to the EU-Africa collaboration agenda, supporting Africa's digital transformation by ensuring that advanced AI solutions meet local needs, promote inclusion, and contribute to sustainable economic growth.

Funding programme
Horizon Europe: Digistal, Industry and Space

Coordinator
SUSTAINABLE TRANSITION SOCIETA' COOPERATIVA

Duration
01.05.2026 - 30.04.2029

IRIS Africa - Intelligent and Responsible Innovation with GenAI for Societal impact

Partner
Prof. Dr. Ines Danquah
Hertz-Professorin "Innovation for Planetary Health" in der TRA Sustainable Futures
Center for Development Research (ZEF)
Genscherallee 3
53113 Bonn

Abstract

The IRIS Africa project aims to bridge the gap in Generative AI (GenAI) adoption across Africa, focusing on empowering rural populations, women, and youth through tailored AI solutions in agriculture and healthcare. By developing context-specific Large Language Models (LLMs) and risk-classification algorithms, IRIS will enhance local capacities in addressing challenges such as food insecurity and limited healthcare access, which are exacerbated by climate change and socio-economic barriers.

Funding programm
Horizon Europe: Digistal, Industry and Space

Coordinator
SUSTAINABLE TRANSITION SOCIETA' COOPERATIVA

Duration
01.05.2026 - 30.04.2029

OutMARCH - "OutMARCH-ing cancer: Towards innovative membrane protein degrader modalities for cancer treatmenttel"

Partner
Prof. Dr. Florian I. Schmidt
Institute of Innate Immunity
Venusberg-Campus 1
53127 Bonn

Abstract
The OutMARCH project pioneers a paradigm-shifting protein degradation technology aimed at transforming the therapeutic landscape for cancer and beyond. By engineering a novel class of bispecific antibodies—SureTACs—that harness membrane-bound E3 ubiquitin ligases to selectively degrade disease-driving surface proteins. This groundbreaking lysosomal-targeting approach offers greater selectivity, durability, and breadth than conventional blocking therapies and, moreover, enables the targeting of previously 'undruggable' proteins. Central to our innovation is the utilization of the MARCH family of membrane-bound E3 ligases—an unconventional class of enzymes with remarkable substrate promiscuity and cancer-selective expression profiles. These properties make MARCH E3s ideal effectors for tissue-specific protein degradation, reducing off-target toxicity and overcoming treatment resistance. To unlock their therapeutic potential, we will develop a modular platform combining antibody engineering, innovative screening technologies, and machine-learning-guided design. The result will be a new class of biologics that direct the body’s own cellular machinery to dispose of harmful proteins.
Our initial focus is on two urgent oncology needs: therapy-resistant B-cell lymphomas and difficult-to-treat gastrointestinal cancers. Both cancer types rely on critical cell surface signaling hubs that evade traditional drug targeting. By degrading cancer-driving proteins at the cell surface, we aim to drive tumor-specific protein elimination to achieve durable anti-cancer effects. Using AI-guided antibody design and optimized E3-target pairing screens, OutMARCH will establish the first programmable, modular membrane degrader platform. While currently focused on oncology, this platform has broad potential across autoimmunity, transplantation, and chronic inflammation—paving the way for a new era of programmable degradation in precision medicine.

Funding programme
Horizon Europe

Koordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT

Laufzeit
01.05.2026 -30.04.2030

EUMAplus - "Creating Open Access Digital Educational Material in Disaster Risk Management and Civil Protection"

Partner
Prof. Dr. Lothar Schrott
Geogrphisches Institut
Meckenheimer Allee 166
53115 Bonn

Abstract

Civil protection systems across Europe are facing growing challenges due to the increasing frequency and complexity of disasters and crises. Besides other factors, environmental degradation, climate change, demographic shifts, geopolitical developments, and pandemics all contribute to these evolving risks. In this dynamic landscape, public awareness, together with a highly skilled and well-prepared workforce, is crucial for effective crisis anticipation, preparedness, response, and recovery. Providing comprehensive, high-quality, and easily accessible educational material to the public, practitioners, and other interested parties is therefore essential for strengthening disaster risk management and civil protection capacities, enhancing resilience, and increasing preparedness to address emerging threats.

The EUMAplus project actively supports the objectives of the EU Preparedness Strategy by developing freely accessible, science-based educational resources for a broad and diverse audience. By doing so, it fosters a culture of preparedness and resilience across societies and aligns with several strategic aims of this Strategy, such as integrating preparedness into the training of educational staff and increasing public awareness of risks. By making educational materials broadly available to various stakeholders, EUMAplus also contributes to the long-term sustainability and effectiveness of the Union Civil Protection Mechanism’s (UCPM) results.

Across the European Union, EUMAplus will strengthen basic knowledge and public understanding of disaster risk management and civil protection, including prevention and preparedness. This will be achieved through the development of easy-to-understand, open-access digital education materials, ensuring broad, inclusive, and no-cost accessibility. Educational resources will include a Massive Open Online Course (MOOC) and a Podcast series, both of which will be freely available on commonly used platforms and disseminated widely across disaster risk management and civil protection networks. The course will be recorded in English and partly in the partners' languages (German, Italian, Dutch, Hungarian), with subtitles available in English, French, German, Italian, Spanish, Hungarian, and Polish. As flexible and remote work models evolve across Europe, a feasibility study will explore using AI avatars to create adaptable, multi-language educational videos. Further, an open-access textbook, containing a general strategy for developing digital educational material in the context of disaster risk management and civil protection, will be published.

By serving as an accessible introduction to disaster risk management and civil protection for the general public and offering a solid foundation for staff members of respective authorities and individuals seeking further academic training, EUMAplus will foster the strategic upscaling of preparedness capacities within the Union over the next decade, in line with the conclusions of the 2024 Commission Communication on the evaluation of the UCPM.

The project directly addresses the European Union Disaster Resilience Goal 2 "Prepare," aiming to "increase risk awareness and preparedness of the population," and targets both formal and informal learning environments. Through cross-country collaboration among five universities, EUMAplus embodies the European Commission’s call for integrated and coordinated efforts in civil protection and disaster risk reduction.

Funding programme
European Civil Protection Mechanism

Coordinator
Universität Wien

Duration
26.01.2026 - 25.01.2028

GRACE - "bridGing gaps in caRdiAC health managEment"

Partner
Prof. Dr. Julian Luetkens
Klinik für Diagnostische und Interventionelle Radiologie
Venusberg-Campus 1
53127 Bonn

Abstract

The GRACE integrated solution aims to transform the healthcare ecosystem by providing essential knowledge and innovative public-private partnership for (1) reorganizing healthcare services (2) with embedded innovative technologies and tools, helping identifying and overcoming barriers and gaps that are now hindering CVD management, ensuring a seamless continuum of care and optimized care pathways. Our vision is that introducing effective health technology and interventions is economically, societally and environmentally sustainable if and only accompanied by a substantial healthcare service re-organization. Accordingly, GRACE will focus on an end-to-end clinical pathway CVD, considering an holistic view of the patient and optimizing healthcare services leveraging on advanced technological solutions. GRACE intervention will be multifold aiming at: (1) guiding strategic policies, (2) drive market innovation, and (3) foster effective healthcare delivery practices in CVD, generating value for patients, healthcare workers and system. GRACE will enable early and personalized interventions, fostering coordination of multidiscipline healthcare teams, triggering more intense and person-specific management using innovative technologies, AI and digital solutions for early detection of red flags, promoting patient empowerment, while comprehensively containing CVD risk factors and burden. A multidisciplinary consortium of experienced and competitive partners will implement this vision and implement the proposed solution in a novel multidiscipline manner.

Funding programme
Horizon Europe

Partner
UNIVERSITA CAMPUS BIO MEDICO DI ROMA

Duration
01.02.2025 - 31.07.2029

REFINE - "Receptor-Focused Interventions Against Orthoflavivirus Neuroinvasion and Entry"

Partner
Prof. Dr. Florian Schmidt
Institute of Innate Immunity
Venusberg-Campus 1
53127 Bonn

Abstract

Mosquito-borne diseases like the West Nile and Usutu viruses are becoming a growing threat to public health in Europe. These viruses are spreading more widely, and current treatments are limited. With climate change and increased mosquito populations, the risk of outbreaks is rising. There is an urgent need for effective solutions to prevent and treat these infections. With this in mind, the EU-funded REFINE project will develop treatments. It focuses on understanding how the viruses interact with the human body and identifying targets for drugs and vaccines. The project uses advanced models to test the safety of potential treatments. Ultimately, REFINE aims to improve Europe’s ability to respond quickly to these viral threats.

Funding programme
Horizon Europe

Coordinator
Erasmus Universitair Medish Centrum Rotterdam, Netherlands

Duration
01.01.2025 - 31.12.2028

SURE-AMR - "Strengthening Ukraine's Research Excellence in the field of antimicrobial resistance under a one health approach"

Partner

Dr. Chihan Papan
Institut für Hygiene & Public Health
Venusberg-Campus 1
53127 Bonn

Abstract

SURE-AMR aims to improve the R&I capacities of IMBG to strengthen its scientific reputation, attractiveness and networking channels, while promoting scientific excellence in the field of antimicrobial resistance (AMR) under an One Health Approach (OHA). It aims to raise the level of excellence of IMBG to EU standards and to raise its profile nationally and at EU level through a sustainable framework for scientific and institutional capacity building, international collaboration and stakeholder engagement. The project will strengthen R&I and knowledge transfer through the development of targeted R&I study cases, training for IMBG researchers and IMBG staff, increased collaboration between academia, health sector and stakeholders with a general sustainable framework for research, international networking and a specific international mobility programme. Strengthening the experience of IMBG research staff, including a new generation of young scientists, will be achieved through the cooperation with EU partners with established scientific excellence in the topics and proven experience in economic impact and awareness raising and integration into national policies. At the scientific level, it is expected to enlarge the community of competitive and renowned researchers at IMBG in AMR, stronger and better connected to a core of international and relevant R&I systems, supported by skilled R&I managers with their international networks. At the social level, it is expected to improve the public health and environmental quality of Ukraine (and EU) through an OHA, while developing broader social systems appropriate to the Ukrainian context to face better prevention, analysis and mitigation of AMR. At the economic level, the project will contribute to the development of innovative protocols, methodologies and innovative solutions for the health and ecological sector and the profitability of regional companies through new process improvements, innovation support and job creation.

Funding programme
Horizon Europe

Coordinator
Instytut Molekulyarnoi Biologii i Genetyky Nan Ukrainy

Duration
01.10.2024 - 30.09.2027

DeepHorizon - "DEploying Ecosystemic solutions to imProve soil Health and uncOveRing subsoil funtIons in the critical ZONe"

Partner
Prof. Dr. Wulf Amelung
INRES - Institut für Nutzpflanzenwissenschaften und Ressourcenschutz
Karlrobert-Kreiten-Strasse 13
53115 Bonn

Abstract

Life on Earth thrives on the foundation of healthy soils, including topsoil and subsoil. While extensive research has focused on the topsoil layer, the subsoils remain largely unexplored. By bringing together key experts and practitioners, DeepHorizon aims to unlock knowledge of the subsoil in critical zone in order to deploy ecosystemic solutions to improve subsoil functions for soil health. DeepHorizon goal is to develop tools that will enable practitioners, land managers and policy makers to access subsoil properties, subsoil functions, soil health indicators and financial decision support tools to promote sustainable subsoil management. Through a multi-actors approach from farmers to policy makers, DeepHorizon will (1) collect and use existing data on subsoils; (2) generate new knowledge through extensive subsoil sampling and experimental effort (40 core sites) to measure biological, physical and chemical properties of different subsoils with contrasted management, and different soil type (organic/mineral), land uses (forest, grassland, cropland and semi-natural areas) and climate ; (3) use innovative process-based models to quantify actual and potential subsoil functioning, and soil health indicators; and (4) involve practitioners and stakeholders in the project through living labs and partner networks to co-create, test and deploy innovative solutions to improve subsoil functions over 100 test sites across Europe. By creating its own community of end-users and key stakeholders, DeepHorizon will ultimately promote sustainable management practices, policy-incentives and guidelines at EU level for increasing carbon storage and ecosystem services in subsoils and disseminate and communicate materials to a better understanding of subsoil relevance to the general public. By improving knowledge and consideration of subsoils in general, DeepHorizon will enhance soil health and pave the way for a more sustainable and resilient environment in Europe.

Funding programme
Horizon Europe

Coordinator
Université Catholique de Louvain, Belgium

Duration
01.10.2024 - 30.09.2028

ERN PaedCan-Y7-Y10 - "European Reference Network on Paediatric Cancer"

Partner
Dr. med Gabriele Calaminus
Kinderklinik
Pädiatrische Hämatologie und Onkologie
Venusberg-Campus 1
53127 Bonn

Abstract

The goal of the European Reference Network for Paediatric Cancer (ERN-PAEDCAN) is to improve outcomes of childhood cancer by reducing the current inequalities in different member states.
ERN-PAEDCAN strives to reduce current inequalities in childhood cancer outcomes across Europe with a particular focus on widening countries and cross-border health care (CBHC) challenges. It addresses the current multi-fold obstacles and mobilises together with SIOPE, its European Clinical Trial Groups (ECTGs) and National Paediatric Oncology Societies and importantly with the childhood cancer advocates of CCI-E resources to enhance collaborative networks and to define adequate pathways for advice and CBHC care, hence fostering stronger cooperation between patients, professionals and healthcare authorities. Key objectives are harmonised guidelines already reflected in the recently created European Standard Front-line Treatment Guidelines that await a major implementation initiative together with the newly created ESCP registry in all countries currently unable to participate in respective complex randomised upfront trials for various reasons or where such trials are currently not open in certain indications. Given the need of modern diagnostics for adequate risk stratification in respective childhood cancers and often complex treatment situations requiring special skills and resources, ERN PaedCan reinforces pathways to satisfy these patient and family needs by providing not only information, but most importantly advise through virtual international tumour boards run with the key experts of the respective ECTGs already in the diagnostic period as well as at decision milestones during the treatment phase and at any later event. Easily accessible provision of education and training are further key actions.

Funding programme
EU4Health

Coordinator
St. Anna Kinderkrebsforschung GmbH

Duration
01.10.2023 - 30.09.2027

AI-POD - "Trustworthy AI Tools for the Prediction of Obesity Related Vascular Diseases"

Partner
Dr. Dmitrij Kravchenko
Department of Diagnostic and Interventional Radiology
Universitätsklinikum Bonn
Venusberg - Campus 1
53127 Bonn

Abstract

Weight problems and obesity are increasing at a rapid rate already concerning more than 436mio people in European countries. Obese persons have a 50% higher risk of cardio-vascular disease (CVD) mortality and treatment costs result in a total economic burden of over 210 billion Euro per year. To date the prediction of the individual risk for major adverse CVD events in the obese patient population is a challenge. Current risk scores are not sufficiently accurate and there is no implementation of scores into user friendly solutions. The AI-POD project aims to reduce the number of CVD related deaths in Europe by developing an AI-based risk prediction score to support clinical decision making and by equipping obese persons with trustworthy AI tools. AI tools will integrate clinical, laboratory and imaging data to translate disease risk into actionable health information to guide diagnostic steps and treatment recommendations. The tools will be validated in six clinical sites on CVD and serve as the basis for a lasting interdisciplinary platform for distributed learning in other vascular territories. AI-POD will push the boundaries of clinical insight in CVD in obese persons, including its treatment and risk management. AI-POD main outcomes are (1) a novel imaging-based AI-based risk score and Clinical Decision Support System (CDSS) for the risk assessment and prediction of obesity-related CVD and associated complications as a pre-requiste for further AIbased prevention and treatment management; (2) an innovative, easy-to-use mobile app for citizens (Citizen App) that interacts with the CDSS empowering obese people to better monitor and manage their own health. Physicians will benefit from more efficient workflows and in consequence, public health budgets will be unburdened by reducing morbidity and mortality of obese indiviudals.

Funding programme
Horizon Europe

Coordinator
Medizinische Universität Wien

Duration
01.05.2023 - 30.04.2027

Website

Changemaker - "Promoting co-designed sustainable health interventions with young changemakers for reduced risk of non-communicable diseases (NCDs) in urban Burkina Faso, Kenya and Tanzania"

Partner
Prof. Ina Danquah
Zentrum für Entwicklungsforschung (ZEF)
Genscherallee 3
53113 Bonn

Abstract

Changemaker objective: To implement & evaluate a sustainable health intervention program on health, nutrition, & environmental outcomes for the primary prevention of adolescent obesity & related non-communicable diseases (NCDs) together with adolescents in three rapidly urbanizing cities in Burkina Faso, Kenya, Tanzania. Background: There is an increasing epidemic of adolescent obesity that can contribute to adult obesity, morbidity & NCDs in a broader sense. Sustainable health interventions in urban low- and middle-income countries are critical in addressing lifestyle factors that contribute to obesity, diabetes & hypertension in later life, such as unhealthy dietary habits, inactivity & sedentary behaviors while shaping urban environments. Considering obesity is a complex issue that is influenced by wide range of interconnected factors, such as policy, environment, social, economic, cultural, behavioral, commercial, & biological determinants, a whole-systems approach that converges multiple sectors (i.e. health, education, environment, and agriculture) and stakeholders (i.e. adolescents, caregivers, staff, local government, communities, policymakers & implementers) are needed for obesity prevention in LMICs. Our strategy: Four evidence-based strategies, which will be adapted to context through a co-design process: 1) urban farming in schools with satellite farms and organic waste composting, 2) sustainable health modules for classrooms, 3) linking to healthcare workers through health talks using motivational interviewing techniques and 4) WHO Best Buys: Mass media campaign. Our evaluation: 3 cluster-RCTs in secondary schools, within the framework of urban Health & Demographic Surveillance Systems, implementation, process evaluation & cost-effective evaluation. Our expected results: Evidence of how to implement and scale a sustainable health intervention. Estimate a mean difference in BMI of 0.175 which could lead to reduction of 5% in the prevalence of obesity.

Funding programme
Horizon Europe

Coordinator
Karolinska Instiutet

Duration
01.01.2024 - 31.12.2027

CHANGER - "Challenges and Innovative Changes in Research Ethics Review"

Partner
Prof. Dr. Tade Spranger
Centre for Law of Life Sciences
Adenauerallee 24-42
53113 Bonn

Abstract

Trust in science and technology as well as the utility and acceptability of their innovative outcomes is crucially dependent on the ethical qualities of the research. This is the reason why research projects are submitted to an ethical review. Although the existing ethics review infrastructure includes experienced members with expertise in traditional research, this is not the case for new technologies and transformative research that result in new human rights, such as digital rights. Thus, there is a clear need for ethics committees to evolve in order to cover this gap and to be able to support innovation while embedding new human rights. CHANGER aims to promote changes in research ethics reviews that strengthen the capacities of researchers to incorporate ethical judgements in the project design and implementation, and to support ethics committees to address new challenges posed by new technologies and new research practices. CHANGER will review current practices and ethics criteria, will identify and discuss new challenges emerging from new technologies and from new research practices, which are not sufficiently covered in the current review process, will provide innovative training to ethics review experts and researchers, and propose innovative approaches and tools to ethics review reform and new understandings to practice ethics by design, supported by guidelines and a policy roadmap. The CHANGER interdisciplinary consortium has extensive and long-standing experience-based expertise in research ethics reviews, integrity oversight and human rights and is capable of providing novel solutions to the needs in ethics reviews.

Funding programme
Horizon Europe

Coordinator
National Center for Scientific Research "DEMOKRITOS"

Duration
01.01.2024 - 31.12.2026

AI4HOPE - "ARTIFICIAL INTELLIGENCE BASED HEALTH, OPTIMISM, PURPOSE; AND ENDURANCE IN PALLIATIVE CARE FOR DEMENTIA"

Partner
Prof. Dr. Lukas Radbruch
Klinik und Poliklinik für Palliativmedizin
Venusberg-Campus 1
53127 Bonn

Abstract

Dementia is caused by a range of illnesses and disorders that damage the brain either directly or indirectly. With the rise of the ageing population in the EU, dementia is becoming a serious problem. Digital health interventions have the potential to improve the accessibility and effectiveness of palliative care. Palliative care is an area where these technologies are increasingly being evaluated for education (e.g. online learning, mobile applications or Virtual Reality tools), symptom management, care planning, decision-making, and interaction (e.g. professionals and caregivers using phones, internet and computer systems). However, most studies focus on a specific intervention with heterogeneous outcomes and are exposed to professional gatekeeping and biased samples consisting of patients who are mostly well and without considering cultural impacts. Due to improved understanding and treatment, more effective and innovative health technologies, improved patient safety and better ability and preparedness to manage epidemic outbreaks, along with priorities related to quality of life of dementia patients and survivors, treatment and dementia data monitoring should be crucial. This project will focus on: i) better understanding of dementia, focusing on their consequences, including pain, distress and causative links between health determinants, disease and interventions in order to provide evidence-base for policy-making, ii) identification of holistic intervention (treatment and care) and assessment of health outcomes, iii) innovative digital tools to optimize clinical workflows and iv) scientific evidence for improved/tailored policies and legal frameworks and to inform major policy initiatives at EU and global level. We target exactly those aspects of value by integrating digital interventions as palliative care of patients with poor prognosis of dementia and evaluating the impact of digital health interventions using Artificial Intelligence.

Funding programme
Horizon Europe

Coordinator
University of Turku

Duration
01.01.2024 - 31.12.2027

VIRTUAL BRAIN TWIN - "Virtual Brain Twin for personalised treatment of Psychistric Disorders"

Partner
Prof. Dr. Christiane Woopen
Center for Life Ethics
Schaumburg-Lippe-Straße 7
53113 Bonn

Abstract

In the EU, about 165 million people are affected each year by mental disorders, and estimates indicate that mental disorders will become the number 1 economic cost factor in medicine in 2030. Schizophrenia alone affects approximately 1% of the world's population. The clinical effectiveness of the antipsychotics on the market remains limited with 30 to 50% of schizophrenic patients showing an insufficient response to treatment. Several factors, from genetic to psychological and social, may lie behind poor treatment outcomes or side effects and varies from patient to patient. Therefore, the central aim of the VIRTUAL BRAIN TWIN project is to create an ecosystem for generating virtual brain twins for psychiatric patients, by leveraging the consortium’s detailed knowledge and expertise in neuronal microcircuit simulation, mathematical analysis, innovative AI tools, and psychiatric care and clinical studies. This ecosystem will guide clinicians to optimise medication type and dosage, and to evaluate alternative treatments, such as brain stimulation and lifestyle changes. Multiscale cause-effect simulations and virtual brain simulations based on fMRI or sMRI data from the individual patient, will bridge the gap between molecules and the patient's brain. At the centre of this ecosystem will be the Virtual Brain Twin platform, which will make use of big data, multiscale modelling, and high-performance computing (HPC) that will be secured by appropriate data safety and protection. The platform will be embedded in the European digital neuroscience research infrastructure EBRAINS and will be initially accessible to neuroscientists, clinical researchers, and mathematical modellers, and in the future, to clinicians, and patients as well. This ground-breaking project will pave the way for personalised treatment of psychiatric disorders, with the potential to significantly improve the quality of life of patients suffering from these conditions.

Funding programme
Horizon Europe

Coordination
EBRAINS

Duration
01.01.2024 - 31.12.2027

BEATsep - "Biomarkers established to stratify sepsis long-term adverse effects to improve patients’ health and quality of life"

Partner
Prof. Dr. Bernardo Franklin
Institute of Innate Immunity
Venusberg-Campus 1
53127 Bonn

Abstract

Sepsis is a life-threatening organ dysfunction resulting from dysregulated immune responses to infection, affecting almost 50 million people yearly. Sepsis is a major global health challenge and a leading cause of death worldwide. Moreover, people surviving sepsis often suffer post-sepsis immunosuppression, a long-lasting state of immune dysfunction predisposing them to infections, autoimmune and non-communicable diseases (NCDs), and long-term reduced fitness. The molecular mechanisms driving post-sepsis immunosuppression remain largely elusive. Furthermore, predicting which patients will survive or develop immunosuppression is currently impossible. BEATsep will tackle this challenge by combining the expertise of physicians, clinician scientists and immunologists in top European institutions. We will, for the first time, longitudinally assess unique immunological and clinical parameters and combine them to: i) gain insight into the long-term immunological consequences of septic shock; ii) identify novel markers to identify patients at risk; and iii) unravel molecular mechanisms driving post-sepsis immunosuppression. We will also develop strategies to improve the stratification of acute sepsis survivors to identify patients with a higher risk of sepsis-associated NCDs and comorbidities. BEATsep will have significant societal, scientific, and economic impacts, as efficient prevention of sepsis-induced comorbidities could save significant amounts within healthcare budgets and potentially improve the quality of life for millions worldwide who suffer from the long-term effects of sepsis.

Funding programme
Horizon Europe

Coordination
FAKULTNI NEMOCNICE U SV. ANNY V BRNE

Duration
01.01.2024 - 31.12.2028

GEMINI - "A Generation of Multi-scale Twins of Ischaemic and Haemorrhagic Stroke Patients"

Partner
Prof. D. Matthias Braun
Evangelisch-Theologische Fakultät
Rabinstrasse 8
53111 Bonn

Abstract

GEMINI aims to deliver validated multi-organ and multi-scale computational models for treatment decision support and improved fundamental understanding of acute strokes, both ischaemic and haemorrhagic. We will demonstrate the added benefit of these computational models in personalised disease management. Specifically, GEMINI will deliver validated, integrated multi-scale, multi-organ Digital Twin in Healthcare (DTH) models for cerebral blood and cerebrospinal fluid flow, brain perfusion and metabolism, and blood flow and thrombosis along the heart-brain axis by integrating available and newly developed dynamic, interoperable, and modular computational models. Building on these models, GEMINI will deliver validated population-based DTHs of ischemic and haemorrhagic stroke aetiology and onset, treatment, and disease progression. Utilising these population-based DTHs, GEMINI will validate five personalised subject-specific DTHs, (1) stroke treatment, and (2) disease progression DTHs for acute ischaemic stroke and (3) aneurysm treatment, (4) subarachnoid haemorrhage progression, and (5) unruptured intracranial aneurysm risk assessment DTHs for haemorrhagic stroke to guide patient care and long-term management. We will bring proof of value of digital twins by the evaluation of the ischaemic stroke treatment selection DTH in a multi-centre clinical trial, in which treatment and patient outcomes are compared in situations with and without the availability of a DTH. GEMINI will implement a project-wide structured approach for data harmonisation, curation, model validation, verification, and model certification of the DTHs. Several outcomes of GEMINI have a high value for clinical practice, medical device industry, and in enhancing research in the fields of (bio)medical and computer sciences, warranting an extensive valorisation strategy with adequate IP protection and versatile exploitation actions to enhance a wide adaptation of the results of GEMINI.

Funding programme
Horizon Europe

Coordination
ACADEMISCH MEDICAL CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM

Duration
01.12.2023 - 30.11.2029

HealthyDiets4Africa - "Combating Malnutrition in Africa through Diversification of the Food System"

Partner
Prof. Ina Danquah
Center for Development Research (ZEF)
Genscherallee 3
53113 Bonn

Abstract

The more diverse the food system is, the easier it is to combat malnutrition and maintain biodiversity while reducing its environmental footprint. The EU-funded HealthyDiets4Africa project will focus on food security in Africa, which is struggling with various forms of malnutrition (hunger, micronutrient deficiencies and non-communicable diseases caused by unbalanced nutrition). The project is based on the central hypothesis that diversification of the food system helps to combat all forms of malnutrition while minimising its environmental footprint. Specifically, it will monitor dietary diversity in eight African countries representing different regions. Based on the findings, the project will design communication and policy strategies to maximise outreach and impact of diversified food systems.

Funding programme
Horizon Europe

Coordinator
Justus-Liebig-Universität Gießen

Duration
01.01.2023 - 31.12.2028

PHENET-EU - "Tools and methods for extended plant PHENotyping and Enviro Typing services of European Research Infrastructures"

Partner
Prof. Dr. Thomas Döring
Agrarökonomie und Organischer Landbau
Auf dem Hügel 6
53121 Bonn

Abstract

Europe urgently needs to find pathways towards agroecological transition of agroecosystems in support to food security, climate change resilience, biodiversity and soil carbon stocks restoration. In PHENET, the European Research Infrastructures (RI) on plant phenotyping (EMPHASIS), ecosystems experimentation (AnaEE), long-term observation (eLTER) and data management and
bioinformatics (ELIXIR) will join their forces to co-develop, with a diversity of innovative companies, new tools and methods - meant to contribute to new RI services - for the identification of future-proofed combinations of species, genotypes and management practices in front of the most likely climatic scenarios across Europe. Ambitioning to go beyond current highly instrumented but often spatially and temporally limited RI installations, PHENET derived services will allow wide access to enlarged sources of in-situ phenotypic and environmental data thanks to (i) new AI-based multi (agroecology-related) traits multi-sensors devices (ii) to unleashed access to high resolution Earth Observation data connected to ground based data, (iii) FAIR data support for connection with (iv) new generation of predictive modeling solutions encompassing AI and digital twins. Developments will be challenged by and implemented in a series of eight Use Cases covering a large range of agroecosystems but also of ecosystems to demonstrate portability of solutions. Several of these Use Cases will mobilize on-farm data. A large effort will be devoted to training RI staff and beyond through a sustained collection of training material fed by experts. Outreaching activities will aim at enlarging the range of RI users. PHENET will not only strengthen RI but will also have major impact on the development of innovative companies on phenotyping, envirotyping and precision agriculture as well as on the emergence of climate smart crop varieties and innovative practices fitted to climate change and agroecological transition.

Funding programme
Horizon Europe

Coordinator
Institut Nationale de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Duration
01.01.2023 - 31.12.2027

Website

TransformDairyNet - "Working together to upscale Cow-Calf-Contact dairy production and beyond"

Partner
Dr. Hugo Storm
Institut für Lebensmittel- und Ressourcenökonomik
Meckenheimer Allee 174
53115 Bonn

Abstract

A climate-smart approach to dairy farming that embraces cow-calf contact
Dairy farms traditionally separate calves from their mothers shortly after birth, but a new approach called cow-calf contact (CCC), allows them to remain together for months. This method not only promotes the health, growth, and well-being of the animals, but it also aligns with ethical and sustainable practices under the Green Deal initiative. The EU-funded TransformDairyNet project aims to advance climate-smart CCC dairy farming practices by identifying user needs, generating innovative ideas and solutions, and disseminating actionable knowledge. The project integrates scientific research with practical application, fostering farmer-led innovation, and enhancing the skills of European dairy farmers and advisors. Ultimately, it seeks to strengthen resilience, promote the adoption of climate-smart practices, and collaborate with dairy and climate-focused communities.

Funding programme
Horizon Europe

Coordinator
University Colege Dublin, Ireland

Duration
01.06.2024 - 31.05.2027

IntercropValuES - "Developing Intercropping for agrifood Value chains and Ecosystem Services delivery in Europe and Southern countries"

Partner
Dr. Sabine Seidel
Institut für Nutzpflanzenwissenschaften und Ressourcenschutz
Katzenburgweg 5
53115 Bonn

Abstract

IntercropValueES aims to exploit benefits of intercropping to design and manage productive, diversified, resilient, profitable, environmentally friendly cropping systems acceptable to farmers and actors in the agri-food chain. It will develop both a scientific research action for better understanding and modelling intimate intercrop functioning and a detailed analysis of lock-ins and levers at the value chain level to identify credible solutions that can be adopted by farmers and value chain actors. As a multi-disciplinary and multi-actor project, it brings together scientists and local actors representing food value chain. It includes 27 participants from 15 countries (3 continents) from a wide diversity of organizations and stakeholders. IntercropValuES organizes its activities in 6 objectives, to: 1) support the design of locally relevant, legitimate and innovative agri-food chains, through 13 Co-Innovation Case Studies; 2) understand the functioning and G*G*E*M interactions allowing the selection of compatible ideotypes and the optimization of machinery and management strategies for maximizing the productivity and delivery of ecosystem services with better soil health and mitigation of GHG (meta experiment 15 sites); 3) produce novel information, improved methods and tools for intercrop management and the assessment of their performance and profitability; 4) unravel intercropping performance by modelling; 5) analyze grain and sanitary quality of cereal-legume intercrops, functional qualities for food processing and new products, 6) uncover key barriers and levers at the value chain level to boost development, and identify new market avenues and solutions to increase economic added-value of intercrops. The Comms and Dissemination Plan is designed to diffuse outcomes widely by adapted channels to different end-users, such as farmers, advisors, food processing companies and machinery industries, retailers and citizens, academia, policymakers and influence bodies.

Funding programme
Horizon Europe

Coordinator
Centre de Cooperation Internationale en Recherche Agronomique pour le development - C.I.R.A.D EPIC

Duration
01.11.2022 - 31.10.2026

Website

REPRESSIT - "A novel class of clinical immune checkpoint inhibitors"

Partner
Prof. Dr. Felix Meißner
Institute of Innate Immunity
Universitätsklinikum Bonn
Vernusberg-Campus 1
53127 Bonn

Abstract

In the tumor microenvironment, continuous or “tonic” stimulation of T cells induces checkpoint signaling through inhibitory immune receptors (IRs). This phenomenon suppresses T cell function, contributing to an exhaustion phenotype and consequent failure to eliminate cancer cells. Checkpoint blockade through IR-targeting antibodies (e.g. anti-PD-1, anti-CTLA-4) can partially reverse this process, and has revolutionized cancer immunotherapy. However, as a large fraction of patients, e.g. with tumors that do not express IR ligands, do not benefit from this treatment. Thus, a large unmet need remains to be addressed. We aim to change the current ligand-centric “blockade” paradigm. The REPRESSIT platform technology developed herein will provide a radically new approach, through development of a novel class of ligand-independent checkpoint therapeutics. These Receptor Inhibition by Phosphatase Recruitment (RIPR) molecules recruit tyrosine phosphatases to the IR and shut down IR signaling, thereby reactivating exhausted T or NK cells to effectively clear cancer cells.

The REPRESSIT consortium unites unique complementary expertise and models in IR biology, tumor immunology, protein engineering, biophysics and proteomics, to: 1) define the design principles of RIPR molecules against multiple checkpoint IR targets, 2) evaluate the IR mode of action of signal inhibition, 3) optimize RIPR molecule for their efficacy using in vitro and in preclinical cancer models, and 4) demonstrate in vivo proof-of-concept (PoC)), focusing on highly relevant for a panel of T and NK cell IR known to display tonic signalling.

REPRESSIT will deliver a technology platform for off-the-shelf RIPR designs targeting phosphotyrosine-carrying IR. This project will provide the foundation for our long-term vision of innovative immune checkpoint therapeutics with unprecedented efficacy and provide a greatly improved perspective to the many cancer patients for which current treatment is ineffective.

Funding programme
Horizon Europe

Coordinator
Stichting Nederlandse Wetenschappelijk

Duration
01.05.2023 - 30.04.2028

environMENTAL - "Reducing the impact of major environmental challenges on mental health"

Partner
Prof. Dr. med. Markus M. Nöthen
Institut für Humangenetik
Universitätsklinikum Bonn
Venusberg-Campus 1
53127 Bonn

Abstract

The environMENTAL project will investigate how some of the greatest global environmental challenges, climate change, urbanisation, and psychosocial stress caused by the COVID-19-pandemic affect mental health over the lifespan. It will identify their underlying molecular mechanisms and develop preventions and early interventions. Leveraging cohort data of over 1.5 million European citizens and patients enriched with deep phenotyping data from large scale behavioural neuroimaging cohorts, we will identify brain mechanisms related to environmental adversity underlying symptoms of depression, anxiety, stress and substance abuse. By linking population and patient data via geo-location to spatiotemporal environmental data derived from remote sensing satellites, climate models, regional-socioeconomic data and digital health applications, our interdisciplinary team will develop a neurocognitive model of multimodal environmental signatures related to transdiagnostic symptom groups that are characterised by shared brain mechanisms. We will uncover the molecular basis underlying these mechanisms using multi-modal -omics analyses, brain organoids and virtual brain simulations, thus providing an integrated perspective for each individual across the lifespan and spectrum of functioning. The insight gained will be applied to developing risk biomarkers and stratification markers. We will then screen for pharmacological compounds targeting the molecular mechanisms discovered. We will also reduce symptom development and progression using virtual reality interventions based on the adverse environmental features - developed in close collaboration with stakeholders. Overall, this project will lead to objective biomarkers and evidence-based pharmacologic and VR-based interventions that will significantly prevent and improve outcomes of environmentally-related mental illnesses, and empower EU citizens to manage better their mental health and well-being.

Funding programme
Horizon Europe

Coordinator
Ksilink

Duration
01.06.2022 - 31.05.2027

REPO4EU - "Precision drug REPurpOsing For EUrope and the world"

Partner
Dr. med. Martin Coenen
Studienzentrum Bonn
Universitätsklinikum Bonn
Venusberg-Campus 1
53127 Bonn

Abstract

The Euro-Global Platform for Mechanism-based Drug Repurposing: From low precision drug therapy to high precision curative therapy through real-world data, Artificial Intelligence and a platform offering every step from lab to phase II clinical.

Funding programme
Horizon Europe

Coordinator
Universiteit Maastricht

Duration
01.09.2022 - 31.08.2029

Website

PAL-CYCLES - "PALliative Care Yields Cancer welLbEing Support"

Partner
Prof. Dr. med.Lukas Radbruch
Klinik und Poliklinik für Palliativmedizin
Universitätsklinikum Bonn
Venusberg-Campus 1
53127 Bonn

Abstract

Challenge: many patients with advanced cancer in the final phase of life leave the hospital without continuity of information, and certainty about further treatment and care provision. Often, communication between healthcare providers in different settings is suboptimal and this leads to poor continuity and coordination of care, negatively impacting the quality of life and increasing preventable hospital admissions. Solution: the PAL-CYCLES programme: a transitional palliative care programme for patients with advanced cancer, adaptable to local cultures and healthcare systems. The programme contains an intervention aiming for a smooth transition from hospital care to community care, consisting of five cornerstone components: (1) identification of a patient with palliative and supportive care needs in collaboration with the oncologist and the hospital palliative care team; (2) compassionate communication towards the patient and their family; (3) a collaborative multidimensional care plan and follow-up in the home care setting; (4) periodic evaluation of the care plan with patients and relatives; (5) identification of the terminal phase (if there) based on the periodic evaluations, with appropriate intensification of care and end-of-life talks depending on local possibilities and habits, including consultation with patient and families about ethically and legally sensitive issues. Plan: we intend to develop, adapt, implement, and evaluate the PAL-CYCLES programme in seven European countries using a stepped wedge randomized controlled trial design. Patient, relatives, and health care provider experiences, as well as ethical and equity issues will be addressed with qualitative methods. Impact: the PAL-CYCLES programme will facilitate patient-centred communication and continuity of palliative cancer care in the community care setting, reducing unplanned hospital admissions and improving quality of life for patients with advanced cancer at the end of life.

Funding programme
Horizon Europe

Coordinator
Stichting Radboud Universitair Medisch Centrum

Duration
01.09.2022 - 31.08.2027

BrightSpace - "Designing a Roadmap for Effective and Sustainable Strategies for Assessing and Addressing the Challenges of EU Agriculture to Navigate within a Safe and Just Operating Space"

Partner
Dr. agr. Hugo Storm
Institute for Food and Resource Economics
Nussallee 12
53115 Bonn

Abstract

The European Green Deal, aims, among others, to increase the contribution of EU agriculture to climate change action, improve the management of natural resources, ensure a fair economic return for farmers, and reinforce the protection of biodiversity. EU agriculture and food practices are currently not on the right track to meet the Green Deal ambitions and objectives. These objectives are interdependent, and while often aligned, they may also compete. Synergies and trade-offs between socio-economic and environmental outcomes are brought together in the concept of a Safe and Just Operating Space (SJOS), where the Safe component reflects the bio-physical boundaries of the ecosystem and the Just component the requirements for the well-being of the involved people. Policy makers and opinion leaders often lack sufficient information to gauge the likely effects of a SJOS crises in their country. The BrightSpace collaboration responds to this challenge by designing effective and sustainable strategies to navigate within a SJOS. BrightSpace provides an analytical toolbox to experiment, analyse, and coordinate the effects of innovative technologies, governance structures, as well as short- and long-term policies related to agriculture, thereby allowing for the execution of consistent, coherent, and lasting strategies with the desired consequences. The project emphasises the diversity of challenges regarding the SJOS across countries and regions and delivers new empirical evidence on cause-effect relations between drivers and outcomes relevant for the SJOS. A harmonised data framework and modelling toolbox are developed for medium-term and forward-looking projections of possible SJOS futures by 2050 and beyond. The support for effective and sustainable actions will include the identification of critical pathways for technological, institutional and consumer-oriented options for EU policies in the areas of agriculture, climate change, trade, and energy.

Funding programme
Horizon Europe

Coordinator
Stichting Wageningen Research

Duration
01.11.2022 - 31.10.2027

LAMASUS - "LAnd use and MAnagement modelling for SUStainable governance"

Partner
Dr. agr. Hugo Storm
Institute for Food and Resource Economics
Nussallee 12
53115 Bonn

Abstract

As part of the European Green Deal, the EU must achieve climate neutrality by 2050. The land use sector has a key role to play, which is recognized in the “Fit for 55 package”, where a climate neutrality target for the Agriculture, Forestry, and Other Land Use (AFOLU) is set for 2035. To enable fundamental transformations in the land use sector necessary to achieve the Green Deal, LAMASUS proposes a step change in land use sector governance from policy formulation to implementation to monitoring. LAMASUS builds on i) decades of experience in direct policy support, ii) unique modeling tools, such as GLOBIOM, the only model that integrates agricultural and land use sectors, and CAPRI, MAGNET and CLUE, which underlie JRC’s land use policy assessments, and iii) novel approaches mobilizing machine learning and citizen science. The project is driven by four key elements: EVIDENCE – dynamic monitoring of land use, management and related policies for evaluation and model calibration; UNDERSTANDING – state-of-the-art econometric and biophysical models to assess the role of past policies on changes in land use and management, and their economic and environmental impacts; TOOLS – a highly-integrated policy modeling framework with full sectorial coverage from agriculture and forestry to the whole economy, accounting for carbon, biodiversity and all relevant sustainability dimensions, at multiple scales (land use actors, country, EU level, global); GUIDANCE – a multi-level stakeholder dialogue for co-design of agriculture, forestry and climate policies by the EC, national and local governments and citizens, made accessible to stakeholders across multiple spatial scales through the novel web-based LAMASUS Portal. In this way, LAMUSUS will create a new level of societal engagement in which local actors contribute to the design of effective and efficient EU policies for climate neutrality and will serve as an exemplar for other policy processes within the European Green Deal.

Funding programme
Horizon Europe

Coordinator
International Institute for Applied Systems Analysis

Duration
01.09.2022 - 31.08.2026

UVQuanT - "Deep Ultraviolet Laser For Quantum Technology"

Partner
Prof. Dr. Simon Stellmer
Physikalisches Institut
Nussallee 12
53115 Bonn

Abstract

Lasers are the heart of today’s quantum science and technology. Since their first invention they have been a flourishing research area and in a few decades have found application in an enormous variety of fields, eventually populating many aspects of our everyday life, also outside of the research laboratory. Since the beginning, there has been a natural push towards extending the accessible frequency range of coherent radiation, eventually covering the whole infrared (IR), visible (VIS), and ultraviolet (UV) spectrum. The large energy and momenta of UV photons offers enormous potential for novel applications. However, for the same reason, deep technological challenges remain before they can be used effectively in science and technology. UVQuanT will tackle this challenge by developing the necessary industrial and scientific expertise to realise new-era, cost-effective lasers and laser optics for the UV and DUV region, positioning the EU as the front-runner in this technology. UVQuanT will focus on new ways of increasing the production of coherent radiation in the UV and DUV region, developing and testing lower cost, more rugged and practical solutions, and will test these novel systems in a range of experiments targeting quantum technology applications. Combining the talent and expertise of iindustrial and academic partners, UVQuanT will build strong relationships for establishing a path for next-generation quantum
technologies.

Funding programme
Horizon Europe

Coordinator
Fritz Haber Institute - Max-Planck-Gesellschaft

Duration
01.10.2022 - 30.09.2026

ReMade-at-ARI - "Recyclable Materials Development at Analytical Research Infrastructures"

Partner
Prof. Dr. Maximilian Mayer
Center for Advanced Security, Strategic and Integration Studies
Römerstraße 164
53117 Bonn

Abstract

A radical shift to the Circular Economy is urgently needed to cope with the challenge of finite resources decreasing at a frightening pace while the quantity of waste increases alarmingly. The European Commission?s (EC) Circular Economy Action Plan (CEAP) adopted in March 2020 has identified seven key product value chains that must rapidly become circular, given their environmental impacts and circularity potentials. This requires substantial research on materials with a very high recycling capability while exhibiting competitive functionalities. In ReMade@ARI, the most significant European analytical research infrastructures join forces to pioneer a
support hub for materials research facilitating a step change to the Circular Economy. ReMade@ARI offers coordinated access to more than 50 European analytical research infrastructures, comprising the majority of the facilities that constitute the Analytical Research Infrastructures in Europe (ARIE) network. ReMade@ARI offers comprehensive services suiting any research focusing on the development of new materials for the Circular Economy in the key areas highlighted in the CEAP and plays an important role in the preparation of the common technology roadmap for circular industries. Senior scientist, facility experts and highly trained young researchers contribute scientific knowledge and extensive support to realise a user service of unprecedented quality, making each promising idea a success. Particular attention is attributed to the implementation of attractive formats to support researchers and developers from industry. The comprehensive service catalogue is complemented by an extensive training programme. Communication and dissemination activities are underpinned by a continuous impact assessment, which also enables evidencebased decision-making in the context of the proposal selection. Routes to sustainability of the platform will be explored towards the end of the project.

Funding programme
Horizon Europe

Coordinator
Helmholtz-Zentrum Dresden-Rossendorf

Duration
01.09.2022 - 31.08.2026

SCREEN4CARE - "Shortening the path to rare disease diagnosis by using newborn genetic screening and digital technologies"

Partner
Prof. Dr. Janbernd Kirschner
Zentrum für Kinderheilkunde
Venusberg-Campus 1
53127 Bonn

Abstract

In the EU alone, roughly 30 million people are affected by one of the more than 6,000 different rare diseases (RDs) of which 72% are genetic and 70% affect children. The path to diagnosis for people suffering from a RD is burdensome, often severely delayed by a diagnostic odyssey. This unacceptable situation does not meet the concept of equity for EU citizens, and requires rapid, structured, and cost-effective corrective actions. The Screen4Care (S4C) consortium will leverage the genomic and digital advent to develop and pilot genetic NBS and AI-guided symptom recognition algorithms, while accounting for all relevant legal, regulatory and ethical considerations. S4C aims to harmonize the results of existing efforts in a horizon scan, by looking at the totality of the available data resources, diagnostic algorithms, and other initiatives with similar ultimate goals. S4C will also provide two digital diagnosis support systems for RD on the basis of features and symptom complexes.

Funding programme
Horizon 2020

Coordinator
University of Ferrara

Duration
01.10.2021 - 30.09.2026

Website

Marie-Curie

Find out more about Marie Curie collaborative projects such as Doctoral Networks (DN) and Research and Staff Exchange (SE), in which researchers from the University of Bonn are involved.

International Training Networks (ITN) at the University of Bonn

Tie2gether - Next-generation therapeutics for vascular diseases  

Partner
Prof. Dr. Radoslaw Nova
Institute of Structural Biology
Venusber-Campus 1
53127 Bonn

Abstract
TIE2gether is a multidisciplinary research and training network addressing major unmet needs in vascular medicine.

A wide range of vascular-related diseases—including chronic kidney disease, diabetic vasculopathy, sepsis, glaucoma and vascular malformations—affects millions and imposes a major societal and economic burden. Yet these conditions still lack effective, mechanism-based therapies. A unifying feature across these clinically distinct diseases is dysregulation of the TIE2 signalling cascade: hyperactivation drives vascular malformations while insufficient activity causes vascular leak, inflammation and organ dysfunction. Restoring balanced TIE2 signalling thus represents a major, largely unexplored therapeutic opportunity with relevance across both common and rare diseases.

TIE2gether translates this opportunity into real-world benefit by training a new generation of scientists capable of bridging fundamental discovery with therapeutic innovation. The network brings together leading experts in vascular biology, organ-on-chip technologies, advanced disease modelling, chemical biology, protein engineering, and drug discovery. By centring around a single, highly druggable pathway, TIE2gether creates strong synergy and accelerates the transfer of mechanistic insight into validated therapeutic strategies evaluated in human-relevant systems.

Fourteen Doctoral Candidates will gain cutting-edge competences in dissecting TIE2 signalling mechanisms, developing state-of-the-art disease models and designing and assessing next-generation therapeutics, including network-developed drug leads. Complemented by interdisciplinary, clinical and patient-facing training, they will acquire the innovation mindset, translational expertise and transferable skills needed across academia, industry and the biomedical sector. TIE2gether will deliver skilled researchers and novel therapeutic concepts to advance targeted treatments for vascular diseases with major societal impact.

Funding programme
Horizon Europe: MSCA -Docotral Network

Coordinator
HELSINGIN YLIOPISTO

Duration
01.02.2027 - 31.01.2031

REMOLD - "Representations, Motives and Langlands Duality"

Partner
Prof. Dr. Catharina Stroppel
Mathematisches Institut
Endenicher Allee 60
53113 Bonn

Abstract

Geometric representation theory, the Langlands program and motives
The field of mathematics often seems abstract to non-experts, yet it is the foundation for explaining many everyday physical, biological and chemical phenomena, and even many dynamic social and economic constructs. With the support of the Marie Skłodowska-Curie Actions programme, the REMOLD project will develop a network of doctoral candidates to investigate and advance important topics in representation theory, algebraic geometry and number theory. It will focus on geometric representation theory and the so-called Langlands program – also referred to as a ‘grand unified theory of mathematics’ – leveraging recent mathematical innovations from the field of motives. A leading European quantum computing company will participate in training the students.

Funding programme
Horizon Europe

Coordinator
Universita Degli Studi di Padova, Italien

Duration
01.01.2025 - 31.12.2028

MIRACLE - "Multilevel inflammatory regulation in cardiometabolic disease"

Partner
Dr. Thomas Ulas
LIMES-Institut
Carl-Troll-Str. 31
53115 Bonn

Abstract

The benefit of targeting inflammatory pathways in cardiometabolic disease on top of traditional healthcare and medication is evident from recent clinical studies. However, generalized blocking of inflammation also impacts on patients’ defense against infections and other immune-associated pathologies, such as cancer. Clearly, more precise interventions that target disease-specific cellular subsets and mechanisms are eagerly awaited. MIRACLE’s focus on innovation is to pave the way to precision medicine by deploying and valorizing current technological breakthroughs for a detailed definition and targeting of cardiometabolic disease-associated and causative cellular subsets. MIRACLE is inspired by latest advances in single cell biology, multi-omics analysis and newest insights in macrophage biology. These advances revealed heterogeneous and dynamic accumulation of (immune) cell populations in tissues that associate with disease initiation, development and particularly clinical outcome, a notion that has immense implications on our view of chronic inflammatory diseases and their treatment. Unique know-how is ready to be transferred to highly talented fellows. In MIRACLE, twelve young scientists will receive tailored training that enables them to study local and environmental factors that drive cardiometabolic inflammation as well as develop strategies to suppress them, via the integrated use of cutting-edge single cell, spatial mapping, computational and disease modeling approaches. Moreover, they will be able to develop and polish skills in translational science by working with biotech- and pharma experts and clinicians pledging clinically actionable outcomes. The combination of high-level science with top-notch infrastructures, resources, and solid data places MIRACLE at the forefront to move single cell biology towards cardiometabolic (precision) medicine and foster the scientists of tomorrow.

Funding programme
Horizon Europe

Coordinator
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM

Duration
01.02.2024 - 31.01.2028

Tools4Teams - "Research Training to Design and Implement Tools Supporting Safe Teamwork in Healthcare"

Partner
Prof. Dr. Matthias Weigl
Institut für Patientensicherheit (IfPS)
Universitätsklinikum Bonn
Venusberg-Campus 1
53127 Bonn

Abstract

The Tools4Teams research project aims to establish a doctoral training network under the MSCA-DN funding scheme. The network will prepare the next generation of teamwork experts to contribute new insights and smart technologies for safe and effective care. Tools4Teams brings together expertise from social and technical sciences, human-centered design, education, and clinical specialties. The research team will be cooperating with non-academic partners from industry, healthcare, and education to reach both scientific and societal impact. Tools4Teams recognizes and builds upon the transformative opportunities created by the application of behavioral sciences methodologies in healthcare and extends it with human- centered design of tools to target the most challenging problems in the delivery of safe and effective care. Mixed-methods designs will be applied to advance scientific knowledge and create evidence-based training and tools: to support team interaction processes; to integrate patient involvement in teamwork; to support the performance of multi-team systems; to facilitate innovative training applications (i.e. virtual and augmented reality). This research has practical implications for healthcare as a whole and will benefit clinical teams and the patients to whom they provide care.

Funding programme
Horizon Europe

Coordinator
Vanderbilt University Medical Center

Duration
01.03.2023 - 28.02.2027

HEPINIB - Heparanse inhibition as a multifunctional targeting approach in cancer

Partner
Prof. Dr. Gerd Bendas
Pharmazeutisches Institut
An der Immenburg 4
53121 Bonn

Abstract
A novel molecular target for cancer
Heparan sulfate (HS) is a carbohydrate of varied structure that attaches to proteins found on the cell surface and in the extracellular matrix. Emerging evidence indicates that this process is deregulated in cancer and affects cancer cell interactions with the tumour microenvironment and the immune system, promoting cancer progression and metastasis. Funded by the Marie Skłodowska-Curie Actions programme, the HEPINIB project proposes to use as a drug target the enzyme heparanase that cleaves HS and contributes to the remodelling of the extracellular matrix. The working hypothesis is that the therapeutic targeting of heparanase will work on many levels, impeding metastasis, angiogenesis and inflammation.

Funding programme
Horizon Europe: MSCA - Docotral Network

Coordinator
Universität Münster

Duration
01.01.2023 - 31.12.2026