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Margret Bülow
© Jan Lahitte
PD Dr. Margret Bülow

Website

Affiliations
  • Life & Medical Sciences Institute (LIMES)
Research topics
  • organelle networks
  • peroxisomes
  • metabolism
How does organelle function and interplay contribute to the cellular and systemic physiology? Research in my lab focuses on organelle networks and their impact on nutrient signalling pathways and metabolic homeostasis. By exploring novel techniques and approaches, we seek to understand how organelle networks, and the peroxisome in particular, contribute to nutrient signalling pathways. We study how peroxisomal metabolism defines the properties of cell membranes, how peroxisomal metabolites signal in the diet-microbiota-gut-brain-axis and how they influence mitochondrial activity.
Selected publications

Paradis M, Kucharowski N, Edwards Faret G, Maya Palacios SJ, Meyer C, Stümpges B, Jamitzky I, Kalinowski J, Thiele C, Bauer R, Paululat A, Sellin J, Bülow MH . The ER protein Creld regulates ER-mitochondria contact dynamics and respiratory complex 1 activity. Sci Adv. 2022 Jul 22;8(29):eabo0155.

Bülow MH, Wingen C, Senyilmaz D, Gosejacob D, Sociale M, Bauer R, Schulze H, et al. (2018) Unbalanced Lipolysis Results in Lipotoxicity and Mitochondrial Damage in Peroxisome-Deficient Pex19 Mutants. Mol Biol Cell. Feb 15;29(4):396-407.

Sellin J, Wingen C, Gosejacob D, […] Bülow MH (2018) Dietary Rescue of Lipotoxicity-Induced Mitochondrial Damage in Peroxin19 Mutants. PLoS Biol. Jun 19;16(6):e2004893.

Bülow MH, Bülow TR, Hoch M, Pankratz MJ, Jünger MA (2014) Src Tyrosine Kinase Signaling Antagonizes Nuclear Localization of FOXO and Inhibits Its Transcription Factor Activity. Scientific Reports Feb 11;4:4048.

Di Cara F, Bülow MH, Simmonds AJ, Rachubinski RA (2018) Dysfunctional peroxisomes compromise gut structure and host defense by increased cell death and Tor-dependent autophagy. Mol Biol Cell. Nov 1;29(22):2766-2783.

Margret Bülow
© Jan Lahitte
PD Dr. Margret Bülow

Website

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