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Marc Hübner
Prof. Dr. Marc Hübner

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Zugehörigkeiten
  • Institut für Med. Mikrobiologie, Immunologie und Parasitologie (IMMIP)
Forschungsschwerpunkte
  • tropical medicine
  • filariasis
The focus of my lab is the identification and preclinical testing of new therapies against parasitc helminths, which is done in close collaboration with partners from industry and non-profit organizations. Furthermore, my lab studies protective immune responses against filariae, especially the protective role of eosinophils and the contribution of extracellular DNA traps (ETosis). Finally, I am interested in the filarial immunomodulation and its beneficial impact on life-style diseases such as diet-induced insulin resistance. For our research we use the Litomosoides sigmodontis animal model and conduct studies with filariasis patients with partners in Cameroon.
Ausgewählte Publikationen

Hübner MP, Martin C, Specht S, Koschel M, Dubben B, Frohberger SJ, Ehrens A, Fendler M, Struever D, Mitre E, Vallarino-Lhermitte N, Gokool S, Lustigman S, Schneider M, Townson S, Hoerauf A, Scandale I (2020) Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro. PLoS Negl Trop Dis 14:e0008427.

Taylor MJ et al. (2019) Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis. Sci Transl Med 11.

Surendar J, Frohberger SJ, Karunakaran I, Schmitt V, Stamminger W, Neumann AL, Wilhelm C, Hoerauf A, Hübner MP (2019) Adiponectin Limits IFN-gamma and IL-17 Producing CD4 T Cells in Obesity by Restraining Cell Intrinsic Glycolysis. Front Immunol 10:2555.

Bakowski MA et al. (2019) Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections. Sci Transl Med 11.

Marc Hübner
Prof. Dr. Marc Hübner

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