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Dirk Baumjohann
© J. Saba
Prof. Dr. Dirk Baumjohann

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Zugehörigkeiten
  • Medizinische Klinik und Poliklinik III, Universitätsklinikum Bonn
Forschungsschwerpunkte
  • immunology
  • T-helper cells
  • autoimmunity
CD4-positive T helper cells orchestrate the cellular and humoral immune response to various pathogens, including viruses, bacteria, fungi, and parasites. T follicular helper (Tfh) cells provide help to B cells for efficient antibody production during infection or vaccination. However, dysregulated Tfh cells can also cause autoimmunity and allergies. Interestingly, depending on the context, Tfh cell frequencies have been correlated with either positive or negative outcomes of various tumor entities. Tfh cells have also emerged as central intermediaries of other T helper cell-mediated immune responses that involve the generation of certain effector and memory T helper cell populations, a topic that we are studying in the lab utilizing sophisticated in vivo models and various patient cohorts.
Ausgewählte Publikationen

Chang Y, Bach L, Hasiuk M, Wen L, Elmzzahi T, Tsui C, Gutiérrez-Melo N, Steffen T, Utzschneider DT, Raj T, Jost PJ, Heink S, Cheng J, Burton OT, Zeiträg J, Alterauge D, Dahlström F, Becker JC, Kastl M, Symeonidis K, van Uelft M, Becker M, Reschke S, Krebs S, Blum H, Abdullah Z, Paeschke K, Ohnmacht C, Neumann C, Liston A, Meissner F, Korn T, Hasenauer J, Heissmeyer V, Beyer M, Kallies A, Jeker LT, Baumjohann D (2024) TGF-β specifies TFH versus TH17 cell fates in murine CD4+ T cells through c-Maf. Sci Immunol 9(93):eadd4818

Gutiérrez-Melo N, Baumjohann D (2023) T follicular helper cells in cancer. Trends Cancer 9(4):309-325.

Huber JE, Ahlfeld J, Scheck MK, Zaucha M, Witter K, Lehmann L, Karimzadeh H, Pritsch M, Hoelscher M, von Sonnenburg F, Dick A, Barba-Spaeth G, Krug AB, Rothenfußer S, Baumjohann D (2020) Dynamic changes in circulating T follicular helper cell composition predict neutralising antibody responses after yellow fever vaccination. Clin Transl Immunology 9:e1129.

Schmidt A, Huber JE, Sercan Alp Ö, Gürkov R, Reichel CA, Herrmann M, Keppler OT, Leeuw T, Baumjohann D (2020) Human adenoid tissue-based ex vivo culture systems reveal anti-inflammatory drug effects on T and B cells. EBioMedicine 53:102684.

Dirk Baumjohann
© J. Saba
Prof. Dr. Dirk Baumjohann

Webseite

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