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Tanja Schneider
© UKB
Prof. Dr. Tanja Schneider

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Zugehörigkeiten
  • Institut für Pharmazeutische Mikrobiologie
Forschungsschwerpunkte
  • antibiotics
  • mode of action
  • resistance
Tanja Schneider is professor for Pharmaceutical Microbiology and focus of her research is on the bacterial cell envelope as a target for (new) antibiotics. Of particular interest is the elucidation of molecular mechanisms of action and resistance and the identification and characterization of novel antibacterial targets. Pivotal to these efforts is the discovery of novel antibiotics and to understand the biology beyond an antibiotic target as well as its integration into the cellular network of bacteria in support of drug discovery. In the course of the German Center for Infection Research a comprehensive antibiotic analysis and screening platform has been established.
Ausgewählte Publikationen

Shukla R, Peoples AJ, Ludwig KC, Maity S, Derks MGN, De Benedetti S, Krueger AM, Vermeulen BJA, Harbig T, Lavore F, Kumar R, Honorato RV, Grein F, Nieselt K, Liu Y, Bonvin AMJJ, Baldus M, Kubitscheck U, Breukink E, Achorn C, Nitti A, Schwalen CJ, Spoering AL, Ling LL, Hughes D, Lelli M, Roos WH, Lewis K, Schneider T*, Weingarth M* (2023) An antibiotic from an uncultured bacterium binds to an immutable target. Cell. S0092-8674(23)00853-X. *corresponding author

Grein F, Müller A, Scherer KM, Liu X, Ludwig KC, Klöckner A, Strach M, Sahl HG, Kubitscheck U, Schneider T (2020) Ca2+-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids. Nat Commun. 11(1):1455. doi: 10.1038/s41467-020-15257-1.

Ling LL*, Schneider T*, Peoples AJ, Spoering AL, Engels I, Conlon BP, Mueller A, Schäberle TF, Hughes DE, Epstein S, Jones M, Lazarides L, Steadman VA, Cohen DR, Felix CR, Fetterman KA, Millett WP, Nitti AG, Zullo AM, Chen C, Lewis K (2015) A new antibiotic kills pathogens without detectable resistance. Nature. 517(7535):455-9. Erratum in: Nature. 520(7547):388. *contributed equally

Schneider T, Kruse T, Wimmer R, Wiedemann I, Sass V, Pag U, Jansen A, Nielsen AK, Mygind PH, Raventós DS, Neve S, Ravn B, Bonvin AM, De Maria L, Andersen AS, Gammelgaard LK, Sahl HG, Kristensen HH (2010) Plectasin, a fungal defensin, targets the bacterial cell wall precursor Lipid II. Science. 328(5982):1168-72.

Tanja Schneider
© UKB
Prof. Dr. Tanja Schneider

Webseite

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