Laboratory of Professor Ivar von Kügelgen
Professor of Molecular Pharmacology
University of Bonn

Research topics:
Molecular pharmacology of P2Y-like receptors – P2Y-receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides such as ATP for review see von Kügelgen 2006		Predicted secondary structure of the human platelet P2Y12-receptor This GPCR is involved in ADP-induced platelet aggregation and is the target of the platelet aggregation blockers clopidogrel and prasugrel see Algaier et al. 2008, Hoffmann et al. 2008, Hoffmann et al. 2009
P2Y-receptors controlling neuronal cells		Fura-2 microfluorimetry: Processes of differentiated PC12-cells cultured in the presence of nerve growth factor and neurotrophin-3 see Kulick and von Kügelgen 2002
Novel purinoceptors and related GPCRs		A new receptor for the nucleobase adenine: von Kügelgen I, Schiedel AC, Hoffmann et al. 2008, Mol Pharmacol 73:469-477 p2y5 is a GPCR for lysophosphatidic acid: Pasternack SM, von Kügelgen I, Aboud KA, et al. 2008, Nature Gen 40:329-334
Membrane bound receptors modulating the function of mast cells		HMC1 (Human mast cell line) cells stained with a FITC-conjugated antibody against CD117 (c-kit) see Molderings et al. 2007

Publications in Pubmed

List of Publications

Address: University of Bonn, Biomedical Research Center, Department of Pharmacology, Sigmund-Freud-Strasse 25,
D-53127 Bonn, Germany Tel.: +49 228 287 51274; Fax.: + 49 228 287 51275; k u g e l g e n @ u n i - b o n n . d e

Medizinische Fakultät/Medical Faculty - Universität Bonn/University of Bonn

Verantwortlich: Ivar v. Kügelgen, e m a i l : k u g e l g e n @ u n i - b o n n . d e . 27. Nov. 2009. ©2009