Vernetzung in Europa

EU-Verbundprojekte der Universität Bonn

Zur Forschung an der Universität Bonn gehört die Kooperation mit exzellenten internationalen Partnern, weshalb die Beteiligung am EU-Forschungsrahmenprogramm Horizon Europe von großer Bedeutung ist.

Verbundprojekte (Koordination)

Sie finden hier eine Übersicht über die EU-Verbundprojekte, die von Wissenschaftler*innen der Universität Bonn koordiniert werden.

Macustar
© colourbox

EU-Verbundprojekte, die von der Universität Bonn koordiniert werden

Koordinatorin

Prof. Dr. Annette Scheersoi
Fachdidaktik Biologie
Meckenheimer Allee 170
53115 Bonn

Abstract

We are facing complex societal challenges, such as protecting the environment, promoting healthy living and fighting climate change. To address such challenges, citizens must be equipped with the ability to responsibly engage in scientific discussions and decisions. Traditional formal schooling has not been able to achieve this goal: There is a wide-spread lack of scientific knowledge at all level of society and students' interest in science tends to decline within school years. One reason is the decontextualised way in which science is taught. MULTIPLIERS aims to facilitate the transition of schools into innovative and open collectors of new ideas, practices, scientific approaches, able to offer to the communities in which they are embedded a space for open, inclusive and inquiry-based learning on science issues which have an impact on citizens' lives. This will be achieved by establishing multiplayers' partnerships (Open Science Communities, OSCs) involving schools, families, civil society organisations, informal education providers, policy-makers, the media and a vast range of science institutions in six EU countries, very different in terms of geographical and economic situation. OSCs will jointly select socio-scientific issues to be tackled and develop real-life projects to be implemented in schools involving more than 1500 students of all educational levels across six EU countries. Students will interact with a broad spectrum of science professionals and be involved in data collection and decision-making processes. Via open community events, they will then share and rethink their findings and experiences, liaising with families and society, acting as science multipliers. To ensure the results' transferability and uptake, final recommendations, guidelines, and learning materials will be published in an multilingual open webspace; OSCs will be maintained and enlarged after the end of the project to further pursue the MULTIPLIERS open schooling process.

Laufzeit

01.11.2021 - 31.10.2024

Koordinator

Prof. Dr. Frank G. Holz / Prof. Dr. Dr. Robert Finger
Universitäts-Augenklinik Bonn
Universitätsklinikum Bonn
Ernst-Abbe-Straße 2
53127 Bonn

Abstract

People with dry age-related macular degeneration (AMD) gradually lose their central vision, usually in both eyes. It is already a leading cause of blindness worldwide, and as the population ages, the number of cases is likely to rise. There is currently no effective treatment for dry AMD. One barrier to the development of new treatments is the lack of tests capable of determining the effectiveness of treatments under development. Put simply, current tests do not detect all of the sight problems experienced by people with earlier stages of the disease (e.g. intermediate AMD).
The goal of the MACUSTAR project is to develop and validate tests that are capable of accurately detecting subtle changes in the disease over time. The project will follow more than 700 AMD patients over 3 years through tests including state-of-the-art imaging techniques and vision testing, as well as patient-reported outcome measures that capture the impact of the disease on patients’ quality of life. The hope is that these methods will prove capable of detecting changes in the patients’ disease. The team also hopes to shed new light on visual impairment in intermediate AMD and its progression, as well as the risk factors that cause the disease to progress faster in some patients than others.
By developing and validating new methods to study disease progression in dry AMD, the overall goal of MACUSTAR is to help drug development and make clinical trials of potential treatments more efficient.

Laufzeit

01.09.2017 - 31.08.2022

Website1


Verbundprojekte (Partner)

Wissenschaftler*innen der Universität Bonn sind darüber hinaus in zahlreichen EU-Verbundprojekten als Partner beteiligt. Informieren Sie sich hier über die verschiedenen Projekte.

Immunosep-Logo
© immunosep

EU-Verbundprojekte, an denen die Universität Bonn als Partner beteiligt ist

Partner

Prof. Dr. Joachim L. Schultze
DZNE / LIMES-Institut der Universität Bonn
Gemeinsame epigenomische Plattform

Venusberg-Campus 1
Gebäude 99
53127 Bonn

Abstract

Sepsis, the body's extreme response to an existing infection, is a life-threatening medical emergency. Without urgent treatment, sepsis can rapidly lead to tissue damage, organ failure and death. Antibiotics and intensive care units have dramatically improved sepsis treatment, and there is hope that immunotherapy can further improve outcomes. The mission of the EU-funded ImmunoSep project is to design and complete a proof-of-concept clinical trial of personalised immunotherapy in sepsis, and develop a next-generation theranostics platform for future personalised immunotherapy trials in sepsis. Theranostics is a new approach that combines specific targeted therapy based on specific targeted diagnostics. The theranostics platform of the current project will be based on a multidimensional systems biology analysis of omics-based data sets, to identify clinically relevant biomarkers and therapeutic targets for precision medicine.

Koordinator 

Stichting Katholieke Universiteit

Laufzeit 

01.01.2020 - 31.12.2023

Website32

Partner

Prof. Dr. Wolfgang Britz
Institut für Lebensmittel- und Ressourcenökonomik
Nußallee 21
53115 Bonn

Abstract

Trade agreements often fall short of capturing the complexity of agri-food trade policies, mainly in the case of major structural changes. The EU-funded BATModel project aims to address this issue, advancing the assessment of agri-food trade policies. The project will provide a new modular generation of trade models to support the European Commission, policy makers and other stakeholders in their effort to better account for specific issues such as non-tariff measures, geographical indications, zero trade flows, quality differentiation and global value chains. The project will ensure that its solutions have a long-term and lasting impact.

Koordinator

Institut National De Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Laufzeit

01.09.2020 - 31.08.2024

Partnerin

Prof. Ute Vothknecht
Institut für zelluläre und molekulare Botanik
Kirschallee 1
53115 Bonn

Abstract

The potato is one of the most important food crops in the world. However, its vulnerability to environmental stresses raises major concerns about food security. While there is limited knowledge of combined stress-signalling pathways in model plants like Arabidopsis, we have no such knowledge in crops, due to their particular metabolic mechanisms. The EU-funded ADAPT project will study the dynamics of complex signalling and response mechanisms, to identify the molecular mechanisms of adaptation to combined stress in potato. The project will develop new strategies for increased productivity, stability and quality under multiple stress conditions. It will combine molecular biology, stress physiology, systems biology and analytics with engineering and molecular breeding, engaging user-driven agencies for testing and implementation of the project's results.

Koordinator

Universität Wien

Laufzeit

01.07.2020 - 30.06.2024

Website3

Partnerin

Dr. Hajira Jabeen
Institut für Informatik
Endenicher Allee 19a
53115 Bonn

Abstract

The digitalisation of the energy sector enables higher levels of operational excellence with the adoption of disrupting technologies. The EU-funded PLATOON project offers methodology that deploys distributed/edge processing and data analytics technologies for optimised real-time energy system management in a simple way for energy domain experts. The project aims to develop and use the PLATOON reference architecture to build and deploy scalable and replicable energy management solutions that contribute to increased renewable energy consumption, smart grids management, increased energy efficiency and optimised energy asset management.

Koordinator

ENGIE

Laufzeit

01.01.2020 - 31.12.2022

Website 

Partner

Prof. Dr. Joachim L. Schultze
DZNE / LIMES-Institut der Universität Bonn
Gemeinsame epigenomische Plattform

Venusberg-Campus 1
Gebäude 99
53127 Bonn

Abstract

The goal of the EU-funded discovAIR project is to produce the first draft of the Human Lung Cell Atlas platform as a part of the Human Cell Atlas infrastructure. The development of novel therapeutic interventions is hampered by a limited understanding of lung cellular complexity: it is therefore vital to acquire detailed knowledge of lung cells, their interactions, and their organisation into macroscopic tissue architecture, in health and disease. To identify the molecular phenotypes of cells in disease, discovAIR will include lung tissues from patients in the molecular profiling and spatial mapping effort, and will chart cell state transitions from health to disease in the lung cell perturbation map. Project results will be shared with the scientific community and pharmaceutical industry through an open-access data visualisation and exploration platform.

Koordinator

Academisch Ziekenhuis Groningen

Laufzeit

01.01.2020 - 31.12.2021

Website

Partner

Prof. Dr. Simon Stellmer
Physikalisches Institut 
Nussallee 12
53115 Bonn

Abstract

Building on several joint European efforts and its direct precursor, CLONETS, the EU-funded CLONETS-DS project will design a sustainable, pan-European, ultra-precise time-and-frequency reference system available to the European research community. Specifically, this system will be able to transmit ultra-precise time and frequency information via optical fibres. The project will define the architecture, design the engineering model and strategies, outline roadmaps and elaborate on plans for the integration of the necessary environment into the European landscape. The project’s success will elevate Europe’s research community into a leading position to meet the needs created by technological developments such as cloud computing, the Internet of Things and Industry 4.0.

Koordinator

Geant Vereniging

Laufzeit

01.10.2020 - 30.09.2022

Website6

Partner

Prof. Dr. Franz Josef Hormes
Physikalisches Institut 
Nussallee 12
53115 Bonn

Abstract

SOLARIS is the first synchrotron built in Poland, under the auspices of the Jagiellonian University. The EU-funded Sylinda project will boost the research capacity of SOLARIS. The synchrotron radiation facility will thus be able to upgrade its X-ray absorption spectrometer. This could result in more effective collaborations with industrial partners in the pharmaceutical, biology, chemical and cosmetics sectors. The staff will be reinforced with an industrial liaison officer, a beamline scientist and a grant officer. Special focus will be placed on improving project management, proposal preparation and administration skills. Furthermore, the project will organise a summer school on science management for early-stage researchers. Their active participation in industrial research projects will broaden their views regarding industry innovation and funding opportunities.

Koordinator

Uniwersytet Jagiellonski

Laufzeit

01.01.2021 - 31.12.2023

Partner

Prof. Dr. med. Eicke Latz
Institut für Angeborene Immunität
Sigmund-Freud-Str. 25
53127 Bonn

Abstract

Depression is highly associated with cardiovascular disease (CVD), significantly increasing the risk of CVD development, acute events and mortality, especially in women. As a consequence, it represents a social and economic issue affecting the patient’s life and causing healthcare costs to rise. However, the mechanisms and progression of the disease remain unknown. The EU-funded TO_AITION project works on the hypothesis that immune-metabolic dysregulation due to genetic, lifestyle and environmental risk factors affects immunity mechanisms leading to CVD-associated depression. The project will effectuate basic, preclinical and clinical research applying data-driven strategies to detect and describe immune-metabolic mechanisms responsible for CVD-depression comorbidity, aiming to improve diagnosis and management of the disease.

Koordinator

Idryma Iatroviologikon Ereunon Akademias Athinon

Laufzeit

01.01.2020 - 31.12.2024

Website7

Partner

Prof. Dr. Bernd Weber
Center for Economics and Neuroscience
Nachtigallenweg 86
53127 Bonn

Abstract

Children are attracted to digital technology, but it is not yet clear how digitally mature they are. How is children's behaviour affected by ICT and to what extent? The EU-funded DIGYMATEX project intends to offer evidence-based instruments that can support understanding and estimating ICT effects on children's conduct. The first instrument consists of an advanced and ready for the market Digital Youth Maturity Index (DYMI), a cloud-based open-access instrument. DYMI will contribute in the development of an inclusive taxonomy that will inform stakeholders on the long-term impact of ICT on children and young people's behaviour. The second tool consists of a solution based on the development of the DiGYou programme. Both tools will contribute to a safer and profitable use of ICT.

Koordinator

Aarhus Universitet 

Laufzeit

01.02.2020 - 31.07.2024

Website8

 

Partner

Prof. Dr. Oliver Brüstle
Life & Brain Center
Venusberg-Campus 1
Gebäude 76
53127 Bonn

Abstract

Science has made tremendous progress in understanding the neuronal circuitry of the brain in both health and disease, as well as in terms of its structure and function. Our knowledge of local and distant brain circuitry seen in neurodegenerative diseases, combined with the potential of human embryonic stem cells for cell and tissue regeneration, can advance the treatment of debilitating diseases like Parkinson's and Huntington's. The EU-funded NSC-Reconstruct project is pushing the frontiers in research on stem cells for single cell types. In an ambitious effort, the team plans to reconstruct local networks through the incorporation of numerous cell types, and to restore complex networks and cortical projections, for truly functional and effective repair in complicated conditions like neurodegenerative diseases and stroke.

Koordinator

Universita Degli Studi Di Milano

Laufzeit

01.01.2020 - 31.12.2023

Website

Partner

Prof. Dr. Thomas Heckelei
Institut für Lebensmittel- und Ressourcenökonomik
Nußallee 21
53115 Bonn

Abstract

The European Union’s future Common Agricultural Policy (CAP) plays a pivotal role in developing a sustainable agricultural sector. The future CAP will be more flexible and adaptable to the needs of EU Member States and the individual decision making (IDM) units in the sector. To achieve this Member States develop strategic plans for the CAP that should define measurable objectives and means to achieve them. The EU-funded MIND STEP project will make use of agricultural and biophysical data and include individual decision making (IDM) unity in new and existing policy models for impact assessments. Using agricultural statistics and big datasets, the new IDM models will be estimated and calibrated, drawing on established economic and evolving machine learning techniques.

Koordinator

Stichting Wageningen Research

Laufzeit

01.09.2019 - 31.08.2023

Website

Partner

Prof. Dr. Christian Borgemeister
Zentrum für Entwicklungsforschung
Genscherallee 3
53113 Bonn

Abstract

The general objective of LEAP4FNSSA is to establish a sustainable structure, or ‘Platform’, for the efficient and coherent implementation of the AU-EU Research and Innovation Partnership as described in the FNSSA Roadmap. Under the aegis of the HLPD and its Bureau, and by building upon related projects such as RINEA, CAAST-Net.
Plus, ProIntensAfrica and LEAP-Agri, LEAP4FNSSA aims to achieve this overall objective through three specific objectives: - Increase the synergies and coherence between actors, research and innovation projects, initiatives and programmes, through the development of institutional alliances and clusters of projects; - Develop a learning environment and a large knowledge base, including monitoring and evaluation activities, creating communication and links between different initiatives to improve STI cooperation; - Establish a long term and sustainable governance and funding mechanism for the Platform. To reach these objectives, LEAP4FNSSA will build on a large consortium of experienced partners and implement a methodology based on 3 principles: long-term impact, relevance of the outputs to the HLPD, and innovative actions. Long-term impact of the CSA relates to its main objective to enable and catalyse the transformation of the existing AU EU FNSSA Partnership into a bi-continental Platform for collaboration, organised along a Knowledge and Management Communication Framework. Outputs relevant to the HLPD will be achieved by connecting and framing activities of all Work Packages on top of the supporting activities specifically requested in the SFS-33-2018. Innovative actions are foreseen to run the Platform efficiently throught e.g. the development of a new approach to information mapping, text and data mining, and testing of multistakeholder alliances at a regional level and the mobilisation of actors to manage research and innovation programming in a 4-steps management cycle.

Koordinator

Centre De Cooperation Internationale En Recherche Agronomique Pour Ledeveloppement - C.I.R.A.D. Epic

Laufzeit

01.11.2018 - 31.10.2022

Website

Partner

Dr. Daniel Neuhoff
Institut für Organischen Landbau
Katzenburgweg 3
D-53115 Bonn

Abstract

"As the world population is continuously increasing, the supply of food with equal accessibility has become a major issue and future challenge. Microbes are unexploited tool to increase food productivity and quality. The objective of SIMBA project is to harness complex soil and marine microbial communities (microbiomes) for the sustainable production of food. SIMBA will focus on two interconnected food chains, i.e. crop production, aquaculture. SIMBA will first launch an in silico phase in order to analyze the further pre-existing microbiome databases and earlier studies, to identify the best microbiome layout capable of supporting food chain quality and productivity. Microbiome-tailored interventions will be specifically developed including soil, plant, fish, aquaculture and food/feed processing towards optimal layout as defined in the modelling step, as follows: i) Identified optimal microbiome consortia will be designed and tested in lab, pot and field trials to improve plant productivity and health; ii) Marine microbiomes will be applied to facilitate sustainable aqua and agriculture; iii) Optimal microbe/microbe consortia will be used to convert raw-materials and residuals to high quality food, feed or finally to energy. In a final intervention step, these interactions will be monitored and tested in field, aqua-culturing, fish feeding and human studies, measuring the impact on microbiome consortia, interactions in association with factors evaluating their efficacy in terms of improving food security, productivity, quality, safety, sustainability, nutritional and health aspects. ""Near to market” microbiome applications for sustainable food systems will be provided thanks to the interdisciplinary and cross-sectional nature of the proposal and the active role of small and medium sized enterprises (SMEs)."

Koordinator

Luonnonvarakeskus

Laufzeit

01.11.2018 - 31.10.2022

Website

Partner

Prof. Dr. Martin Weitz
Institut für Angewandte Physik
Wegelerstr. 8
53115 Bonn

Abstract

Quantum simulation is an emerging and exciting field for which several systems, such as ultracold-atoms, trapped ions or superconducting circuits are being actively investigated. In this project we aim to develop a novel platform for quantum simulation, based on photonic quantum fluids. Quantum fluids of light can be realised in different photonic systems with suitable nonlinearities, allowing to engineer an effective photon-photon interaction. The photon-photon interaction necessary to form a superfluid is provided by the optical nonlinearity of the medium. We will first fully characterize the superfluid and quantum turbulent regimes for quantum fluids of light, investigating the propagation in optically controlled landscapes with the demonstration of important milestones such as many-body localization and the superfluid to Mott–insulator transition. Based on these achievements and on the unprecedented flexibility offered by the all- optical control in quantum fluids of light, we will implement quantum simulations and simulate systems of very different nature, ranging from astrophysics to condensed matter. Fundamental open questions such as superconductivity, black hole physics, and quantum gravity will be addressed within the photon fluid platform.

Koordinator

Sorbonne Universite

Laufzeit

01.10.2018 - 30.09.2021

Website

Partner

Prof. Dr. Hartmut Schmieden
Physikalisches Institut
Nussallee 12
53115 Bonn

Abstract

In particle physics, a fundamental mechanism called strong interaction is responsible for strong nuclear force. This is the base of the Standard Model theory. Researchers are seeking to better understand and explain basic topics in this extremely promising field. They do this by conducting experimental and theoretical studies, mainly through particle collisions at low and high energies and calculations. Developments in state-of-the-art detectors are among their goals. The EU-funded STRONG-2020 project supports a close collaboration in a consortium involving 44 groups, 14 EU Member States, CERN and other institutions from numerous countries. It will create new possibilities, both in science and in applied research, for advanced medical and technological applications.

Koordinator

Centre National De La Recherche Scientifique CNRS

Laufzeit

01.06.2019 - 31.05.2023

Website

Partner

Prof. Dr. Michael Meier
Institut für Informatik 4
Friedrich-Hirzebruch-Allee 8
53115 Bonn

Abstract

In the domain of Cybersecurity Research and innovation, European scientists hold pioneering positions in fields such as cryptography, formal methods, or secure components. Yet this excellence on focused domains does not translate into larger-scale, system-level advantages. Too often, scattered and small teams fall short of critical mass capabilities, despite demonstrating world-class talent and results. Europe’s strength is in its diversity, but that strength is only materialised if we cooperate, combine, and develop common lines of research. Given today’s societal challenges, this has become more than an advantage – an urgent necessity. Various approaches are being developed to enhance collaboration at many levels. Europe’s framework programs have sprung projects in cybersecurity over the past thirty years, encouraging international cooperation and funding support actions. More recently, the Cybersecurity PPP has brought together public institutions and industrial actors around common roadmaps and projects. While encouraging, these efforts have highlighted the need to break the mould, to step up investments and intensify coordination. The SPARTA proposal brings together a unique set of actors at the intersection of scientific excellence, technological innovation, and societal sciences in cybersecurity. Strongly guided by concrete and risky challenges, it will setup unique collaboration means, leading the way in building transformative capabilities and forming world-leading expertise centres. Through innovative governance, ambitious demonstration cases, and active community engagement, SPARTA aims at re-thinking the way cybersecurity research is performed in Europe across domains and expertise, from foundations to applications, in academia and industry.

Koordinator

Commissariat A L Energie Atomique Et Aux Energies Alternatives

Laufzeit

01.02.2019 - 31.01.2021

Website

Partner

Dr. Kenneth M. Pfarr
Institut für Medizinische Mikrobiologie,
Immunologie und Parasitologie (IMMIP)
Venusberg - Campus 1
Gebäude 63
52127 Bonn

Abstract

Parasitic worms (helminths) are the most common sources of infection in developing countries and represent a greater global disease burden than malaria and tuberculosis. Soil-transmitted helminth infections affect nearly a fourth of the world's population, compromising nutritional status and cognitive processes. Onchocerciasis, also called river blindness, is transmitted by blackflies and causes terrible itching, eye lesions, and often blindness. Thanks to the EU-funded project HELP, an academic and industry collaboration, vaccines for these two infections may be on the horizon. Promising compounds will be fully evaluated in laboratory and clinical trials and this drug pipeline partnership could also streamline vaccine development for numerous neglected diseases.

Koordinator

Schweizerisches Tropen- und Public Health-Institut

Laufzeit

01.09.2019 - 31.08.2024

Website16

Partner

Prof. Dr. med. Lukas Radbruch
Klinik für Palliativmedizin
Venusberg-Campus 1
53127 Bonn

Abstract

The EU-funded PalliativeSedation project is investigating how to better help patients with refractory symptoms near the end of life. It focuses on the clinical, ethical, legal and moral aspects of providing deep sedation to dying patients across Europe. The project will review state-of-the-art refractory symptom management on a national level and current practices and guidelines in five international palliative care centres. Qualitative studies should enrich understanding of palliative sedation practices from the perspective of physicians, nurses and bereaved family members. The project will also conduct a moral case deliberation in 16 clinical centres across Europe to investigate clinical decision making regarding refractory symptoms and proportional palliative sedation. An online course should help clinicians, patients and families to better understand palliative sedation use for refractory symptoms.

Koordinator

Stichting Katholieke Universiteit

Laufzeit

01.01.2019 - 31.12.2023

Partner

Dr. Wolfgang Britz
Institut für Lebensmittel- und Ressourcenökonomik
Nussallee 19
53115 Bonn

Abstract

Ecological approaches to farming practices are gaining interest across Europe. As this interest grows there is a pressing need to assess the potential contributions these practices may make, the contexts in which they function and their attractiveness to farmers as potential adopters. In particular, ecological agriculture must be assessed against the aim of promoting the improved performance and sustainability of farms, rural environment, rural societies and economies, together.
The overall goal of LIFT is to identify the potentiel benefits of the adoption of ecological farming in the European Union (EU) and to understand how socio-economic and policy factors impact the adoption, performance and sustainability of ecological farming at various scales, from the level of the single farm to that of a territory.
To meet this goal, LIFT will assess the determinants of adoption of ecological approaches, and evaluate the performance and overall sustainability of these approaches in comparison to more conventional agriculture across a range of farm systems and geographic scales. LIFT will also develop new private arrangements and policy instruments that could improve the adoption and subsequent performance and sustainability of the rural nexus. For this, LIFT will suggest an innovative framework for multi-scale sustainability assessment aimed at identifying critical paths toward the adoption of ecological approaches to enhance public goods and ecosystem services delivery. This will be achieved through the integration of transdisciplinary scientific knowledge and stakeholder expertise to co-develop innovative decision-support tools.
The project will inform and support EU priorities relating to agriculture and the environment in order to promote the performance and sustainability of the combined rural system. At least 30 case studies will be performed in order to reflect the enormous variety in the socio-economic and bio-physical conditions for agriculture across the EU.

Koordinator

Institut National De Recherche Pour L'agriculture, L'alimentation Et L'environnement

Laufzeit

01.05.2018 - 30.04.2022

Website

Partner

Dr. Tim Schrabback
Argelander-Institut für Astronomie
Auf dem Hügel 71
53121 Bonn

Abstract

Our understanding of cosmology and fundamental physics continues to be challenged by ever more precise experiments. The resulting “standard” model of cosmology describes the data well, but is unable to explain the origin of the main constituents of our Universe, namely dark matter and dark energy. More than an order of magnitude improvement in the quality and quantity of observational data is needed. This has motivated ESA to select Euclid as the second mission of its cosmic vision program, with a scheduled launch in 2020. It is designed to accurately measure the alignments of distant galaxies due to the differential deflection of light-rays by intervening structures, a phenomenon called gravitational lensing. Euclid will measure this signal by imaging 1.5 billion galaxies with a resolution similar to that of the Hubble Space Telescope.
Although Euclid is designed to minimize observational systematics the observations are still compromised by two factors. Various instrumental effects need to be corrected for, and the tremendous improvement in precision has to be matched with comparable advances in the modelling of astrophysical effects that affect the signal. The objective of this proposal is to make significant progress on both fronts. To do so, we will (i) quantify the morphology of galaxies using archival HST observations; (ii) carry out a unique narrow-band photometric redshift survey to obtain state-of-the-art constraints on the intrinsic alignments of galaxies that arise due to tidal interactions, and would otherwise contaminate the cosmological signal; (iii) integrate these results into the end-to-end simulation pipeline; (iv) perform a spectroscopic redshift survey to calibrate the photometric redshift technique. The Euclid Consortium has identified these as critical issues, which need to be addressed before launch, in order to maximise the science return of this exciting mission, and enable the dark energy science objectives of Europe.

Koordinator

University College London

Laufzeit

01.04.2018 - 31.03.2022

Partner

Prof. Dr. Rainer Stamminger
Institut für Landtechnik
Nussallee 5
53115 Bonn

Abstract

"ANTICSS objectives are (i) to assess and define ""circumvention"" in order to achieve a better product positioning in relation to EU Ecodesign and Energy labelling legislation and relevant harmonised standards; this includes clear delimitation from other effects to facilitate unambiguous public (media) communication; (ii) to collect, analyse and learn from cases of circum¬vention by literature research and dedicated expert interviews, as well as analysing existing EU Ecodesign and Energy labelling legislation and standardisation for possible loopholes. The potential relation between circumvention and ""smart"" products with specific embedded software will be also addressed. From these findings, conclusions how to better detecting and preventing future circumvention will be derived; (iii) to assess impacts 'if' and 'how much' energy consumption and/or functional performance modifications could be ascribed to circumvention by conducting appliance testing; (iv) to define alternative test procedures or check lists with the aim to by-pass any possible measurement circumvention; based on the results ANTICSS will ensure sustainability beyond the project life by (v) practical capacity building measures for key actors of market surveillance and test laboratories, (vi) supporting communication and collaboration platforms between major stakeholders and (vii) providing policy recommendations for policy makers and standardisation bodies to prevent future circumvention under EU Ecodesign and Energy labelling. ANTICSS will also provide reliability to manufacturers by specifying potentially vague legislation and standards which might be interpreted differently by market actors and some of them taking unfair advantages so far. By overall awareness raising on circumvention among stakeholders, ANTICSS will be supporting an effective EU legislation enforcement and thus increasing acceptance and trust of market actors and civil society into the Ecodesign and Energy labelling legislation."

Koordinator

Öko-Institut e.V. - Institut für Angewandte Ökologie

Laufzeit

01.04.2018 - 30.09.2021

Website

Partner

Prof. Dr. med. Stefan Aretz
Institut für Humangenetik
Biomedizinisches Zentrum
Venusberg-Campus 1
Gebäude 13
53127 Bonn

Abstract

The main ambitions of the Solve-RD proposal are (i) to solve large numbers of RD, for which a molecular cause is not known yet, by sophisticated combined Omics approaches, and (ii) to improve diagnostics of RD patients through a “genetic knowledge web”. Solve-RD will pursue a clear visionary and integrated “beyond the exome” approach. The entire Solve-RD proposal has been motivated, designed and put together by a core group of four ERNs, but also reaches out to all 24 ERNs. To tackle diseases which are unsolved by applying cutting edge strategies, Solve-RD has thus formed a consortium that comprises (i) leading clinicians, geneticists and translational researchers of these ERNs, (ii) RD research and diagnostic infrastructures, (iii) patient organisations, as well as (iv) leading experts in the field of -omics technologies, bioinformatics and knowledge management. Solve-RD will deliver 7 main implementation steps: (i) Collect Phenotypes, (ii) New phenotype patterns, (iii) Re-analyse exomes / genomes, (iv) Novel molecular strategies, (v) Functional analysis, (iv) Clinical utility and (vii) Towards therapy. For analysis Solve-RD will apply data driven and expert driven approaches. We anticipate to increase diagnostic yield from 19.000 unsolved exomes/genomes by about 3-5%. Cohort specific innovative -omis strategies will be pursued, also addressing cost-effective issues. Analysis of more than 800 patients with highly peculiar (ultra-rare) phenotypes will highly increase the chance to find novel disease genes and novel disease mechanisms. We anticipate to solve more than 2.000 cases. Finding further matching patients will be secured by newly developed matchmaking approaches and by screening using MIPs technology in the more than 20.000 unclassified patients of the ERNs. For the first time in Europe we will also implement a novel brokerage structure connecting clinicians, gene discoverer and basic researcher to quickly verify novel genes and disease mechanisms.

Koordinator

Eberhard Karls Universität Tübingen

Laufzeit

01.01.2018 - 31.12.2022

Website

Partner

Dr. Hannah Jaenicke
INRES-Gartenbauwissenschaften
Auf dem Hügel 6
53121 Bonn

Abstract

Tomato is a main EU agricultural commodity, cultivated all over Europe in open and protected field and in glasshouses, representing a biological and agronomical model crop. Combined water and nutrient stress is a major problem for tomato farmers and solutions are needed to safeguard yields, while preserving the environment.
TOMRES will select, among over 10,000 available accessions, rootstocks and scions tolerating combined stress, while retaining fruit quality and yield, taking advantage of innovative screening approaches. Novel traits, in particular belowground, to be exploited in breeding, will be identified. The role of selected hormones (strigolactones and brassinosteroids) will be studied to identify further resilience traits.
TOMRES will test and optimize sustainable crop management strategies such as legume intercropping, precision fertilization and irrigation techniques, manipulation of symbiotic microorganisms, and the use of rootstocks more suited to water and nutrient uptake from the soil.
Novel genotypes X management strategies will be developed with the goal of reducing N and P application by at least 20%, water input by 40%, while granting environmental sustainability and economic viability of the solutions proposed.
Testing will be integrated with analysis of environmental (greenhouse emissions, water quality), and of socio-economic impact. Agronomical, environmental, and economical data will be processed to construction of models and of a Decision Support System.
Demonstration and dissemination activities will follow the whole course of the project, and will transfer the results to different environments and other cropping systems, thus ensuring the widest impact of the gained knowledge on the EU economy. Trans-disciplinary knowledge transfer among farmers, breeders, industries, associations and scientists will be granted by a solid multi-actor approach since the planning stage.

Koordinator

Universita Degli Studi Di Torino

Laufzeit

01.06.2017 - 31.05.2021

Website

Partner

Prof. Dr. Joachim L. Schultze
DZNE / LIMES-Institut der Universität Bonn
Gemeinsame epigenomische Plattform
Venusberg-Campus 1
Gebäude 99
53127 Bonn

Abstract

"The SYSCID consortium aims to develop a systems medicine approach for disease prediction in CID. We will focus on three major CID indications with distinct characteristics, yet a large overlap of their molecular risk map: inflammatory bowel disease, systemic lupus erythematodes and rheumatoid arthritis. We have joined 15 partners from major cohorts and initiatives in Europe (e.g.IHEC, ICGC, TwinsUK and Meta-HIT) to investigate human data sets on three major levels of resolution: whole blood signatures, signatures from purified immune cell types (with a focus on CD14 and CD4/CD8) and selected single cell level analyses. Principle data layers will comprise SNP variome, methylome, transcriptome and gut microbiome. SYSCID employs a dedicated data management infrastructure, strong algorithmic development groups (including an SME for exploitation of innovative software tools for data deconvolution) and will validate results in independent retrospective and prospective clinical cohorts.
Using this setup we will focus on three fundamental aims : (i) the identification of shared and unique ""core disease signatures” which are associated with the disease state and independent of temporal variation, (ii) the generation of ""predictive models of disease outcome""- builds on previous work that pathways/biomarkers for disease outcome are distinct from initial disease risk and may be shared across diseases to guide therapy decisions on an individual patient basis, (iii) ""reprogramming disease""- will identify and target temporally stable epigenetic alterations in macrophages and lymphocytes in epigenome editing approaches as biological validation and potential novel therapeutic tool .
Thus, SYSCID will foster the development of solid biomarkers and models as stratification in future long-term systems medicine clinical trials but also investigate new causative therapies by editing the epigenome code in specific immune cells, e.g. to alleviate macrophage polarization defects."

Koordinator 

Christian-Albrechts-Universität zu Kiel

Laufzeit 

01.01.2017 - 31.03.2022

Website

Partner

Prof. Dr. Dr. Peter Bartmann
Zentrum für Kinderheilkunde
Venusberg-Campus 1
Gebäude 30
53127 Bonn

Abstract

The project’s overall aim is to improve the health, development and quality of life of children and adults born very preterm (VPT, < 32 weeks of gestation) or very low birth weight (VLBW, < 1500g) – approximately 50 000 births each year in Europe – by establishing an ICT platform to integrate, harmonise and exploit the wealth of data from 20 European cohorts of VPT/VLBW children and adults and their families constituted from the early 1980s to the present, together with data from national registries.
VPT/VLBW births have higher risks of cerebral palsy, visual and auditory deficits, impaired cognitive ability, psychiatric disorders and social problems than infants born at term and account for more than a third of the health and educational budgets for children. They may also face higher risks of non-communicable disease as they age. There is emerging evidence of reduced mental health, quality of life, partnering, family life and employment chances and wealth in adulthood.
The platform will enable stratified sub-group analyses of sociodemographic and clinical characteristics, neonatal complications, and otherwise rare medical conditions that cannot be studied in national population cohorts. The broad temporal, geographic, cultural and health system diversity makes it possible to study the impact of socioeconomic and organisational contexts and determine the generalisability of outcomes for VPT/VLBW populations.
The RECAP platform creates a value chain to promote research and innovation using population cohorts, beginning with the integration of VPT/VLBW cohorts to the translation and dissemination of new knowledge. It will be based on a sustainable governance framework, state-of-the art data management and sharing technologies, tools to strengthen research capacity, a hypothesis-driven research agenda and broad stakeholder participation, including researchers, clinicians, educators, policy makers and very preterm children and adults and their families.

Koordinator 

Nederlandse Organisatie Voor Toegepast Natuurwetenschappelijk Onderzoek Tno

Laufzeit 

01.01.2017 - 30.09.2021

Website22

Partner 

Prof. Dr. Jan Felix Drexler
Institut für Virologie
Venusberg-Campus 1
Gebäude 63
53127 Bonn

Abstract

"ZIKAlliance is a multidisciplinary project with a global ""One Health"" approach, built: on a multi-centric network of clinical cohorts in the Caribbean, Central & South America; research sites in countries where the virus has been or is currently circulating (Africa, Asia, Polynesia) or at risk for emergence (Reunion Island); a strong network of European and Brazilian clinical & basic research institutions; and multiple interfaces with other scientific and public health programmes. ZIKAlliance will addrees three key objectives relating to (i) impact of Zika virus (ZIKV) infection during pregnancy and short & medium term effects on newborns, (ii) associated natural history of ZIKV infection in humans and their environment in the context of other circulating arboviruses and (iii) building the overall capacity for preparedness research for future epidemic threats in Latin America & the Caribbean. The project will take advantage of large standardised clinical cohorts of pregnant women and febrile patients in regions of Latin America and the Caribbean were the virus is circulating, expanding a preexisting network established by the IDAMS EU project. I will also benefit of a very strong expertise in basic and environmental sciences, with access to both field work and sophisticated technological infrastructures to characterise virus replication and physiopathology mechanisms. To meet its 3 key objectives, the scientific project has been organised in 9 work packages, with WP2/3 dedicated to clinical research (cohorts, clinical biology, epidemiology & modeling), WP3/4 to basic research (virology & antivirals, pathophysiology & animal models), WP5/6 to environmental research (animal reservoirs, vectors & vector control) , WP7/8 to social sciences & communication, and WP9 to management. The broad consortium set-up allow gathering the necessary expertise for an actual interdisciplinary approach, and operating in a range of countries with contrasting ZIKV epidemiological status."

Koordinator 

Institut National de la Sante et de la Recherche Medicale

Laufzeit 

01.10.2016 - 30.09.2021

Website 


Marie-Curie

Informieren Sie sich über die Marie-Curie-Verbundprojekte wie International Training Networks (ITN) und Research and Innovation Staff Exchange (RISE), an denen Wissenschaftler*innen der Universität Bonn beteiligt sind.

INTEGRATA_logo_w.jpg
© INTEGRATA

ITN-Projekte der Universität Bonn

Partnerin

Dr. Melanie Braun
Institute of Crop Science and Resource Conservation
Division Soil Science
Nussallee 13
D-53115 Bonn

Abstract

Plastic is a vital material in our economy and daily lives. Unfortunately, it is associated with high levels of waste and leakage to the environment. For instance, plastic debris and especially microplastics (particles less than 5 mm in size) can be found in agricultural soils – from silage bags and greenhouse cover films to sewage sludge and compost. The EU-funded SOPLAS project will assemble a multidisciplinary team to study the nexus of plastic–agriculture–soil. It will also train a new generation of leading experts. The project aims to identify the plastic cycle within agricultural soil systems and support the development of environmental policies related to mitigating the impact of plastics. The findings will advance our knowledge about the sustainable use of plastics in European agriculture.

Koordinator

Universität Augsburg

Laufzeit

01.01.2021 - 31.12.2024

Partner

Prof. Dr. Johannes Oldenburg
Institut für Experimentelle Hämatologie und Transfusionsmedizin (IHT)
Venusberg-Campus 1
53127 Bonn

Abstract

The development of anti-drug antibodies is the major complication of treatment with biotherapeutics. This is particularly true of patients with haemophilia A (HA) who develop neutralizing antibodies to therapeutic factor VIII (FVIII) following replacement therapy with exogenous pro-coagulant FVIII. The onset of neutralizing antibodies to FVIII, referred to as FVIIIinhibitors, represents a major societal concern owing to the enormous cost associated to the clinical management ofinhibitor-positive patients, that exceeds 200,000€/patient/year. The EDUC8 program is a multidisciplinary training programwith exposure of the enrolled ESRs to a core common educational package and development of individual PhD researchprojects dedicated to decreasing the societal burden associated with the development of anti-FVIII antibodies in Europe. Thecore educational program includes exposure to basic science in the fields of immunology and hemostasis, to the most advanced “omic” technologies in order to anticipate tomorrow’s scientific discoveries, and to the importance of ethical considerations and public awareness in today’s research. A key component of the training program is provided by immersion of the ESRs in a clinical center for HA, which will provide them with a unique experience and foster the conception of novel and realistic therapeutic approaches. The ESRs will exploit the accumulated theoretic and practical experience in an entrepreneurship training on key strategic, technical, financial and human resource issues required for the creation of startups. In a tribute to the concept of the fully developed mind coined by the French philosopher Michel de Montaigne on education, our ambition is to form a novel generation of scientists with deep scientific knowledge, multicultural exposure,
imagination, pragmatism and understanding of both the academic and private sectors. This will foster translational research in European on the immunogenicity of therapeutic proteins.

Koordinator

Institut National de la Sante et de la Recherche Medicale

Laufzeit

01.04.2020 - 31.03.2024

Website

Partner

Prof. Dr. Jens Lehmann
Institut für Informatik III
Endenicher Allee 19a
53115 Bonn

Abstract

With a rapidly increasing degree of integration among the European countries, a rising number of events, such as Paris shootings and Brexit, strongly impact the European community and the European digital economy across language and country borders. This development results in a vast amount of event-centric multilingual information available from different communities in the news, on the Web and in social media. Cross-lingual technologies to efficiently access, analyse and interact with this information are of utmost importance for various stakeholder groups across Europe, including digital humanities, memory institutions, publishers, media monitoring companies and journalists.

The Cleopatra ITN offers a unique interdisciplinary and intersectoral research and training programme addressing these challenges. The main objectives are to: 1) Facilitate advanced cross-lingual processing of event-centric textual and visual information on a large scale; 2) develop innovative methods for efficient and intuitive user access and interaction with multilingual information; 3) facilitate large-scale analytics of multilingual event-centric information and cross-cultural studies; 4) educate a group of top-level scientists with unique interdisciplinary and intersectoral expertise in multilingual information science who will be enabled to take leading roles in research and industry in the future; and 5) establish an interdisciplinary curriculum for cross-lingual information analytics.

The main outcomes of Cleopatra include: 1) novel methods for event-centric cross-lingual processing; 2) highly innovative user interaction paradigms for multilingual information; 3) open large-scale data sets and software components for a variety of EU languages; and 4) an interdisciplinary curriculum and educational materials. Overall, Cleopatra will contribute to the European digital economy in several application domains and strengthen the European position in multilingual information science.

Koordinator

Gottfried Wilhelm Leibniz Universität Hannover

Laufzeit

01.01.2019 - 31.12.2022

Website

Partner

Prof. Dr. Bernd Weber
Zentrum für Wirtschafts- und Neurowissenschaften
Nachtigallenweg 86
53127 Bonn

Abstract

Recent breakthroughs in neuroeconomics are helping to understand how the human decision-making process takes place. Although latest advances have revealed that most of the brain processes that regulate our emotions, attitudes and decisions are beyond our consciousness (implicit processes), many companies are still making strategic decisions relying upon explicit measures such as questionnaires and focus groups. However, the consumer neuroscience market is rapidly growing and demands new knowledge, new skills and new approaches to adapt to the technological evolution of the sector but also for comprehending and communicating with consumers. These requests only find a partial match in existing doctoral programmes.

RHUMBO addresses this challenge by delivering an innovative multinational, multi-sectorial, and multidisciplinary research and training programme in cognitive neuroscience, transparently immersive experiences and artificial intelligence with a focus on neuro-business.

From the research point of view, RHUMBO will produce tools and models to predict human decision-making in business environments. RHUMBO will use mixed reality technologies (MRT) together with different biometric signals (fMRI, fNIRS, eye tracking, EEG, etc.), supported by artificial intelligence processing techniques, to examine consumer behavioural patterns during dynamic, complex and realistic situations for a deeper understanding of internal consumer psychological states.

With this purpose, RHUMBO’s partnership aggregates relevant scientific staff from the academic and corporate worlds which will be involved in a high-level personalised training programme that will guarantee ESRs and future PhD students outstanding Career Opportunities in the consumer behaviour sector and beyond. RHUMBO will disseminate results to a wide spectrum of stakeholders, create awareness in the general public about neuroscience and encourage neuroscience vocational careers among young students.

Koordinator

Universitat Politechnica de Valencia

Laufzeit

01.11.2018 - 31.10.2022

Website 

Partner

PD Dr. Georg Feldmann
Medizinische Klinik und Poliklinik III
Sigmund-Freud-Str. 25
53127 Bonn

Abstract

Deregulated nicotinamide adenine dinucleotide (NAD) biosynthesis and signaling underlies many aspects of carcinogenesis. NAD biosynthetic enzymes, such as nicotinamide phosphoribosyltransferase (NAMPT) and nicotinic acid phosphoribosyltransferase (NAPRT), are commonly upregulated in cancer cells, where they fuel increased metabolic demands and downstream enzymes involved in DNA repair and in the promotion of cell growth, cell motility, de-differentiation and immune escape. In addition, NAD-producing enzymes, such as NAMPT, moonlight in the extracellular space, exerting strongly pro-oncogenic, autocrine and paracrine effects. Many of these roles of NAD-producing and NAD-utilizing enzymes appear to be shared between solid and haematological cancers. Thus, agents targeting NAD production or signaling are expected to have broad applicability. INTEGRATA will: 1. develop new NAD biosynthesis and NAD/nucleotide signaling inhibitors; 2. assess pharmacology and toxicity of the new therapeutics in preclinical models; 3. achieve the proof-of-concept of activity of the newly generated agents in relevant in vivo cancer models. INTEGRATA will train 14 PhD students in an overarching, interdisciplinary training programme that will include training-by-research, joint courses of technical, scientific, and transferrable skills, active participation to public scientific events, and an intense intersectoral networking exchange plan. The INTEGRATA Consortium encompasses academic institutions, research centres, and SMEs/biotech pharma, all with proven experience in higher education and training, and geared with state-of-the-art scientific and technical expertise and infrastructures.

Koordinator

Universita Degli Studi DI Genova

Laufzeit 

01.11.2018 - 31.10.2022

Website29

Partner

Prof. Dr. Seven Wehner
Klinik- und Poliklinik für Allgemein-, Viszeral-, Thorax- und Gefäßchirurgie
Venusberg-Campus 1
53127 Bonn

Abstract

The interplay between nutrition, gut microbiota, and its large numberof metabolic and immune mediators plays an essential role in the development of gut immune homeostasis in early life. This interaction needs to be better understood because a disturbed immune function in the neonatal period is harmful for neonatal survival and enhances the risk of chronic inflammatory disease later in life. In particular, preterm infants have an immature gut and an associated intestinal state of dysbiosis, which limits the efficacy of nutritional interventions to 1) support early life nutrition, 2) prevent sepsis and conditions such as necrotizing enterocolitis and intestinal failure, and 3) reduce the risk of chronic inflammatory diseases mediated by the gut. A major barrier to elucidating the critical nutritional-host-microbiome interactions and reducing neonatal mortality is the lack of expertise in this rapidly emerging area of metabolomics. We therefore proposes a multidisciplinary approach making use of a large-scale pre-existing clinical cohort of neonates, and state of the art analytical and bio-informatics tools. GROWTH is an Innovative Training Network focused on European Industrial Doctorates that aims to train young business-oriented researchers in developing pathological insights, biomarker diagnostics and personalized nutritional interventions for intestinal failure in neonates and preterm infants. As a multidisciplinary consortium that will involve the participation of 7 non-academic and 5 academic partners in the life sciences field and will attempt shortening the path from basic research to clinical applications.

Koordinator

DSCN Reseach B.V.

Laufzeit

01.06.2019 - 31.08.2023

Website

Partner

Prof. Dr. Monika Hartmann
Institut für Lebensmittel- und Ressourcenökonomik (ILR)
Nußallee 21
53115 Bonn

Abstract

Plants are intimately associated with a diversity of beneficial microorganisms in their root zone, some of which can enhance the plant’s resistance to insect pests. Thus, the use of Microbe-induced Resistance (MiR) to reduce pest losses in agriculture has emerged as a highly promising possibility to improve crop resilience and reduce use of harmful pesticides. European companies have therefore started to develop and market beneficial microbes. However, MiR appears to be strongly context-dependent, with reduced benefits under certain biotic and abiotic conditions and in some crop varieties. Further, it is a challenge to deliver and ensure stable associations of beneficial microbes and plants, and avoid undesired effects on beneficial insects. Thus we absolutely must improve our understanding of MiR mechanisms and context-dependency, in order to improve context stability of MiR and promote the use of MiR for crop protection. Our MiRA project will train 15 ESRs in basic and applied research on context-dependency of MiR, mechanisms, and impacts on plant performance and other biocontrol organisms. We will use this understanding to improve our ability to predict the effectiveness of MiR under different conditions, to select plant and microbial strains with improved context-stability, and to develop better methods for the formulation of microbial inoculants and their application in agriculture. Finally, we will analyse economic prospects and constraints for MiR development and use. To achieve these goals, we have assembled a consortium of 11 academic institutions and 6 companies, including microbial inoculant producers and agricultural advisors, with complementary skills in basic and applied research and innovation. Our ESRs will be trained within this multi-sectoral interdisciplinary network for a future career in research, product and service development in European horticulture and agriculture, pushing boundaries in European research and innovation.

Koordinator

Kobenhavns Universitet

Laufzeit

01.12.2017 - 30.11.2021

Website31

Partner

Prof. Dr. Dr. Helga Sauerwein
Institut für Tierwissenschaften
Katzenburgweg 7 - 9
53115 Bonn

Abstract

The European “Joint Doctorate in Molecular Animal Nutrition” – MANNA – includes 6 universities, 9 private companies and 3 public research institutes from 8 European countries. The goal is to:
1) develop an Elite European School to train early stage researchers (ESR) in OMIC technologies applied to animal nutrition and in essential scientific, entrepreneurial and management skills;
2) evaluate the influence of innovative feed additives on animal production;
3) deliver double doctoral (PhD) degrees in a multidisciplinary and multi-sectoral network to develop a generation of internationally equipped scientists for the global workplace.
The objectives will be achieved by co-supervising each of 11 ESRs with two Beneficiary Universities and a non-academic participant. They will work on integrated innovative research projects, designed to investigate the effects of anti-oxidants, microRNA, exosomes, methionine, lipids and plant derived anti-inflammatories in livestock diets on growth, intestinal health and systemic metabolism which will be assessed by integrating transcriptomic, microbiomic, proteomic and metabolomic approaches in both in vivo and in vitro models. The results will go into informatic platforms to build analytic systems based on IBM-Watson cognitive computing. Secondments will enhance the research programmes of all ESR being based in industry and non-academic research institutes, whose field of activity include animal nutrition, veterinary diagnostic and clinical research, bioinformatics and professional communication in the agro-food sector. All will contribute to training by including ESR in their working team, and providing lectures and training sessions in Summer Schools and workshops which will reinforce the graduate programmes of each University. The joint governance structure of MANNA will manage the recruitment, supervision and assessment processes across the network and will become embedded in the future post graduate education of each University.

Koordinator

University of Glasgow

Laufzeit

01.06.2018 - 31.05.2022

Website

RISE-Projekte der Universität Bonn

Partner

Prof. Dr. Günter Mayer
University of Bonn
Life & Medical Sciences Institute (LIMES)
Chemical Biology
Gerhard-Domagk-Straße 1
53121 Bonn

Abstract

Non-codingRNAs (ncRNAs) represent a large class of molecules that in concert regulate the expression of genes involved in the key pathways governing cancer development and progression. They represent ideal targets for personalized cancer therapies and if appropriately designed they can provide specific, non-toxic and effective therapeutic tools. The identification of novel therapeutic ncRNAs and the design of their appropriate formulation is a key aspect for their clinical applicability. RISE- cONCReTE aims to form an international and inter-sectoral network of organizations working on a joint research programme on the development of a safe ncRNA-based drug. RISE- cONCReTE teams up experts in the fields of Molecular Oncology, Epigenetics, Signal transduction, Animal models, Therapeutic delivery and Imaging, business, and education. The participants will exchange skills, knowledge and staff members that will be exposed to synergetic and complementary research environments. RISE- cONCReTE will undertake an integrated approach to reveal novels functional links between ncRNAs and oncogenic pathways. We will: a) characterize novel classes of tumor-associated ncRNAs; b) investigate the impact of ncRNAs on key aspects of tumor cell biology; c) develop cargoes (e.g. aptamers) for delivering therapeutic ncRNA derivatives into specific cancer cell types. By using innovative in vivo imaging tools, we will monitor the accumulation of target ncRNAs in cancer cells and evaluate their biological efficacy in inhibiting the growth and spreading of malignant tumors. The resulting approaches will provide stable and effective tools thus potentially improving the quality of life (QOL) of the cancer patients. Further, the joint research and training programme of RISE- cONCReTE will be performed in academic institutions and SME to provide a unique interdisciplinary platform for scientists with a significant contribution to EU competitiveness.

Laufzeit 

01.05.2020 - 30.04.2024

Website

Partnerin

Institut für Tierwissenschaften
Katzenburgweg 7 - 9
53115 Bonn

Abstract

The ability of national and international agencies to cope effectively with large-scale natural disasters is becoming more and more important. The United Nations Office for the Co-ordination of Humanitarian Affairs (OCHA, 2016) reports an increase in the frequency and impact of large-scale natural disasters in both the developed and developing world. Recent extreme events such as Storm Jonas (2016, USA), the earthquake and tsunami in Tōhoku (2011) and New Zealand (2016) have demonstrated the need for a rapid and effective external response to complex events, and the impact on the human population when this is delayed or inadequate. The Emergency Resources Supply Chain (ERSC) has a crucial role in promoting the effective application of disaster management, and differs from conventional supply chains in several ways. The unique characteristics of ERSC include: a) having to analyse all the demands in a very short period of time, using limited resources. b) having to be designed, constructed and maintained in order to support continuous and smooth materials and information flows, and c) having to include a set of diverse plans, resources, authorities, agencies, and their associated human resources.
A recent review has emphasized the relative scarcity of the literature on these topics, and research on ERSC vulnerability/ resilience is particularly underdeveloped. This project will develop a decision support framework to capture and minimize the vulnerability of ERSC in large-scale natural disasters, and increase resilience when impacted by adverse circumstances. This joint collaboration will a) explore and understand the nature of ERSC vulnerability and the root causes of failures, and b) develop and enhance a framework for identifying the vulnerable components and evaluating the performance. The research results will facilitate the analysis of the relationship between ERSC vulnerability and capacity, and therefore increase resilience to adverse circumstance.

Laufzeit

01.05.2019 - 31.01.2024


Ihre Ansprechpersonen im Forschungsdezernat

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Dr. Ulrike Pag

Dipl. Biol.

0.006

Poppelsdorfer Allee 47

53115 Bonn

+49 228 73-3073

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Dorothee Eder

Dipl. Geogr.

0.007

Poppelsdorfer Allee 47

53115 Bonn

+49 228 73-7346

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