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Graduiertenkolleg GRK 677 - Veröffentlichungen unter Mitwirkung von Kollegiatinnen und Kollegiaten

Artikel in wissenschaftlichen Journalen



Swennen EL, Ummels V, Buss I, Jaehde U, Bast A, Dagnelie PC.
ATP sensitizes H460 lung carcinoma cells to cisplatin-induced apoptosis.
Chem Biol Interact. 2010 Mar 30;184(3):338-45.

Rotte A, Garmann D, Buss I, Jaehde U.
Effect of extracellular ATP on cisplatin-induced cytotoxicity in human ovarian carcinoma cells.
Chemotherapy. 2010;56(1):1-8.

Pick A, Müller H, Wiese M.
Novel lead for potent inhibitors of breast cancer resistance protein (BCRP). Bioorg. Med. Chem. Lett. 2010;20:180-183

Frizler M, Stirnberg M, Sisay MT, Gütschow M.
Development of Nitrile-Based Peptidic Inhibitors of Cysteine Cathepsins;
Curr Top Med Chem. 2010;10(3):294-322.

Briel D, Rybak A, Kronbach C, Unverferth K, González Tanarro CM, Gütschow M.
Thieno[2,3-d]pyrimidines and –[1,3]Oxazines as Glutamate Antagonists and Investigations on the Inhibitory Potency towards Human Leukocyte Elastase;
J. Heterocyclic Chem., in press.

Stumpfe D, Sisay MT, Frizler M, Vogt I, Gütschow M, Bajorath J.
Inhibitors of Cathepsin K and S Identified Using the DynaMAD Virtual Screening Algorithm.
ChemMedChem. 2010;5:61-64

Simonis D, Schlesinger M, Seelandt C, Borsig L, Bendas G.
Analysis of SM4 sulfatide as a P-selectin ligand using model membranes.
Biophys Chem. 2010 Feb 1. [Epub ahead of print]

Meis S, Hamacher A, Hongwiset D, Marzian C, Wiese M, Eckstein N, Royer HD, Communi D, Boeynaems JM, Hausmann R, Schmalzing G, Kassack MU
acid) tetrasodium salt] is the first non-nucleotide P2Y11 agonist and
stimulates release of IL-8 from human monocyte-derived dendritic cells.
J Pharmacol Exp Ther. 2010 Jan;332(1):238-47.



N. Salamon, C. Gurgui, E. Leistner, C. Drewke
Influence of antivitamins ginkgotoxin 5'-phosphate and deoxypyridoxine 5'-phosphate
on human pyridoxine 5'-phosphate oxidase.
Planta Med 2009;75:563-567

Y.S. Mineur, C. Eibl, G. Young, C. Kochevar, R.L. Papke, D. Gündisch and M.R. Picciotto
Cytisine-Based Nicotinic Partial Agonists as Novel Antidepressant Compounds
JPET 2009; 329:377-386

Antony, J., Kellershohn, K. Mohr-Andrä, M., Kebig, A., Prilla, S., Muth, M., Heller, H., Disingrini, T., Dallanoce, C., Bertoni, S., Schrobang, J., Tränkle, C., Kostenis, E.,  Christopoulos, A., Höltje, H.-D., Barocelli, E., De Amici, M., Holzgrabe, U., & Mohr, K. (2009). Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity.  FASEB J. 23:442-450.

D. Stumpfe, M. Frizler, M. T. Sisay, J. Batista, I. Vogt, M. Gütschow, J. Bajorath;
Hit Expansion through Computational Selectivity Searching;
ChemMedChem, 2009, 4, 52-54.


A. Eilfeld, C. M. González Tanarro, M. Frizler, J. Sieler, B. Schulze, M. Gütschow;
Synthesis and Elastase-Inhibiting Activity of 2-Pyridinyl-isothiazol-3(2H)-one 1,1-Dioxides;
Bioorg. Med. Chem. 2008, 16, 8127-8135.

L. Tan, H. Geppert, M. T. Sisay, M. Gütschow, J. Bajorath;
Integrating Structure- and Ligand-based Virtual Screening: Comparison of Individual, Parallel, and Fused Molecular Docking and Similarity Search Calculations on Multiple Targets;
ChemMedChem 2008, 3, 1566-1571.

Pick A, Müller H, Wiese M (2008)
Structure-activity relationships of new inhibitors of breast cancer resistance protein (ABCG2)
Bioorganic & Medicinal Chemistry 16:8224-8236

Garmann D, Warnecke A, Kalayda GV, Kratz F, Jaehde U (2008)
Cellular accumulation and cytotoxicity of macromolecular platinum complexes in cisplatin-resistant tumor cells
Journal of controlled release 131:100-106

Zakharova VM, González Tanarro CM, Gütschow M, Hennig L, Sieler J, Schulze B (2008)
Synthesis of N,N'-Linked Bisazaheterocycles with Sulfonamide Structure via Oxidation of S,N-Heteroaromatic Cations
Synthesis 1133-1141 

Wolf J, González Tanarro CM, Gütschow M, Sieler J, Schulze B (2008)
Synthesis of 4-(Isothiazol-3-yl)morpholines and 1-(Isothiazol-3- yl)piperazines, and their Inhibitory Activity towards Acetylcholinesterase
Helv. Chim. Acta 90:35-45


Jäger, D., Schmalenbach, C., Prilla, S., Schrobang, J., Kebig, A., Sennwitz, M., Heller, E., Tränkle, C., Holzgrabe, U., Höltje, H.D. & Mohr K. (2007). Allosteric small molecules unveil a role of an extracellular E2/transmembrane helix 7 junction for G protein-coupled receptor activation.
J. Biol. Chem. 282:34968-76.

Simonis D, Fritzsche J, Alban S, Bendas G (2007)
Affinity and kinetics of different heparins binding to P- and L-selectin.
Semin Thromb Hemost 33:534-539

Simonis D, Christ K, Alban S, Bendas G (2007)
Kinetic analysis of heparin and glucan sulfates binding to P-selectin and its impact on the general understanding of selectin inhibition.
Biochemistry 46:6156-64

Neumann K, Abdel-Lateff A, Wright AD, Kehraus S, Krick A, König GM (2007)
Novel Sorbicillin Derivatives with an Unprecedented Carbon Skeleton from the Sponge-Derived Fungus Trichoderma Species
Eur. J. Org. Chem., 2268-2275

Lacher SK, Mayer R, Sichardt K, Nieber K, Müller CE (2007)
Interaction of valerian extracts of different polarity with adenosine receptors: Identification of isovaltrate as an inverse agonist at A1 receptors.
Biochemical Pharmacology 73:248-258

Seibert SF, Krick A, Eguereva E, Kehraus S, König GM (2007)
Ascospiroketals A and B, Unprecedented Cycloethers from the Marine-Derived Fungus
Ascochyta salicorniae.
Org. Lett. Jan 18;9(2):239-242

Zisowsky J, Koegel S, Leyers S, Devarakonda K, Kassack MU, Osmak M, Jaehde U (2007)
Relevance of drug uptake and efflux for cisplatin sensitivity of tumor cells.
Biochemical Pharmacology 73:298-307

Kästner U, Hallmen C, Wiese M, Leistner E, Drewke C (2007)
The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba.
FEBS Journal 274:1036-1045



Disingini, T., Muth, M., Dallanoce, C., Barocelli, E., Bretoni, S., Kellershohn, K., Mohr,K., De Amici, M. & Holzgrabe, U. (2006). Design, synthesis and action of oxotremorine-related hybrid-type allosteric modulators of muscarinic acetylcholine receptors.

J. Med. Chem. 49:366-372.


Großmüller, M., Antony, J., Tränkle, C., Holzgrabe, U. & Mohr, K. (2006). Allosteric site in M2 acetylcholine receptors: evidence for a major conformational change upon binding of the orthosteric agonist instead of an antagonist.

Naunyn-SchmiedebergŽs Arch. Pharmacol. 372:267-276.

Elsinghorst PW, Gonzalez Tanarro CM, Gütschow M (2006)
Novel heterobivalent tacrine derivatives as cholinesterase inhibitors with notable selectivity towards butyrylcholinesterase.
J Med Chem 49:7540-7544

Fritzsche J, Alban S, Ludwig RJ, Rubant S, Boehncke WH, Schumacher G, Bendas G (2006)
The influence of various structural parameters of semisynthetic sulfated polysaccharides on the P-selectin inhibitory capacity.
Biochem. Pharmacol. 72: 474-485

Drabczynska A, Müller CE, Lacher SK, Schumacher B, Karolak-Wojciechowska J, Nasal A, Kawczak P, Yuzlenko O, Pekala E, Kiec-Kononowicz K (2006)
Synthesis and biological activity of tricyclic aryloimidazo-, pyrimido- and diazepinopurinediones.
Bioorg Med Chem 14: 7258-7281

Bertarelli DCG, Diekmann M, Hayallah AM, Rüsing D, Iqbal J, Preiss B, Verspohl E, Müller CE (2006)
Characterization of human and rodent native and recombinant adenosine A2B receptors by radioligand binding studies.
Purinergic Signalling, 2: 559-571

Yan L, Bertarelli DCG, Hayallah AM, Meyer H, Klotz KN, Müller CE (2006)
A new synthesis of sulfonamides by aminolysis of p-nitrophenylsulfonates yielding potent and selective adenosine A2B receptor antagonists.
J Med Chem 49: 4384-4391

König GM, Kehraus S, Seibert SF, Abdel-Lateff A, Müller D (2006)
Natural products from marine organisms and their associated microbes.
Chembiochem. 7(2):229-238. Review.

Seibert SF, Eguereva E, Krick A, Kehraus S, Voloshina E, Raabe G, Fleischhauer J, Leistner E, Wiese M, Prinz H, Alexandrov K, Janning P, Waldmann H, König GM (2006)
Polyketides from the marine-derived fungus Ascochyta salicorniae and their potential to inhibit protein phosphatases.
Org. Biomol. Chem. 4:2233-2240

Seibert SF, König GM, Voloshina E, Raabe G, Fleischhauer J (2006)
An attempt to determine the absolute configuration of two ascolactone stereoisomers with timedependent density functional theory.
Chirality 18(6):413-418

Hausmann R, Rettinger J, Gerevich Z, Meis S, Kassack MU, Illes P, Lambrecht G, Schmalzing G (2006)
The suramin analogue NF110 potently blocks P2X3 receptors: subtype selectivity is determined by location of sulfonic acid groups.
Mol. Pharmacol.2006 Mar 21: Epub ahead of print

Bulicz J, Bertarelli D, Baumert D, Fulle F, Müller CE, Heber D (2006)
Synthesis and pharmacology of pyrido(2,3-d)pyrimidinediones bearing polar substituents as adenosine receptor antagonists.
Bioorg. Med. Chem. 14:2837-2849

Massip S, Guillon J, Bertarelli D, Bosc JJ, Leger JM, Lacher S, Bontemps C, Dupont T, Müller CE, Jarry C (2006)
Synthesis and preliminary evaluation of new 1- and 3-[1-(2-hydroxy-3-phenoxypropyl)]xanthines from 2-amino-2-oxazolines as potential A1 and A2A adenosine receptor antagonists
Bioorg. Med. Chem. 14:2697-2719


Fritzsche J, Hünerbein I, Schumacher G, Alban S, Ludwig RJ, Gille J, Bendas G (2005)
In vitro investigation on the selectin binding mechanisms in tumor cell metastasis and their binding by heparin.
Int. J. Clin. Pharm. Th. 43: 570-572

Christ K, Rüttinger HH, Höpfner M, Rothe U, Bendas G (2005)
The Detection of UV-induced Membrane Damages by a Combination of Two Biosensor Techniques.
Photochemistry and Photobiology 81:1417-1423

El-Tayeb A, Griessmeier KJ, Müller CE (2005)
Synthesis and preliminary evaluation of [3H] PSB-0413, a selective antagonist radioligand for platelet P2Y(12) receptors.
Bioorg. Med. Chem. Lett.15:5450-5452

Griessmeier KJ, Müller CE (2005)
[3H]BQ-123 Binding to native endothelin ETA receptors in human astrocytoma 1321N1 cells
and screening of potential ligands.
Pharmacology 74:51-56 

Zschörnig O, Pietsch M, Süß R, Schiller J, Gütschow M (2005)
Cholesterol esterase action on human high density lipoproteins and inhibition studies: detection by MALDI-TOF MS.
J Lipid Res 46:803-811

Gütschow M, Pietsch M, Theman A, Fahrig J, Schulze B (2005)
2,4,5-Triphenyl-isothiazol-3(2H)-one 1,1-dioxides as inhibitors of human leukocyte elastase.
J Enzyme Inhib Med Chem 20:341-347

Pietsch M, Gütschow M (2005)
Synthesis of tricyclic 1,3-oxazin-4-ones and kinetic analysis of cholesterol esterase and actylcholinesterase inhibition.
J Med Chem 48:8270-8288

Ciarimboli G, Ludwig T, Lang D, Pavenstadt H, Koepsell H, Piechota HJ, Haier J, Jaehde U, Zisowsky J, Schlatter E (2005)
Cisplatin nephrotoxicity is critically mediated via the human organic cation transporter 2.
Am J Pathol 167:1477-84

Heim M, Scharifi M, Zisowsky J, Jaehde U, Voliotis D,  Seeber S and Strumberg D (2005) The Raf kinase inhibitor BAY 43-9006 reduces cellular uptake of platinum-compounds and cytotoxicity inhuman colorectal carcinoma cell lines.
Anticancer Drugs, 16: 129-136

Ullmann H, Meis S, Hongwiset D, Marzian C, Wiese M, Nickel P, Communi D, Boeynaems JM, Wolf C, Hausmann R, Schmalzing G, Kassack MU(2005)
Synthesis and structure-activity relationships of suramin-derived P2Y11 receptor antagonists with nanomolar potency.
J Med Chem 48(22):7040-7048

Horner S, Menke K, Hildebrandt C, Kassack MU, Nickel P, Ullmann H, Mahaut-Smith MP, Lambrecht G (2005)
The novel suramin analogue NF864 selectively blocks P2X1 receptors in human platelets with potency in the low nanomolar range.
Naunyn Schmiedebergs Arch Pharmacol 372(1):1-13 

Wolner I, Kassack MU, Ullmann H, Karel A, Hohenegger M (2005)
Use-dependent inhibition of the skeletal muscle ryanodine receptor by the suramin analogue NF676.
Br J Pharmacol 146(4):525-533

Hechler B, Magnenat S, Zighetti ML, Kassack MU, Ullmann H, Cazenave JP, Evans R, Cattaneo M, Gachet C (2005)
Inhibition of platelet functions and thrombosis through selective or nonselective inhibition of the platelet P2 receptors with increasing doses of NF449 [4,4',4,4'-(carbonylbis(imino-5,1,3-benzenetriylbis-(carbonylimino)))t etrakis-benzene-1,3-disulfonic acid octasodium salt]. J Pharmacol Exp Ther 314(1):232-243

Rettinger J, Braun K, Hochmann H, Kassack MU, Ullmann H, Nickel P, Schmalzing G, Lambrecht G (2004) Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analogue NF449 as a highly potent P2X1 receptor antagonist
Neuropharmacology 48(3):461-468


Zlotos DP, Gündisch D, Ferraro S, Tilotta MC, Stiefl N, Baumann K (2004) Bisquaternary caracurine V and iso-caracurine V salts as ligands for the muscle type of nicotinic acetylcholine receptors: SAR and QSAR studies
Bioorg. Med. Chem. 12:6277-6285

Gündisch D, Andrä M, Lenka M, Tilotta MC (2004) Synthesis and evaluation of phenylcarbamate derivatives as ligands for nicotinic acetylcholine receptors
Bioorg. Med. Chem. 12:4953-4962

Drabczynska A, Müller CE, Schumacher B, Hinz S, Karolak-Wojciechowska J, Michalak B, Pekala E, Kiec-Kononowicz K (2004) Tricyclic oxazolo(2,3-f)purinediones: potency as denosine receptor ligands and anticonvulsants
Bioorg. Med. Chem. 12:4895-4908

Voigtländer U, Mohr K (2004) Muscarinische Acetylcholin-Rezeptoren als Zielstruktur für Arzneimittel
Med. Mo. Pharm. 6:184-190

Brozovic A, Fritz G, Christmann M, Zisowsky J, Jaehde U, Osmak M, Kaina
B (2004) Long-term activation of SAPK/JNK, p38 kinase and fas-L
expression by cisplatin is attenuated in human carcinoma cells that
acquired drug resistance.
Int J Cancer 112: 974-985 
Garmann D, Warnecke A, Kratz F, Jaehde U (2004) Reactivity of novel
albumin-binding platinum complexes.
Int J Clin Pharmacol Ther 42:646-647 

Warnecke A, Fichtner I, Garmann D, Jaehde U, Kratz F (2004) Synthesis
and biological activity of water-soluble maleimide derivatives of the
anticancer drug Carboplatin designed as albumin-binding prodrugs.
Bioconjug Chem 15: 1349-59

Kiec-Kononowicz K, Karolak-Wojciechowska J, Michalak B, Pekala E, Schumacher B, Müller CE (2004) Imidazo(2,1-b)thiazepines: synthesis, structure and evaluation of benzodiazepine receptor binding.
Eur J Med Chem 39:205-218

Mohr M, Heller E, Ataie A, Mohr K and Holzgrabe U (2004) Development of a new type of allosteric modulator of muscarinic receptors: hybrids of the antagonist AF-DX 384 and the hexamethonio derivative W84.
J Med Chem 47:3324-3327

Seifert S, Stehl A, Tilotta MC, Gündisch D, Seitz G (2004) Novel enantiopure ferrugininoids active as nicotinic agents: Synthesis and radioligand binding studies.
Pharmazie 59:427-434

Peters L, Wright AD, Kehraus S, Gündisch D, Tilotta MC, König GM (2004) Prenylated indole alkaloids from Flustra foliacea with subtype specific binding on NAChRs
Planta Med. 70:883-886

Kassack MU, Braun K, Ganso M, Ullmann H, Nickel P, Böing B Müller G Lambrecht G (2004) Structure-activity relationships of analogues of NF449 confirm NF449 as the most potent and selective known P2X1 receptor antagonist.
Eur J Med Chem 39:345-357


Matsubayashi H, Amano T, Seki T, Andrä M, Sakai N (2003) Inhibitory effect of nicotine on rat catalepsy induced by haloperidol.
Jpn J Neuropsychopharmacol 23:342

Zisowsky J, Becker A, Weykam S, Kassack M and Jaehde U (2003) Assessment of platinum sensivity in human tumor cells.
Int J Clin Pharmacol Ther 41:612-613

Limbeck M, Gündisch D (2003) Tetrahydrofuranylmethylamines: An Efficient and Simple One-Step Synthesis and Biological Activities.
J Heterocyclic Chem 40:895-900

Drabczynska A, Schumacher B, Müller CE, Karolak-Wojciechowska J, Michalak B, Pekala E, and Kiec-Kononowicz K (2003) Impact of the Aryl Substituent Kind and Distance From Pyrimido[2,1-f]Purindiones on the Adenosine Receptor Selectivity and Antagonistic Properties.
Eur J Med Chem 38:397-402.

Fhid O, Pawlowski M, Jurczyk S, Müller CE, and Schumacher B (2003) Pyrimidin-8-on[2,1-f]Theophylline-9-Alkylcarboxylic Acids Amides As A(1) and A(2A) Adenosine Receptor Ligands.
Farmaco 58:439-444.

Gohlke H, Schwarz S, Gündisch D, Tilotta MC, Weber A, Wegge T, and Seitz G (2003) 3D QSAR Analyses-Guided Rational Design of Novel Ligands for the (Alpha4)2(Beta2)3 Nicotinic Acetylcholine Receptor.
J Med Chem 46:2031-2048.

Gütschow M, Pietsch M, Taubert K, Freysoldt THE, and Schulze B (2003) Synthesis of 2-Phenylisothiazol-3(2H)-One 1,1 Dioxides: Inhibitors of Human Leukocyte Elastase.
Z Naturforsch 58b:111-120.

Ozola V, Thorand M, Diekmann M, Qurishi R, Schumacher B, Jacobson KA, and Müller CE (2003) 2-Phenylimidazo[2,1-i]Purin-5-Ones. Structure-Activity Relationships and Characterization of Potent and Selective Inverse Agonists at Human A(3) Adenosine Receptors.
Bioorg Med Chem 11:347-356.

Schwarz S, Kämpchen T, Tilotta MC, Gündisch D, and Seitz G (2003) Synthesis and Nicotinic Binding Studies on Enantiopure Pinnamine Variants With an 8-Azabicyclo[3.2.1]Octane Moiety.
Pharmazie 58:295-299.

Seifert S, Gündisch D, Tilotta MC, and Seitz G (2003) Improved Synthesis and in Vitro Evaluation of Quinuclidin-2-Ene Based Ligands for the Nicotinic Acetylcholine Receptor.
Pharmazie 58:353-354.

Tränkle C, Weyand O, Voigtländer U, Mynett A, Lazareno S, Birdsall NJM, and Mohr K (2003) Interactions of Orthosteric and Allosteric Ligands With [3H]Dimethyl-W84 at the Common Allosteric Site of Muscarinic M2 Receptors.
Mol Pharmacol 64:180-190.

Voigtländer U, Jöhren K, Mohr M, Raasch A, Tränkle C, Buller S, Ellis J, Höltje H-D, and Mohr K (2003) Allosteric Site on Muscarinic Acetylcholine Receptors: Identification of Two Amino Acids in the Muscarinic M2 Receptor That Account Entirely for the M2/M5 Subtype Selectivities of Some Structurally Diverse Allosteric Ligands in N-Methylscopolamine-Occupied Receptors.
Mol Pharmacol 64:21-31.


Gohlke H, Gündisch D, Schwarz S, Seitz G, Tilotta MC, and Wegge T (2002) Synthesis and Nicotinic Binding Studies on Enantiopure Diazine Analogues of the Novel (2-Chloro-5-Pyridyl)-9-Azabicyclo[4.2.1]Non-2-Ene UB-165.
J Med Chem 45:1064-1072.

Gütschow M, Kuerschner L, Pietsch M, Ambrozak A, Neumann U, Gunther R, and Hofmann HJ (2002) Inhibition of Cathepsin G by 2-Amino-3,1-Benzoxazin-4-Ones: Kinetic Investigations and Docking Studies.
Arch Biochem Biophys 402:180-191.

Hayallah AM, Sandoval-Ramirez J, Reith U, Schobert U, Preiss B, Schumacher B, Daly JW, and Müller CE (2002) 1,8-Disubstituted Xanthine Derivatives: Synthesis of Potent A2B-Selective Adenosine Receptor Antagonists.
J Med Chem 45:1500-1510.

Lambrecht G, Braun K, Damer M, Ganso M, Hildebrandt C, Ullmann H, Kassack MU, and Nickel P (2002) Structure-Activity Relationships of Suramin and Pyridoxal-5'-Phosphate Derivatives As P2 Receptor Antagonists.
Curr Pharm Des 8:2371-2399.

Müller CE, Schumacher B, Brattstrom A, Abourashed EA, and Koetter U (2002) Interactions of Valerian Extracts and a Fixed Valerian-Hop Extract Combination With Adenosine Receptors.
Life Sci 71:1939-1949.

Pietsch M and Gütschow M (2002) Alternate Substrate Inhibition of Cholesterol Esterase by Thieno[2,3-d][1,3]Oxazin-4-Ones.
J Biol Chem 277:24006-24013.

Schröder C, Fisher S, Pieck AC, Müller A, Jaehde U, Kirchner H, Haverich A, and Macchiarini P (2002) Technique and Results of Hyperthermic (41 Degrees C) Isolated Lung Perfusion With High-Doses of Cisplatin for the Treatment of Surgically Relapsing or Unresectable Lung Sarcoma Metastasis.
Eur J Cardiothorac Surg 22:41-46.

Schumacher B, Scholle S, Holzl J, Khudeir N, Hess S, and Müller CE (2002) Lignans Isolated From Valerian: Identification and Characterization of a New Olivil Derivative With Partial Agonistic Activity at A(1) Adenosine Receptors.
J Nat Prod 65:1479-1485.


Braun K, Rettinger J, Ganso M, Kassack M, Hildebrandt C, Ullmann H, Nickel P, Schmalzing G, and Lambrecht G (2001) NF449: a Subnanomolar Potency Antagonist at Recombinant Rat P2X1 Receptors.
Naunyn Schmiedebergs Arch Pharmacol 364:285-290.

Kiec-Kononowicz K, Drabczynska A, Pekala E, Michalak B, Müller CE, Schumacher B, Karolak-Wojciechowska J, Duddeck H, Rockitt S, and Wartchow R (2001) New Developments in A1 and A2 Adenosine Receptor Antagonists.
Pure Appl Chem 73:1411-1420.

Kiec-Kononowicz K, Karolak-Wojciechowska J, Müller CE, Schumacher B, Pekala E, and Szymanska E (2001) Imidazo-Thiazine, -Diazinone and -Diazepinone Derivatives. Synthesis, Structure and Benzodiazepine Receptor Binding.
Eur J Med Chem 36:407-419.