Florian I. Schmidt
Prof. Dr. Florian I. Schmidt
  • Institute of Innate Immunity
  • viral infection
  • immune signaling
  • nanobodies
The Schmidt lab seeks to uncover molecular mechanisms of the inflammatory response against pathogens. To gain unique insights into protein function, we use custom-made camelid nanobodies to perturb, visualize and ultimately understand immunological signaling cascades and their effectors in the responding cell types., We employ nanobodies and other molecular tools to investigate how virus infection triggers the assembly of inflammasome complexes in various cell types, including primary cells of the immune system, the skin, and intestinal organoids. To delineate common strategies, we compare the responses to a number of DNA and RNA viruses.
Ausgewählte Publikationen

Franklin BS, Latz E, Schmidt FI (2018) The intra- and extracellular functions of ASC specks. Immunol Rev 281:74–87

Lu A, Li Y, Schmidt FI, Yin Q, Chen S, Fu T-M, Tong AB, Ploegh HL, Mao Y, Wu H (2016) Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism. Nat Struct Mol Biol 23:1–12

Schmidt FI, Hanke L, Morin B, Brewer R, Brusic V, Whelan SPJ, Ploegh HL (2016) Phenotypic lentivirus screens to identify functional single domain antibodies. Nat Microbiol Jun 20;1(8):16080.

Schmidt FI, Lu A, Chen JW, Ruan J, Tang C, Wu H, Ploegh HL (2016) A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly. J Exp Med 213:771–790

Florian I. Schmidt
Prof. Dr. Florian I. Schmidt
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