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Christoph Heuser-Loy
© Universitätsklinikum Bonn
Dr. Christoph Heuser-Loy

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Zugehörigkeiten
  • Medical Clinic III - Hematology & Oncology
Forschungsschwerpunkte
  • T-cell biology
  • synthetic immunology
  • immunotherapy
Our research focuses on boosting the functional persistence of T cells to develop innovative adoptive cell therapies. By diving deep into the biology of functional, exhausted, and engineered CD8+ T cells, we uncover critical metabolic, genetic, and epigenetic switches that control their fate. Harnessing these master regulators, we re-engineer T cells and explore how they adapt and respond to different signals and environments, paving the way for more powerful and durable immunotherapies.
Ausgewählte Publikationen

Baldwin JG et al. (2024) Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy. Cell 187:6614-6630.e21.

Heuser-Loy C (2024) Interleukin-10 gives exhausted chimeric antigen receptor (CAR) T cells a second breath. Cancer Commun (Lond) 44:787–790.

Heuser C, Renner K, Kreutz M, Gattinoni L (2023) Targeting lactate metabolism for cancer immunotherapy - a matter of precision. Semin Cancer Biol 88:32–45.

Heuser C, Gotot J, Piotrowski EC, Philipp M-S, Courrèges CJF, Otte MS, Guo L, Schmid-Burgk JL, Hornung V, Heine A, Knolle PA, Garbi N, Serfling E, Evaristo C, Thaiss F, Kurts C (2017) Prolonged IKKβ Inhibition Improves Ongoing CTL Antitumor Responses by Incapacitating Regulatory T Cells. Cell Rep 21:578–586. 

Christoph Heuser-Loy
© Universitätsklinikum Bonn
Dr. Christoph Heuser-Loy

Webseite

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