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Sevin Turcan
© Bernadett Yehdou
Prof. Dr. Sevin Turcan

Zugehörigkeiten
  • Center for Neurology
Forschungsschwerpunkte
  • brain tumors
  • single-cell & spatial multi-omics
  • epigenetic reprogramming
Since September 2025, I have been a W2 Professor of Experimental Neuro-Oncology at University Hospital Bonn. I earned a B.S. in Biomedical Engineering from Johns Hopkins University and a Ph.D. from Tufts University. After postdoctoral research at Memorial Sloan Kettering Cancer Center, I led a Max-Eder Junior Research Group at Heidelberg University Hospital. My lab investigates how epigenetic and transcriptional programs shape brain tumors. We integrate single-cell and spatial multi-omics with functional genomics and advanced imaging (particularly light-sheet fluorescence microscopy) to dissect tumor plasticity, microenvironmental interactions, and therapy resistance, revealing actionable vulnerabilities. Our translational work spans mechanism to intervention, studying gliomagenesis and informing biomarker-guided therapeutic strategies.
Ausgewählte Publikationen

Schwartz AV, Chao G, Robinson M, Conley BM, Ahmed Adam MA, Wells GA, Hoang A, Albekioni E, Gallo C, Weeks J, Yunker K, Quichocho G, George UZ, Niesman I, House CD, Turcan Ş*, Sohl CD* (2025). Catalytically distinct metabolic enzyme isocitrate dehydrogenase 1 mutants tune phenotype severity in tumor models. J Biol Chem. May;301(5):108477

Blanco-Carmona E, Narayanan A, Hernandez I, Nieto JC, Elosua-Bayes M, Sun X, Schmidt C, Pamir N, Özduman K, Herold-Mende C, Pagani F, Cominelli M, Taranda J, Wick W, von Deimling A, Poliani PL, Rehli M, Schlesner M, Heyn H, Turcan Ş (2023). Tumor heterogeneity and tumor-microglia interactions in IDH mutant gliomas. Cell Rep Med. Nov 21;4(11):101249.

Demirdizen E, Al-Ali R, Narayanan A, Sun X, Varga JP, Steffl B, Brom M, Krunic D, Schmidt C, Schmidt G, Bestvater F, Taranda J, Turcan Ş* (2023). TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing. Neuro Oncol. Jun 2;25(6):1031-1043. 

Turcan S#, Makarov V, Taranda J, Wang Y, El-Amine N, Haddock S, Nanjangud G, LeKaye CH, Brennan C, Cross J, Huse JT, Kelleher NL, Osten P, Thompson CB, Chan TA#. Mutant IDH1-dependent chromatin state reprogramming, reversibility, and persistence (2018). Nature Genetics 2018 Jan;50(1):62-72

Sevin Turcan
© Bernadett Yehdou
Prof. Dr. Sevin Turcan

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