July 17, 2006:
A bug in the macro xrctdt has been corrected. The effect of this
bug was that families with missing maternal genotype and paternal genotype consisting of the allele of interest were erroneously considered to be reconstructable in some cases.
November 18, 2005:
Two bugs in the macro ILR have
been corrected. The first bug only affected the printing of the
distribution of mating type/ibd-score in part (A) of the output,
but had no effect on the value of the test statistics and/or P
values. The effect of the second bug was that recombinant
families were not detected in some cases and erroneously included
in the analysis.
March 14, 2005:
A bug in the macro HOTEL_FAM has
been corrected. The effect of this bug was that all children were
treated as affected, irrespective of the value given in the
variable aff_stat
September 8, 2004:
A bug in the macro ILR has been corrected. The effect of this bug was that the P-value
assigned to Holmans' triangle test (i.e., hypothesis "no linkage" and test "R and NI")
was slightly too small.
September 6, 2004:
The macro ILR has been modified. The new version calculates the weights
of the chi-square-bar distribution analytically. Thereby, simulation of the weights is avoided.
September 6, 2004:
HOTEL_CC and HOTEL_FAM have been added.
April 15, 2004:
ILR has been added.
August 8, 2001:
A bug in tdtpower has been corrected. The effect of this bug was
that sample sizes were not calculated in case that one or both of the relative
risks are assumed to be less than 0.5 (protective effect). Thanks
to An Goris (Leuven) for pointing my attention to this bug.
May 11, 2001:
The macro rctdt has been modified. The modification is related
to families for which (1) only a single parent is typed and the
genotype of this parent is AB; (2) only one allele
(say, C) not present in the available parent occurs in
the genotype of the sibship; and (3) all children are affected.
Such families were used by
the former version of rctdt only in case that either all
genotypes in the offspring are AC or all genotypes in the offspring
are BC. The modified version of rctdt now uses such families
even if both genotypes AC and BC occur in the offspring.
July 20, 2000:
EX_DMLB has been added.
July 20, 2000:
A bug in the macro rctdt has been corrected. The effect of this
bug was that the variable pruef_rc of the
detailed output file was undefined in case of a family with only
affected children.
The bug had no effect
on the main results of the macro.