My group studies tissue adaptation and tissue specific functions of myeloid immune cells, in particular eosinophils. Tissue-resident eosinophils are present in many organs under homeostatic conditions and fulfil tissue-specific functions. We previously demonstrated that eosinophils undergo local tissue adaptation in the intestine. During this process, the eosinophil transcriptome is reprogrammed, changing eosinophil phenotype and function. Current questions include how this process of adaptation is regulated in other tissues and what the networks of transcription factors are that mediate the adaptation. We also study local tissue factors induce eosinophil reprogramming. Ultimately, eosinophils adaptation enables them to maintain healthy tissue functions and contribute to immune responses. By comparing homeostatic adaptation and mal-adaptation in the disease context, we aim to identify pathways involved in pathogenic eosinophil functions that may be targeted therapeutically.