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Research - TRA Life and Health

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Research TRA Life and Health

This Transdisciplinary Research Area (TRA) promotes scientific cooperation within and between the fields of medicine, life sciences, pharmacology, nutrition research, mathematics and computer science. Construction and Deconstruction of Life is a new research program launched by the TRA in parallel to its existing Life and Health research focuses.

 

 

Construction

This research focus area concerns the construction of reductionistic systems of living matter through the usage of stem cell technologies, gene editing, nanotechnology and biomaterials as well as semi-synthetic biohybrids to derive deterministic or self-organizing models of development and disease.

The Bonn Organoid Club provides a forum for researchers active in the TRA and other interested scientists to exchange information and views regarding the development and usage application of organoids in a wide range of biological systems. 

Deconstruction

Scientists active in the TRA utilize state-of-the-art technologies to study the immune and nervous systems and other complex biological systems of subjects ranging from simple model organisms to human beings. Immunologists and neuroscientists collaborate with systems biologists and mathematicians in the ImmunoSensation2 Cluster of Excellence, which represents a primary focus within the Transdisciplinary Research Area.
Breakthroughs have been attained in understanding certain functions on the organism level through intricate study, but a general theoretical and scale-independent comprehension of these systems remains elusive. This TRA will be increasingly focusing its work on the nexus point of artificial intelligence, machine learning and life sciences, studying behavioral disease phenotypes on the basis of high-dimensional data of varying complexities.
Another key element in building predictive models of human disease is the integration of clinical, genetic, molecular, and cellular data by relying on mathematics and modeling.

 

Collaborative Research Projects

EXC 2151 - ImmunoSensation2: The Immune Sensory System

TRR 57 - Organ Fibrosis: From Mechanisms of Injury to Modulation of Disease

TRR 83 - Molecular Architecture and Cellular Functions of Lipid/Protein Assemblies

TRR 237 - Nucleid Acid Immunity

TRR 259 - Aortic Disease

TRR 261 - Cellular Mechanisms of Antibiotic Action and Production

SFB 1089 - Synaptic Micronetworks in Health and Disease

GRK 1873 - Pharmacology of 7TM-Receptors and Downstream Signalling Pathways

GRK 2168 - Myeloid antigen presenting cells and the induction of adaptive immunity

FOR 2372 - G Protein Signalling Cascades: with new modular probes and modulators towards novel pharmacological concepts

FOR 2743 - Mechanical Stress Protection

BMBF: German Center for Infection Research (DZIF)

BMBF: Diet-Body-Brain - From Epidemiology to Evidence-based Communication (Kompetenzcluster Ernährungsforschung)

BMBF: IntegraMent - Integrated Understanding of Causes and Mechanisms in Mental Disorders

BMBF: TAKeOFF - Netzwerk zur Überwindung der Schwierigkeiten bei der Bekämpfung von Filariose

EU: ENERI - European Network of Research Ethics and Research Integrity

EU: MACUSTAR - "Intermediate AMD: Development of novel clinical endpoints for clinical trials in patients with a regulatory and patient access intention"

 

Awards

5 Leibniz Prizes:
Prof. Dr. Eicke Latz (2018)
Prof. Dr. Frank Bradke (2016, on leave at DZNE)
Prof. Dr. Gunther Hartmann (2012)
Prof. Dr. Christian Kurts (2012)
Prof. Dr. Michael Famulok (2002)

1 Heinz-Maier-Leibnitz Prize
Prof. Dr. Elvira Mass (2020)

2 ERC Starting Grants:
Dr. Bernardo Franklin, Prof. Dr. Elvira Mass, Dr. Katrin Paeschke

2 ERC Consolidator Grants:
Prof. Dr. Eicke Latz, Prof. Dr. Günter Mayer

 

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