de
Tongtong Wang
© Tongtong Wang
Prof. Dr. Tongtong Wang

Zugehörigkeiten
  • Institut für Pharmakologie und Toxikologie
Forschungsschwerpunkte
  • adipocyte metabolism
  • multi-omics
Our lab investigates adipose tissue heterogeneity under diverse physiological and pathological conditions. We focus on how this heterogeneity impacts energy expenditure, adipocyte metabolic function, and the progression of obesity. To achieve this, we employ a cutting-edge, multi-omics approach that integrates spatial transcriptomics, spatial metabolomics, and single-cell functional genomics. This powerful combination allows us to simultaneously map gene activity, metabolic profiles, and cellular functions directly within the tissue's complex microenvironment. By elucidating the fundamental mechanisms of adipose tissue, our ultimate goal is to identify novel and effective therapeutic targets to combat obesity.
Ausgewählte Publikationen

Wang T, Sharma AK, Wu C, Maushart CI, Ghosh A, Yang W, et al. Single-nucleus transcriptomics identifies separate classes of UCP1 and futile cycle adipocytes. Cell Metab. 2024 Sept 3;36(9):2130-2145.e7.

Wang T, Sharma AK, Wolfrum C. Novel insights into adipose tissue heterogeneity. Rev Endocr Metab Disord. 2022 Feb;23(1):5-12. doi: 10.1007/s11154-021-09703-8. Epub 2021 Dec 21. PMID: 34935088; PMCID: PMC8873131. [Open Access]

Wang T, Yin Q, Ma X, Tong MH, Zhou Y. Ccdc87 is critical for sperm function and male fertility. Biol Reprod. 2018 Oct 1;99(4):817-827. doi: 10.1093/biolre/ioy106. PMID: 29733332.

Liu Q, Ge W, Wang T, Lan J, Martínez-Jarquín S, Wolfrum C, Stoffel M, Zenobi R. High-Throughput Single-Cell Mass Spectrometry Reveals Abnormal Lipid Metabolism in Pancreatic Ductal Adenocarcinoma. Angew Chem Int Ed Engl. 2021 Nov 8;60(46):24534-24542. doi: 10.1002/anie.202107223. Epub 2021 Oct 11. PMID: 34505339; PMCID: PMC8597026. [Open Access] 

Tongtong Wang
© Tongtong Wang
Prof. Dr. Tongtong Wang

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